methindole tablets retard 75 mg, 50 pcs. (indometacin indometacin)

Latin name

Metin dol retard

Packing

In a blister pack of 25 tablets. In the package 2 blisters.

Indications

rheumatic diseases,

collagenosis,

sciatica,

peripheral neuritis,

discopathy,

gout (exacerbation),

acute radicular pain syndromes.

Contraindications

hypersensitivity,

gastric ulcer and duodenal ulcer,

enteritis,

enterocolitis,

bronchial asthma,

childhood (up to 14 years).

Use during pregnancy and lactation

Contraindicated.

Composition

In 1 tablet of prolonged action contains:

Active ingredient: indomethacin 75 mg.

Excipients: microcrystalline cellulose,

potato starch,

methacrylic acid copolymer,

talc,

magnesium stearate.

Dosage and administration

Metindol retard is taken orally, without chewing, during or immediately after a meal, with plenty of water or milk.

Adults: 1 or 2 tablets per day, depending on the severity of the disease and individual sensitivity.

Do not exceed a dose of more than 150 mg per day.

Side effects of

dyspeptic disorders,

gastrointestinal bleeding,

anorexia,

relapse of gastric ulcer and duodenal ulcer,

headaches,

dizziness,

confusion,

convulsions,

hypertension,

edema.

Drug Interaction

Increases plasma concentrations of digoxin, methotrexate and lithium preparations, which may increase their toxicity.

Ethanol, colchicine, ACS and corticotropin increase the risk of gastrointestinal bleeding.

Enhances the hypoglycemic action of insulin and oral hypoglycemic drugs enhances the effect of indirect anticoagulants, antiplatelet agents, thrombolytics (alteplase, streptokinase and urokinase) - there is a risk of bleeding.

Reduces the effect of diuretics, against the background of the use of potassium-sparing diuretics increases the risk of hyperkalemia, reduces the effectiveness of uricosuric and antihypertensive drugs (including beta-blockers), enhances the side effects of glucocorticosteroids,.

Cyclosporine and gold preparations increase nephrotoxicity (apparently due to the suppression of prostaglandin synthesis in the kidneys).

Cefamandol, cefaperazone, cefotetan, valproic acid, plicamycin increase the incidence of hypoprotrombinemia and the risk of bleeding.

Antacids and cholestyramine reduce indomethacin absorption.

Increases the toxicity of zidovudine (by inhibiting metabolism) in newborns increases the risk of developing toxic effects of aminoglycosides (because it decreases renal clearance and increases blood concentration).

Concurrent administration with serotonin reuptake inhibitors increases the risk of gastrointestinal bleeding.

Myelotoxic drugs increase the manifestations of hematotoxicity of the drug.

Co-administration with paracetamol increases the risk of nephrotoxic effects.

Overdose

Symptoms: nausea, vomiting, severe headache, dizziness, memory impairment and disorientation. In more severe cases, paresthesias, numbness of the limbs and convulsions are observed.

Treatment: is the rapid removal of the drug from the body and the use of appropriate symptomatic agents. Indomethacin cannot be excreted by hemodialysis.

Storage conditions

Store in a dry, dark place at a temperature of 15-25 ° C.

Keep out of the reach of children.

Do not use after expiration date.

Expiration

5 years.

Deystvuyuschee substances

indometacin

Dosage form

Dosage form

tablets prolong.

Ai Ann Polfa Rzeszow AO, Poland



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