Metrogyl gel vaginal 10 mg / g, 30 g (metronidazole)

Release form

vaginal gel is uniform, colorless to pale yellow.

Packing

30 g - aluminum tubes (1) complete with an applicator - packs of cardboard.

Pharmacological action

Metrogil has an antibacterial, antiprotozoal (trichomonacid) effect.

The nitro group of metronidazole is restored in anaerobic microorganisms and protozoa, interacts with the DNA of microorganism cells, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria.

Metronidazole is active against Trichomonas vaginalis, Gardnerella vaginalis, Giardia intestinalis, Entamoeba histolytica, Lamblia, anaerobic bacteria: Bacteroides spp., Fusobacterium spp.

In combination with amoxicillin, it is active against Helicobacter pylori (amoxicillin inhibits the development of resistance to metronidazole).

Aerobic microorganisms and facultative anaerobes are insensitive to metronidazole, but in the presence of mixed flora (aerobes and anaerobes), metronidazole acts synergistically with antibiotics effective against conventional aerobes.

Increases the sensitivity of tumors to radiation, causes disulfiram-like reactions, stimulates reparative processes.

When applied topically, it has an anti-acne effect whose mechanism is not exactly known.

Indications

bacterial vaginosis of various etiologies, urogenital trichomoniasis confirmed by clinical and microbiological data of

.

Contraindications

leukopenia (including history)

impaired coordination of movements

organic CNS lesions (including epilepsy)

liver failure

pregnancy - I trimester

hypersensitivity (including to nitroimidazole derivatives).

Use during pregnancy and lactation

It is possible to use the drug in the II and III trimesters of pregnancy. When prescribing the drug during lactation, it is recommended to stop breastfeeding.

Composition

1 g

metronidazole 10 mg

Excipients: propylhydroxybenzoate, propylene glycol, carbomer-940, disodium edetate, sodium hydroxide, purified water.

Dosage and administration

Intravaginally, once 2 g or as a course of treatment at 500 mg / day 2 times a day (morning and evening) for 10 days. During the course of treatment, sexual intercourse should be avoided.

Side effects

Local reactions: burning sensation or frequent urination, vulvitis in the sexual partner - burning sensation or irritation of the penis. After discontinuation of the drug, the development of vaginal candidiasis.

Systemic effects may develop: dizziness, headache, dry mouth, change in taste, including metallic taste, nausea, vomiting, decreased appetite, spastic pain in the abdominal cavity, constipation or diarrhea, dark urine staining, leukopenia or leukocytosis.

Allergic reactions: skin rash, urticaria.

If any unwanted side effects occur, discontinue treatment and consult a doctor.

Drug Interaction

Similar to disulfiram causes ethanol intolerance.

Increases the effect of indirect aitnocoagulants, it is not recommended to combine with non-depolarizing muscle relaxants (vecuronium).

Concomitant administration of lithium may increase the concentration of lithium in blood plasma.

Phenobarbital accelerates metronidazole metabolism by induction of microsomal liver enzymes, cimetidine decreases.

Overdose

No overdose of the drug was prescribed at the recommended doses.

Storage conditions

Store at a temperature not exceeding 25 ° C in places inaccessible to children.

Expiration

2 years. Do not use after the expiry date stated on the packaging.

Deystvuyuschee substances

metronidazole

dosage form

dosage form

gel vaginal

Unique Pharmaceutical, India



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