metoclopramide tablets 10 mg, 50 pcs. (metoclopramide)

Packing

50 pcs

Pharmacological action

Metoclopramide - an antiemetic, helps reduce nausea, hiccups stimulate gastrointestinal motility. The antiemetic effect due to blockade of dopamine D2 receptors and an increase in the threshold of the trigger zone chemoreceptors is a blocker of serotonin receptors. It is believed that metoclopramide inhibits the relaxation of smooth muscle of the stomach caused by dopamine, thereby enhancing cholinergic reactions of the smooth muscles of the gastrointestinal tract. Helps to accelerate the emptying of the stomach by preventing relaxation of the body of the stomach and increasing the activity of the antrum and upper small intestine. Reduces the reflux of contents into the esophagus by increasing the pressure of the sphincter of the esophagus at rest and increases the clearance of acid from the esophagus due to an increase in the amplitude of its peristaltic contractions.

Metoclopramide stimulates prolactin secretion and causes a transient increase in circulating aldosterone, which may be accompanied by short-term fluid retention.

Indications

vomiting, nausea, hiccups of various origins (in some cases it can be effective for vomiting caused by radiation therapy or taking cytostatics)

atony and hypotension of the stomach and intestines (in particular, postoperative)

biliary dyskinesia of the biliary tract Esophagitis

flatulence

functional pyloric stenosis.

as part of the complex treatment of exacerbations of gastric and duodenal ulcer

is used to enhance peristalsis during X-ray contrast studies of the gastrointestinal tract

as a means, facilitating duodenal sounding (to accelerate the emptying of the stomach and the movement of food through the small intestine).

Contraindications

bleeding from the gastrointestinal tract

stenosis of the pylorus

mechanical intestinal obstruction

perforation of the stomach wall or bowel

pheochromocytoma

epilepsy

glaucoma

extrapyramidal disorders

Parkinson's disease

prolaktinozavisimye tumor

vomiting during therapy or antipsychotic drugs overdose in patients

breast cancer bronchial asthma in patients with hypersensitivity to

sulfites pregnancy (I trimester), lact period

anions early childhood (for children under 2 years of age - the use of metoclopramide in the form of any dosage forms is contraindicated for children under 6 years of age, parenteral administration is contraindicated)

hypersensitivity to metoclopramide or any of the components of the drug.

Do not prescribe after gastrointestinal surgery (such as pyloroplasty or intestinal anastomosis), since vigorous muscle contractions interfere with healing.

If you are hypersensitive to metoclopramide or other components of the drug, be sure to consult your doctor before taking it.

Precautions: bronchial asthma, arterial hypertension, Parkinson's disease, renal and / or liver failure, advanced age (over 65 years), childhood (increased risk of developing dyskinetic syndrome).

Pregnancy and lactation

Contraindicated in pregnancy.

When used during lactation (breastfeeding), it should be borne in mind that metoclopramide passes into breast milk.

In experimental studies, no adverse effects of metoclopramide on the fetus were found.

Composition

1 tablet contains:

Active ingredient: metoclopramide hydrochloride 10 mg

Excipients: lactose starch corn talc purified magnesium stearate sodium starch starch glycolate silicon colloidal anhydrous.

Dosage and administration

Tablets are taken 30 minutes before a meal with a little water. Adults - 5-10 mg 3-4 times a day. The maximum single dose is 20 mg, daily - 60 mg. Children over 6 years old - 5 mg 1-3 times a day.

Side effects

From the digestive system: at the beginning of treatment, constipation is possible, diarrhea is rare - dry mouth.

From the side of the central nervous system: at the beginning of treatment, a feeling of tiredness, drowsiness, dizziness, headache, depression, akathisia are possible. Extrapyramidal symptoms may occur in children and young adults (even after a single use of metoclopramide): facial muscle spasm, hyperkinesis, spasmodic torticollis (usually go away immediately after stopping metoclopramide). With prolonged use, more often in elderly patients, the phenomena of parkinsonism, dyskinesia are possible.

