Logimaks tablets, 30 pcs. (metoprolol, felodipine)
Special Price
$33.15
Regular Price
$39.00
In stock
SKU
newyork462359
Release form
Tablets. Buy Logimaks tablets, 30 pcs. (metoprolol, felodipine) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Tablets. Buy Logimaks tablets, 30 pcs. (metoprolol, felodipine) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Release form
Tablets.
Packing
30 pcs.
Pharmacological action
Logimax - a drug that has antiarrhythmic, antihypertensive and antianginal effects. When using Logimax, blood pressure stably and effectively decreases within 24 hours, that is, the entire interval between doses. It enhances the blood flow in the coronary system, increases the supply of blood to the ischemic zones of the myocardium without developing a decrease in blood supply to the brain areas, activates the functioning of blood circulation bypasses, and reduces peripheral vascular resistance. Also, increased blood pressure decreases during physical exertion, at rest and stress.
Contraindications
Hypersensitivity, acute myocardial infarction, unstable angina pectoris, severe sinus bradycardia, AV block II-III degree, sinus node weakness syndrome, severe peripheral circulation disorders, decompensated heart failure, cardiogenic shock.
Use during pregnancy and lactation
Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.
Special instructions
Caution should be exercised when combined with cardiac glycosides. LogimaxВ® may increase the symptoms of peripheral circulatory disorders, for example, "intermittent" lameness. Particular care is required in the following conditions: severe renal failure (CC less than 30 ml / min), aortic stenosis, impaired liver function, myocardial infarction complicated by acute heart failure, arterial hypotension, which in susceptible patients can cause myocardial ischemia, acute metabolic acidosis.
It is not recommended to start treatment with LogimaxВ® in patients who have not previously received antihypertensive therapy.
It is not recommended to prescribe the drug to patients with latent or revealed heart failure with clinical manifestations without appropriate therapy.
The use of LogimaxВ® may affect carbohydrate metabolism or mask hypoglycemia, however, with the use of LogimaxВ®, the risk of exposure to carbohydrate metabolism is lower than with non-selective beta-blockers.
In some cases, existing violations of AV conduction can be amplified, leading to AV blockade.
Patients taking LogimaxВ® should not be given intravenous BMKK type verapamil.
In patients with Prinzmetal angina, the frequency and severity of angina attacks may increase due to coronary spasm caused by stimulation of alpha-adrenergic receptors. In this regard, it is not recommended to prescribe non-selective beta-blockers in this group of patients. Selective beta1-blockers should be used with caution.
In patients with bronchial asthma or chronic obstructive pulmonary disease, concomitant therapy with beta2-adrenergic agonists is necessary. In the case when the patient begins to take LogimaxВ®, an increase in the dose of beta2-adrenergic agonists may be required.
With beta-blockers, anaphylactic shock can take a more severe form. The use of epinephrine (adrenaline) in a commonly used dose does not always lead to the expected therapeutic effect.
It is recommended that patients with pheochromocytoma be prescribed alpha-blockers in parallel with LogimaxВ®.
The combined use of drugs that induce the isoenzyme of CYP3A4 leads to a significant decrease in the concentration of felodipine in the blood plasma and insufficient therapeutic effect from taking the drug (see the section “Interaction with other drugs and other types of interaction”). The combined use of such drugs should be avoided.
The combined use of drugs that inhibit the CYP3A4 isoenzyme leads to a significant increase in the concentration of felodipine in blood plasma.
LogimaxВ® with grapefruit juice should be avoided due to a significant increase in the concentration of felodipine in blood plasma.
Avoid abrupt withdrawal of beta-blockers, especially in patients with a high risk of cardiovascular complications, due to the possible increase in symptoms of chronic heart failure and an increased risk of myocardial infarction and sudden death. If necessary, the withdrawal of the drug LogimaxВ® should be carried out gradually by reducing the dose within 1-2 weeks. In case of surgery, the anesthetist should be warned that the patient is taking LogimaxВ®.
It is not recommended to discontinue treatment with beta-blockers in patients who have surgery. In case of surgical intervention, the anesthesiologist should be warned about the received therapy with LogimaxВ®.
