metronidazole tablets 250 mg 40 pcs. (metronidazole)

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Latin name

Metronidazole Buy metronidazole tablets 250 mg 40 pcs. (metronidazole) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Latin name

Metronidazole

Release form

Tablets are white or white with a yellowish greenish tinge of color, flat cylindrical, with bevel and chamfer.

Packing

10 pcs. in blister strip packaging, 4 packs in a cardboard bundle.

Pharmacological action of

Metronidazole belongs to 5-nitroimidazoles and has a wide spectrum of activity against anaerobic microorganisms Peptostreptococcus species, Clostridium spp., Bacterioides spp., Prevevellaella, Prevellaella pella, Prevellaella pella, Prevellaella, Prevellaella, Prevellaella, pella bellaella . Suppresses the development of protozoa - Trichomonas vaginalis, Giardia intestinalis (Lamblia intestinalis), Entamoeba histolytica. The mechanism of action is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole interacts with the deoxyribonucleic acid of cells, inhibiting the synthesis of their nucleic acids, which leads to the death of microorganisms.

Indications of

protozoal infections (extraintestinal amebiasis / including liver abscess /, intestinal amebiasis, trichomoniasis, balantidiasis, giardiasis (giardiasis), cutaneous leishmaniasis, trichomonas vaginitis, trichomonas sulcus infection, trichomonas sarditis, .h. Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus (infections of bones and joints, CNS infections / including meningitis, brain abscess /, bacterial endocarditis, pneumonia, empyema and lung abscess)

infections caused by Bacteroides spp. (including Bacteroides fragilis), Clostridium spp., Peptococcus spp., Peptostreptococcus spp. (abdominal infections / peritonitis, liver abscess /, pelvic infections / endometritis, endomyometritis, abscess of the fallopian tubes and ovaries, vaginal vaginal infections after surgery /, skin and soft tissue infections)

sepsis caused by Bacteroides spp. (including Bacteroides fragilis) and Clostridium spp.

pseudomembranous colitis (associated with the use of antibiotics)

gastritis or duodenal ulcer, associated with Helicobacter pylori

alcoholism

as a radiosensitizing agent in radiation therapy (in cases when the resistance of the tumor is due to hypoxia in the tumor cells)

prevention of postoperative infections (especially after operations on the colon, periorectal region, appendectomy, g).

Contraindications

leukopenia (including a history)

hypersensitivity to the components of the drug

impaired coordination of movements,

organic damage to the central nervous system (including epilepsy)

liver failure (if prescribed in high doses)

I trimester of pregnancy

lactation period

hypersensitivity to nitroimidazole derivatives.

Use with caution in the second and third trimesters of pregnancy.

Use during pregnancy and lactation

Contraindicated in the first trimester of pregnancy, during lactation.

Precautions: pregnancy (II-III trimesters).

Composition

Composition per tablet:

active substance: metronidazole - 250 mg

excipients: potato starch - 45.0 mg, povidone (low molecular weight polyvinylpyrrolidone medical) - 2.0 mg, stearic acid - 3.0 mg.

Dosage and administration of

In case of amoebiasis, metronidazole is administered orally to adults for 7 days, 1.5 g per day in 3 doses of

for children of 30-40 mg / kg per day, also in 3 doses of

. For giardiasis, the drug is prescribed for 5 days - adults 750-1000 mg per day, children 2-5 years old 250 mg per day, children 5-10 years old - 375 mg per day, children 10-15 years old - 500 mg per day. Take after meals 2-3 times a day.

With trichomoniasis in women (urethritis and vaginitis), metronidazole is prescribed once at a dose of 2 g or as a course of treatment for 10 days: 1 tablet (250 mg) 2 times a day. In parallel with oral administration, 1 vaginal suppository or vaginal tablet containing 250 mg of metronidazole is prescribed in the evening.

To exclude possible reinfection, it is necessary to conduct treatment at the same time as sexual partners.

The course of treatment is repeated if necessary after 4-6 weeks.

