Maxikold Rino sachets, orange, 5 pc. (Paracetamol, phenylephrine, Fenyramyn, ascorbic acid)

Release form

Powder.

Packaging

. Packing 5 sachets.

Pharmacological action

Combined drug.

Paracetamol is a non-narcotic analgesic, acting on the centers of pain and thermoregulation, has an analgesic and antipyretic effect.

Pheniramine - a blocker of histamine H1 receptors, reduces rhinorrhea and lacrimation, eliminates spastic phenomena.

Phenylephrine is an adrenergic agonist with moderate vasoconstrictor action (stimulation of 1-adrenergic receptors).

Ascorbic acid is involved in the regulation of redox processes, carbohydrate metabolism, blood coagulation, tissue regeneration, in the synthesis of steroid hormones increases the body's resistance to infections, reduces vascular permeability, reduces the need for vitamins B1, B2, A, E, folic acid, pantothenic acid.

Improves the tolerance of paracetamol and lengthens its effect (associated with an extension of T1 / 2).

Indications

- fever (colds and infectious diseases)

- pain (mild to moderate severity): arthralgia, myalgia, neuralgia, migraine, toothache and headache, algodismenorea

- sinusitis, rhinorrhea, .

Contraindications

- hypersensitivity

- portal hypertension

- alcoholism

- renal failure

- pregnancy (I and III trimesters)

- lactation period

- glucose-6-glucose deficiency.

Caution: congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), childhood (up to 15 years for a dosage form intended for adults), children (up to 6 years for a children's dosage form), angle-closure glaucoma, prostatic hyperplasia.

Use during pregnancy and lactation

Contraindicated.

Special instructions

During treatment, it is necessary to refrain from the use of ethanol (the development of a hepatotoxic effect is possible).

Influence on the ability to drive vehicles and control mechanisms

During the treatment period, it is necessary to refrain from driving vehicles and engaging in other potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

Ingredients

Active ingredients:

paracetamol 325 mg,

pheniramine maleate 20 mg,

pheni-lefrin hydrochloride 10 mg,

ascorbic acid 50 mg

, sugar,

, apple lemon refined acid),

titanium dioxide,

sodium citrate dihydrate,

flavor,

dye quinoline yellow,

calcium hydrogen phosphate dihydrate (tricalcium phosphate tribasic),

ethyl cellulose.

Dosage and administration

Inside, 1 packet is dissolved in 200 ml of water, taken up to 4 times / day.

Side effects

Allergic reactions (skin rash, itching, urticaria, angioedema), nausea, epigastric pain anemia, thrombocytopenia, agranulocytosis.

Increased irritability, dizziness, increased blood pressure, impaired falling asleep.

Mydriasis, paresis of accommodation, increased intraocular pressure, dry mouth, urinary retention.

With prolonged use in large doses - hepatotoxicity, hemolytic anemia, aplastic anemia, methemoglobinemia, pancytopenia nephrotoxicity (renal colic, glucosuria, interstitial nephritis, papillary necrosis).

overdose

Symptoms (caused by paracetamol): pallor of the skin, decreased appetite, nausea, vomiting, hepatonecrosis (the severity of necrosis due to intoxication depends directly on the degree of overdose).

Toxic effect in adults is possible after ingestion of more than 10-15 g of paracetamol: increased activity of hepatic transaminases, increase of prothrombin time (12-48 h after admission) detailed clinical picture of liver damage manifests itself in 1-6 days.

Rarely, hepatic insufficiency develops rapidly and may be complicated by renal failure (tubular necrosis).

Treatment: administration of SH-group donors and precursors for glutathione-methionine synthesis 8-9 h after overdose and N-acetylcysteine ​​after 12 h concentrations of paracetamol in the blood, as well as the time elapsed after its administration.

Form of Treatment

simply entails dlya accepts Inside

Pharmstandart-Leksredstva, Russia p19ro7711 Dart-Leksredstva, Russia



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