Cases of hyperplasia of the mucous membrane of the tongue and gums after taking felodipine in patients with severe gingivitis / periodontitis have been reported. This side effect can be avoided or reduced by showing good oral hygiene.
It is recommended that patients with pheochromocytoma be given alpha-blockers at the same time.
Effect on the ability to drive a car and work with
equipment During the treatment with LogimaxВ®, care must be taken when driving vehicles and engaging in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions (dizziness and fatigue may occur).
Composition
Active ingredients: felodipine 5 mg metoprolol succinate (as 50 mg metoprolol tartrate) 47.5 mg
Excipients: ethyl cellulose hydroxypropyl methyl cellulose hydroxypropyl cellulose lactose anhydrous polyoxyl 40 hydrogenated castor oil MCC paraffin polyethylene glycol sodium silicate aluminum dihydrate sodium silicate sodium dihydrate (E172).
Dosage and administration
Inside, in the morning, without chewing, washed down with water. The initial dose is 1 tablet. Once a day, if necessary, double the dose.
There is no need to adjust the treatment regimen in patients with impaired renal function. Usually, there is no need to adjust the treatment regimen in patients with impaired liver function, including in patients with cirrhosis of the liver. In the presence of symptoms of a serious liver dysfunction (e.g. in patients in the history of which there were operations with bypass surgery) should consider the possibility of reducing the dose of the drug.
In elderly patients, 1 tablet is usually sufficient. Once a day, if necessary - 2 times a day.
Side effects of
Decreased blood pressure headache, dizziness, peripheral edema, weakness, nausea, vomiting, dry mucous membrane of the oral cavity, constipation or diarrhea gingival hyperplasia
increased liver allergy, allergic skin allergies, edema)
AV block I stage, bradycardia thrombocytopenia paresthesia, depression, decreased ability to concentrate, drowsiness, insomnia, anxiety, decreased potency, sexual dysfunction I'm
shortness of breath, bronchospasm, rhinitis
impaired vision, dryness and / or eye irritation, conjunctivitis, tinnitus, taste impairment photosensitivity.
Rarely - tachycardia, palpitations, gangrene (in patients with severe peripheral circulatory disorders), amnesia, confusion, hallucinations.
Drug Interactions
Verapamil-type calcium channel blockers potentiate a negative foreign and chronotropic effect. Enhances the negative foreign and dromotropic effect of antiarrhythmic drugs (quinidine analogues, amiodarone), cardiodepressive - inhaled anesthetics. Increase the concentration of metoprolol in plasma cimetidine, hydralazine, alcohol, lowers rifampicin. Indomethacin and other prostaglandin synthetase inhibitors weaken the hypotensive effect.
Overdose
Symptoms: hypotension, sinus bradycardia, AV blockade, heart failure, cardiogenic shock, cardiac arrest, bronchospasm, nausea, vomiting, cyanosis. The first signs appear in 20 min - 2 h after reception.
Treatment: induction of vomiting, gastric lavage symptomatic therapy: in case of severe hypotension, bradycardia or threat of heart failure - beta1-agonist (in / in at intervals of 2-5 min or infusion) or dopamine (in / in) or atropine sulfate for the purpose of blockage of the vagus nerve dobutamine, norepinephrine, glucagon (1-10 mg). If necessary, the use of a heart rate driver. For the relief of bronchospasm - in / in the introduction of beta2-agonist.
Storage Conditions
At a temperature not exceeding 30 ° C.
Shelf life
3 years.
Pharmacy conditions
Pharmacy conditions
tablet dosage form of tablets
Possible product names
Logimax 5mg + 50mg Tab. prolong. deyst. p / pl / rev X30
Logimax 5mg / 47.5mg Tab. prolonged deyst. p / o X30 /! until 02.09 y. /
Logimaks 5mg / 47.5mg Tab. prolonged deyst. P / o X30! until 03.10. /
LOGIMAX N30 TABLE P / O
LOGIMAX N30 TABLE PROLONG P / O
AstraZeneca, Britain
Logimaks tablets, 30 pcs. (metoprolol, felodipine) florida in pharmacy online. Cheap price, instruction, side effects, dosage. Logimaks tablets, 30 pcs. - Sale. PayPal accept. Free shipping florida. Fast international shipping.
