Minaker tablets 250 mg, 21 pcs. (famciclovir)

Release form

Film-coated tablets.



packaging 21 pcs

Pharmacological action

Minaker - antiviral. The prodrug is a 6-deoxydiacetyl analogue of the active antiviral substance penciclovir. Transforming in the body into the active compound - penciclovir, acts on Herpes simplex viruses (types 1 and 2), Varicella zoster, Epstein-Barr virus.

Penetrating into virus-infected cells, penciclovir is phosphorylated by viral thymidine kinase to penciclovir monophosphate, which is then converted by action of cell kinases to penciclovir triphosphate. Penciclovir triphosphate is retained in an infected cell for more than 12 hours and inhibits viral DNA replication.

Has no effect on uninfected cells. It is active against some acyclovir-resistant strains of the Herpes simplex virus with altered DNA polymerase.

Pharmacokinetics

After oral administration, it is rapidly and almost completely absorbed and rapidly turns into active penciclovir. Bioavailability is 77%. TCmax - 45 min, Cmax after taking a single dose of 500 mg - 3.3-4.2 μg / ml. Distribution volume - 1 l / kg. Communication with plasma proteins - 20%.

T1 / 2 - 2.1-3 hours. T1 / 2 of penciclovir triphosphate from cells infected with herpes simplex virus type 1 - 10 hours, from cells infected with herpes simplex virus type 2 - 20 hours, from cells infected with varicella zoster virus - 7 h. T1 / 2 with CC less than 30 ml / min - 10-13 h.

Excreted by the kidneys by glomerular filtration and tubular secretion with urine (60-65% in the form of penciclovir), 27% with feces. Does not cumulate. It is excreted during hemodialysis.

Indications

Herpes zoster

postherpetic neuralgia

recurrent genital herpes.

Contraindications

Hypersensitivity, pregnancy, lactation, childhood.

Precautions: renal failure.

Use during pregnancy and lactation

FDA category of effect on the fetus is B.

Composition

1 tablet contains:

Active ingredient: 250 mg.

Dosage and administration of

Inside, for adults with acute herpetic infection - 250 mg 3 times a day for 7 days.

With herpes zoster (Varicella zoster) and high risk of developing postherpetic neuralgia - 250 mg 3 times a day for 7 days. Treatment should begin immediately after diagnosis.

For genital herpes caused by Herpes simplex (type II): for primary infection - 250 mg 3 times a day for 5 days, for relapses of chronic infection - 1000 mg 2 times a day once or 125 mg 2 times a day for 5 days. Treatment should begin immediately after the onset of the first symptoms of the disease.

For prevention - 250 mg 2 times a day. Periodic discontinuation of the drug at intervals of 6-12 months is recommended to assess possible changes in the course of the disease.

In patients with impaired renal excretory function, dose adjustment is required: with KK 30-59 ml / min - 250 mg 2 times a day

with KK less than 30 ml / min - 125 mg 3 times a day.

For patients on hemodialysis, 250 mg (for patients with Varicella zoster) and 125 mg (for patients with genital herpes), the dose should be taken immediately after the procedure, because after 4 hours of hemodialysis, the concentration of penciclovir in the plasma is reduced by approximately 75%.

Side effects of

Headache, nausea, dizziness, vomiting, diarrhea, allergic reactions of

in the elderly - confusion, hallucinations of

with reduced immunity - abdominal pain, fever and rarely - granulocytopenia and thrombocytopenia.

Drug interaction

drugs blocking tubular secretion, increase the plasma concentration.

Overdose

Symptoms: Failure to follow dose reduction guidelines with kidney function - Acute renal failure.

Treatment: symptomatic, hemodialysis.

Storage conditions

In a dry place, at a temperature not exceeding 30 ° C.

Expiration

3 years.



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dosage form

dosage form

tablets

Apothex Inc., Canada



Minaker tablets 250 mg, 21 pcs. (famciclovir) newyork in pharmacy online. Cheap price, instruction, side effects, dosage. Minaker tablets 250 mg, 21 pcs. - Sale. PayPal accept. Free shipping newyork. Fast international shipping.