With trichomoniasis in men (urethritis), metronidazole is prescribed once at a dose of 2 g or as a course of treatment for 10 days, 1 tablet (250 mg) 2 times a day.

For nonspecific vaginitis, 500 mg of metronidazole is used 2 times a day for 7 days.

In the treatment of anaerobic infections, adults are prescribed Metronidazole 1-1.5 g per day,

for children - at the rate of 20-30 mg / kg per day.

Side effects

Allergic reactions: urticaria, skin rash.

Local reactions: burning sensation or irritation of the penis in the sexual partner, burning sensation or frequent urination, vulvitis (itching, burning pain or hyperemia of the mucous membrane in the external genital area). After discontinuation of the drug, vaginal candidiasis may develop.

Systemic reactions: possible changes in taste, including a metallic taste, dizziness, headache, dry mouth, nausea, vomiting, decreased appetite, spastic pains in the abdominal cavity, constipation or diarrhea, dark urine staining, leukopenia or leukocytosis.

ЛРкарствРнноРвзаимодРйствимbr>
При одноврРмРнном примРнРнии с антацидами, содРржащими алюминия гидроксид, с колРстирамином нРмного умРньшаРтся абсорбция мРтронидазола из ЖКТ.

При одноврРмРнном примРнРнии мРтронидазол потРнцируРт дРйствиРнРпрям х антикоагулянтов.

При одноврРмРнном примРнРнии с дисульфирамом возможно развитиРостр х психозов и нарушРниРсознания.

НРльзя исключить пов шРниРконцРнтрации карбамазРпина в плазмРкрови и пов шРниРриска развития токсичРского дРйствия при одноврРмРнном примРнРнии с мРтронидазолом.

При одноврРмРнном примРнРнии с лансопразолом возможн глоссит, стоматит и/или появлРниРтРмной окраски яз ка с лития карбонатом - возможно пов шРниРконцРнтрации лития в плазмРкрови и развитиРсимптомов интоксикации с прРднизоном - пов шаРтся в вРдРниРмРтронидазола из организма вслРдствиРускорРния Рго мРтаболизма в пРчРни под влияниРм прРднизона. Возможно умРньшРниРэффРктивности мРтронидазола.

При одноврРмРнном примРнРнии с рифампицином пов шаРтся клирРнс мРтронидазола из организма с фРнитоином - возможно нРбольшоРпов шРниРконцРнтрации фРнитоина в плазмРкрови, описан случай развития токсичРского дРйствия.

При одноврРмРнном примРнРнии с фРнобарбиталом сущРствРнно пов шаРтся в вРдРниРмРтронидазола из организма, по-видимому, вслРдствиРускорРния Рго мРтаболизма в пРчРни под влияниРм фРнобарбитала. Возможно умРньшРниРэффРктивности мРтронидазола.

При одноврРмРнном примРнРнии с фторурацилом усиливаРтся токсичРскоРдРйствиР, но нРэффРктивность фторурацила.

Описан случай развития острой дистонии послРприРма однократной доз хлорохина у пациРнта, получающРго мРтронидазол.

При одноврРмРнном примРнРнии с цимРтидином возможно ингибированиРмРтаболизма мРтронидазола в пРчРни, что можРт привРсти к замРдлРнию Рго в вРдРния и пов шРнию концРнтрации в плазмРкрови.

При одноврРмРнном примРнРнии этанола у пациРнтов, получающих мРтронидазол, возможно развитиРдисульфирамоподобн х рРакций.

Overdose

Symptoms: nausea, vomiting, ataxia when taken as a radiosensitizing agent - convulsions, peripheral neuropathy.

Treatment: No specific antidote, symptomatic and supportive therapy.

Storage conditions

In a dark place at room temperature, do not freeze.

Keep out of the reach of children.

Expiration

3 years.

Do not use after the expiry date stated on the package.

Deystvuyuschee substances

metronidazole

dosage form

dosage form

tablets

Pharmstandard-Leksredstva, Russia



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