Tablets.
Packing
30 pcs.
Pharmacological action
Logimax - a drug that has antiarrhythmic, antihypertensive and antianginal effects. When using Logimax, blood pressure stably and effectively decreases within 24 hours, that is, the entire interval between doses. It enhances the blood flow in the coronary system, increases the supply of blood to the ischemic zones of the myocardium without developing a decrease in blood supply to the brain areas, activates the functioning of blood circulation bypasses, and reduces peripheral vascular resistance. Also, increased blood pressure decreases during physical exertion, at rest and stress.
Contraindications
Hypersensitivity, acute myocardial infarction, unstable angina pectoris, severe sinus bradycardia, AV block II-III degree, sinus node weakness syndrome, severe peripheral circulation disorders, decompensated heart failure, cardiogenic shock.
Use during pregnancy and lactation
Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.
Special instructions
Caution should be exercised when combined with cardiac glycosides. LogimaxВ® may increase the symptoms of peripheral circulatory disorders, for example, "intermittent" lameness. Particular care is required in the following conditions: severe renal failure (CC less than 30 ml / min), aortic stenosis, impaired liver function, myocardial infarction complicated by acute heart failure, arterial hypotension, which in susceptible patients can cause myocardial ischemia, acute metabolic acidosis.
It is not recommended to start treatment with LogimaxВ® in patients who have not previously received antihypertensive therapy.
It is not recommended to prescribe the drug to patients with latent or revealed heart failure with clinical manifestations without appropriate therapy.
The use of LogimaxВ® may affect carbohydrate metabolism or mask hypoglycemia, however, with the use of LogimaxВ®, the risk of exposure to carbohydrate metabolism is lower than with non-selective beta-blockers.
In some cases, existing violations of AV conduction can be amplified, leading to AV blockade.
Patients taking LogimaxВ® should not be given intravenous BMKK type verapamil.
In patients with Prinzmetal angina, the frequency and severity of angina attacks may increase due to coronary spasm caused by stimulation of alpha-adrenergic receptors. In this regard, it is not recommended to prescribe non-selective beta-blockers in this group of patients. Selective beta1-blockers should be used with caution.
In patients with bronchial asthma or chronic obstructive pulmonary disease, concomitant therapy with beta2-adrenergic agonists is necessary. In the case when the patient begins to take LogimaxВ®, an increase in the dose of beta2-adrenergic agonists may be required.
With beta-blockers, anaphylactic shock can take a more severe form. The use of epinephrine (adrenaline) in a commonly used dose does not always lead to the expected therapeutic effect.
It is recommended that patients with pheochromocytoma be prescribed alpha-blockers in parallel with LogimaxВ®.
The combined use of drugs that induce the isoenzyme of CYP3A4 leads to a significant decrease in the concentration of felodipine in the blood plasma and insufficient therapeutic effect from taking the drug (see the section “Interaction with other drugs and other types of interaction”). The combined use of such drugs should be avoided.
The combined use of drugs that inhibit the CYP3A4 isoenzyme leads to a significant increase in the concentration of felodipine in blood plasma.
LogimaxВ® with grapefruit juice should be avoided due to a significant increase in the concentration of felodipine in blood plasma.
Avoid abrupt withdrawal of beta-blockers, especially in patients with a high risk of cardiovascular complications, due to the possible increase in symptoms of chronic heart failure and an increased risk of myocardial infarction and sudden death. If necessary, the withdrawal of the drug LogimaxВ® should be carried out gradually by reducing the dose within 1-2 weeks. In case of surgery, the anesthetist should be warned that the patient is taking LogimaxВ®.
It is not recommended to discontinue treatment with beta-blockers in patients who have surgery. In case of surgical intervention, the anesthesiologist should be warned about the received therapy with LogimaxВ®.
Cases of hyperplasia of the mucous membrane of the tongue and gums after taking felodipine in patients with severe gingivitis / periodontitis have been reported. This side effect can be avoided or reduced by showing good oral hygiene.