From the hematopoietic system: agranulocytosis is possible at the beginning of treatment.

From the endocrine system: rarely, with prolonged use in high doses - galactorrhea, gynecomastia, menstrual irregularities.

Allergic reactions: rarely - skin rash.

ЛРкарствРнноРвзаимодРйствимbr>
При одноврРмРнном примРнРнии с антихолинРргичРскими срРдствами возможно взаимноРослаблРниРэффРктов.

При одноврРмРнном примРнРнии с нРйролРптиками (особРнно фРнотиазинового ряда и производн х бутирофРнона) пов шаРтся риск возникновРния экстрапирамидн х рРакций.

При одноврРмРнном примРнРнии усиливаРтся абсорбция ацРтилсалициловой кислот , парацРтамола, этанола.

МРтоклопрамид при в/в ввРдРнии пов шаРт скорость абсорбции диазРпама и пов шаРт Рго максимальную концРнтрацию в плазмРкрови.

При одноврРмРнном примРнРнии с мРдлРнно растворяющРйся лРкарствРнной формой дигоксина возможно умРньшРниРконцРнтрации дигоксина в с вороткРкрови на 1/3. При одноврРмРнном примРнРнии с дигоксином в жидкой лРкарствРнной формРили в видРб строрастворимой лРкарствРнной форм взаимодРйствия нРотмРчРно.

При одноврРмРнном примРнРнии с зопиклоном ускоряРтся абсорбциязопиклона с кабРрголином - возможно умРньшРниРэффРктивности кабРрголина с кРтопрофРном - умРньшаРтся биодоступность кРтопрофРна.

ВслРдствиРантагонизма в отношРнии допаминов х рРцРпторов мРтоклопрамид можРт умРньшать противопаркинсоничРскоРдРйствиРлРводоп , при этом возможно пов шРниРбиодоступности лРводоп вслРдствиРускорРния РРэвакуации из жРлудка под влияниРм мРтоклопрамида. РРзультат взаимодРйствия нРоднозначн .

При одноврРмРнном примРнРнии с мРксилРтином ускоряРтся абсорбция мРксилРтина с мРфлохином - пов шаРтся скорость абсорбции мРфлохина и Рго концРнтрация в плазмРкрови, при этом возможно умРньшРниРРго побочн х эффРктов.

При одноврРмРнном примРнРнии с морфином ускоряРтся абсорбция морфина при приРмРвнутрь и усиливаРтся Рго сРдативноРдРйствиР.

При одноврРмРнном примРнРнии с нитрофурантоином умРньшаРтся абсорбция нитрофурантоина.

При примРнРнии мРтоклопрамида нРпосрРдствРнно пРрРд ввРдРниРм пропофола или тиопРнтала можРт потрРбоваться умРньшРниРих индукционн х доз.

У пациРнтов, получающих мРтоклопрамид, усиливаются и пролонгируются эффРкт суксамРтония хлорида.

При одноврРмРнном примРнРнии с толтРродином умРньшаРтся эффРктивность мРтоклопрамида с флувоксамином - описан случай развития экстрапирамидн х нарушРний с флуоксРтином - имРРтся риск развития экстрапирамидн х нарушРний с циклоспорином - пов шаРтся абсорбция циклоспорина и увРличиваРтся Рго концРнтрация в плазмРкрови.

Overdose

Hypersomnia, disorientation and extrapyramidal disorders may be noted. As a rule, the symptomatology disappears after discontinuation of the drug for 24 hours. If necessary, treatment with cholin blockers and antiparkinsonian agents is carried out.

Storage conditions

In a dry, dark place, at a temperature not exceeding 25 ° C.

The Expiration of

is 3 years.

Active ingredient

Metoclopramide

Pharmacy terms

Prescription

dosage form

Formulation

tablets

Polarma, Poland



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