Magnelis B6 forte tablets coated with captive. 100 mg + 10 mg 30 pcs. (magnesium, Pyridoxine)

film release

tablets coated with a

Packaging

In a package of 30 pieces.

Pharmacological action

Magnesium is a vital element that is necessary for the normal functioning of cells, is involved in most metabolic reactions.

In particular, it is involved in the regulation of transmission of nerve impulses and in muscle contraction. 1/3 of the amount of magnesium in the body accumulates in the bone tissue.

The body receives magnesium along with food. A lack of magnesium in the body can be observed with a violation of the diet (diet) or with an increase in the need for magnesium.

Pyridoxine (vitamin B6) is involved in many metabolic processes, contributes to the improvement of magnesium absorption from the digestive tract and its penetration into cells.

Serum magnesium is between 12 and 17 mg / L (1-1.4 mEq / L or 0.5-0. 7 mmol / L) indicates a moderate magnesium deficiency below 12 mg / L (1 mEq / L or 0.5 mmol / L) - indicates a severe magnesium deficiency.

Pharmacokinetics

Gastrointestinal absorption of magnesium salts occurs in part by a passive mechanism in which salt solubility plays a decisive role. The degree of this absorption does not exceed 50%.

It is excreted mainly by the kidneys.

Indications

Established magnesium deficiency, isolated or associated with other deficient conditions, accompanied by symptoms such as increased irritability, minor sleep disturbances, gastrointestinal cramps, palpitations, increased fatigue, muscle pain and cramping, and tingling sensations in the muscles.

If, after a month of treatment, there is no decrease in symptoms of magnesium deficiency, continued treatment is impractical.

Contraindications

- hypersensitivity to any of the components of the drug

- severe renal failure (KK <30 ml / min)

- phenylketonuria

- under 12 years of age (efficacy and safety not established)

- hereditary galactosemia galactosemia, malaria galactosemia syndrome galactose or lactase deficiency (due to the presence of lactose in the preparation)

- simultaneous administration of levodopa.

Precautions: moderate renal failure (danger of developing hypermagnesemia).

Pregnancy and lactation

Pregnancy

Clinical experience with a combination of magnesium citrate and pyridoxine hydrochloride in a sufficient number of pregnant women has not revealed any adverse effects on fetal malformations or fetotoxic effects. The drug Magnelis B6 forte, film-coated tablets can be used during pregnancy only if necessary, on the recommendation of a doctor.

Breastfeeding Period

Considering that magnesium passes into breast milk, it is recommended that you stop breast-feeding if you need to take the drug.

Composition

1 tab. active substances:

magnesium citrate 618.43 mg,

corresponding to the magnesium content (Mg2 +) 100 mg

pyridoxine hydrochloride 10 mg

Dosage and administration

Tablets should be taken whole with a glass of water.

Adults: 3-4 tablets / day, divided into 2-3 doses, with meals.

Children over the age of 12 years: 2-4 tablets / day, divided into 2-3 doses, with meals.

Typically, the duration of treatment is 1 month.

Side effects

The frequency of adverse reactions is classified according to the recommendations of the World Health Organization: very often ( 10%), often ( 1%

from the immune system: very rarely

from the gastrointestinal tract: unknown frequency (according to available data, estimate the frequency occurrence is not possible) - diarrhea, abdominal pain, nausea, vomiting, flatulence

Drug Interaction

Before prescribing other medicines, you should consult your doctor about the possibility of their simultaneous administration with Magnellis B6fort, tablets coated with a film sheath.

Contraindications combinations

With levodopa: levodopa activity is inhibited by pyridoxine (if administration of this drug is not combined with peripheral decarboxylase inhibitors of aromatic L-amino acids). Any amount of pyridoxine should be avoided unless levodopa is taken in combination with aromatic L-amino acid peripheral decarboxylase inhibitors.

Recommended combinations

Concurrent use of preparations containing phosphates or calcium salts, may impair the absorption of magnesium in the intestine.

Combinations to be taken into consideration

When administered inside tetracyclines, an interval of at least 3 hours must be observed between ingestion of tetracycline and Magnellis B6 forte, tablets coated with film, since. magnesium preparations reduce the absorption of tetracyclines.



overdose Symptoms of

In normal kidney function, an overdose of magnesium when taken orally does not usually lead to toxic reactions. However, in case of kidney failure, magnesium poisoning may develop.

Symptoms of overdose, the severity of which depends on the concentration of magnesium in the blood: reducing BP nausea, vomiting CNS depression, reducing reflexes changes on the electrocardiogram, respiratory depression, coma, cardiac arrest and respiratory paralysis anuric syndrome.

Treatment

Rehydration, forced diuresis. Renal insufficiency requires hemodialysis or peritoneal dialysis.

Storage conditions

The drug should be stored out of the reach of children at a temperature not exceeding 25 ° C.

Shelf life - 2 years.

Do not use after the expiration date printed on the package.

Expiration

2 Year

Dosage form

Dosage form

tablets

Pharmstandard-Tomsk, Russia



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