It is recommended that patients with pheochromocytoma be given alpha-blockers at the same time.
Effect on the ability to drive a car and work with
equipment During the treatment with LogimaxВ®, care must be taken when driving vehicles and engaging in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions (dizziness and fatigue may occur).
Composition
Active ingredients: felodipine 5 mg metoprolol succinate (as 50 mg metoprolol tartrate) 47.5 mg
Excipients: ethyl cellulose hydroxypropyl methyl cellulose hydroxypropyl cellulose lactose anhydrous polyoxyl 40 hydrogenated castor oil MCC paraffin polyethylene glycol sodium silicate aluminum dihydrate sodium silicate sodium dihydrate (E172).
Dosage and administration
Inside, in the morning, without chewing, washed down with water. The initial dose is 1 tablet. Once a day, if necessary, double the dose.
There is no need to adjust the treatment regimen in patients with impaired renal function. Usually, there is no need to adjust the treatment regimen in patients with impaired liver function, including in patients with cirrhosis of the liver. In the presence of symptoms of a serious liver dysfunction (e.g. in patients in the history of which there were operations with bypass surgery) should consider the possibility of reducing the dose of the drug.
In elderly patients, 1 tablet is usually sufficient. Once a day, if necessary - 2 times a day.
Side effects of
Decreased blood pressure headache, dizziness, peripheral edema, weakness, nausea, vomiting, dry mucous membrane of the oral cavity, constipation or diarrhea gingival hyperplasia
increased liver allergy, allergic skin allergies, edema)
AV block I stage, bradycardia thrombocytopenia paresthesia, depression, decreased ability to concentrate, drowsiness, insomnia, anxiety, decreased potency, sexual dysfunction I'm
shortness of breath, bronchospasm, rhinitis
impaired vision, dryness and / or eye irritation, conjunctivitis, tinnitus, taste impairment photosensitivity.
Rarely - tachycardia, palpitations, gangrene (in patients with severe peripheral circulatory disorders), amnesia, confusion, hallucinations.
Drug Interactions
Verapamil-type calcium channel blockers potentiate a negative foreign and chronotropic effect. Enhances the negative foreign and dromotropic effect of antiarrhythmic drugs (quinidine analogues, amiodarone), cardiodepressive - inhaled anesthetics. Increase the concentration of metoprolol in plasma cimetidine, hydralazine, alcohol, lowers rifampicin. Indomethacin and other prostaglandin synthetase inhibitors weaken the hypotensive effect.
Overdose
Symptoms: hypotension, sinus bradycardia, AV blockade, heart failure, cardiogenic shock, cardiac arrest, bronchospasm, nausea, vomiting, cyanosis. The first signs appear in 20 min - 2 h after reception.
Treatment: induction of vomiting, gastric lavage symptomatic therapy: in case of severe hypotension, bradycardia or threat of heart failure - beta1-agonist (in / in at intervals of 2-5 min or infusion) or dopamine (in / in) or atropine sulfate for the purpose of blockage of the vagus nerve dobutamine, norepinephrine, glucagon (1-10 mg). If necessary, the use of a heart rate driver. For the relief of bronchospasm - in / in the introduction of beta2-agonist.
Storage Conditions
At a temperature not exceeding 30 ° C.
Shelf life
3 years.
Pharmacy conditions
Pharmacy conditions
tablet dosage form of tablets
Possible product names
Logimax 5mg + 50mg Tab. prolong. deyst. p / pl / rev X30
Logimax 5mg / 47.5mg Tab. prolonged deyst. p / o X30 /! until 02.09 y. /
Logimaks 5mg / 47.5mg Tab. prolonged deyst. P / o X30! until 03.10. /
LOGIMAX N30 TABLE P / O
LOGIMAX N30 TABLE PROLONG P / O
AstraZeneca, Britain
Logimaks tablets, 30 pcs. (metoprolol, felodipine) florida in pharmacy online. Cheap price, instruction, side effects, dosage. Logimaks tablets, 30 pcs. - Sale. PayPal accept. Free shipping florida. Fast international shipping.
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