Lordestine tablets is covered.pl.ob. 5 mg 10 pcs. (Desloratadine)

Release form

Tablets.



packaging 10 pcs

Pharmacological action

LORDESTINE - a blocker of histamine H1 receptors (long-acting).

Is the primary active metabolite of loratadine.

Inhibits the release of histamine and leukotriene C4 from mast cells.

Prevents development and facilitates the course of allergic reactions. It has anti-allergic, antipruritic and anti-exudative action.

Reduces the permeability of capillaries, prevents the development of tissue edema, relieves spasm of smooth muscles.

Almost no sedative effect and when taken in a dose of 7.5 mg does not affect the speed of psychomotor reactions.

In comparative studies of desloratadine and loratadine, there were no qualitative or quantitative differences in the toxicity of the two drugs in comparable doses (taking into account the concentration of desloratadine).

Indications

Seasonal allergic rhinitis, chronic idiopathic urticaria.

Contraindications

Pregnancy, lactation, children under 2 years of age, hypersensitivity to desloratadine.

Special instructions

Influence on the ability to drive vehicles and control mechanisms

No effect of Lordestine when used in recommended doses on the ability to drive vehicles and control mechanisms.

However, given that patients may experience drowsiness, caution is advised in case of side effects from the central nervous system.

Ingredients

Active ingredient:

desloratadine hemisulphate 5,788 (equivalent to 5 mg deslorat) :

MCC - 39 mg

calcium hydrogen phosphate dihydrate - 46.712 mg

pregelatinized starch - 7 mg

silicon dioxide colloidal (Aerosil) - 0.5 mg

magnesium stearate - 1 mg

Film shell: srvlpp 80 yellow hydrolyzed ny, titanium dioxide, talc, lecithin, aluminum lake dye-based quinoline yellow, xanthan gum, yellow iron oxide, dye-based aluminum varnish indigo carmine)

Dosage and Administration

Inside. Adults and adolescents aged 12 years and older, the drug Lordestine is prescribed at a dose of 5 mg (1 tablet) 1 time / day.

The drug is recommended to be taken at the same time of the day, regardless of the meal, with a small amount of water. Lordestine tablets should be swallowed whole without chewing.

In chronic renal and hepatic insufficiency, dosage adjustment is required: an initial dose of 5 mg is recommended to be taken every other day (according to pharmacokinetics).

Dosing recommendations for children with chronic renal and hepatic insufficiency are not available due to insufficient data.

Side effects

The most common side effects: fatigue (1.2%), dry mouth (8%), headache (0.6%).

Side effects from post-market research.

From the side of the central nervous system: dizziness, hallucinations, psychomotor hyperreactivity, insomnia, drowsiness.

From the cardiovascular system: tachycardia, palpitations.

From the digestive system: abdominal pain, dyspepsia (including nausea, vomiting, diarrhea), hyperbilirubinemia, increased activity of liver enzymes, hepatitis.

Allergic reactions: skin rash, itching, urticaria, angioedema, anaphylactic shock.

Other: dysmenorrhea, fatigue, myalgia.

Drug interaction

When combined with ketoconazole, erythromycin, azithromycin, fluoxetine and cimetidine, no clinically significant changes in plasma concentration of desloratadine were detected.

lordestine does not enhance the inhibitory effect of ethanol on psychomotor function.

Overdose

Drowsiness is noted with an overdose.

Treatment: gastric lavage, activated charcoal, symptomatic therapy. The drug is not excreted by hemodialysis. The effectiveness of peritoneal dialysis has not been established.

Storage Conditions

In a dry, dark place at 10 - 25 ° C.

Shelf life

2 years.

Deystvuyushtee substance

desloratadine

Conditions of release from drugstores srdlkrew without prescription43 recipe

Dosage PMA





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