Mucosate ampoules 100 mg / ml 2 ml, 5 pcs. (chondroitin sulfate)

Release form

Intramuscular solution.

Packing

5 ampoules.

Pharmacological action

Mucosate has chondroprotective, chondrostimulating regenerative stimulating effect.

Chondroitin sodium sulfate is an acidic mucopolysaccharide from cartilage of trachea in cattle with an average molecular weight of 11,000 Daltons (11 kiloDaltons), a stimulator of repair of connective (including cartilage) tissue.

The drug has a chondroprotective, stimulating the regeneration of cartilage tissue, anti-inflammatory effect. It participates in the construction of the main substance of cartilage and bone tissue, improves phosphorus-calcium metabolism in cartilage, inhibits enzymes that disrupt the structure and function of articular cartilage, and inhibits the degeneration of cartilage. It stimulates the synthesis of proteoglycans, normalizes the metabolism of hyaline cartilage, and promotes the regeneration of cartilage surfaces and the articular bag. Prevents compression of connective tissue, increases the production of synovial fluid and mobility of the affected joints, reduces concomitant inflammation, soreness, helps reduce the need for NSAIDs. With degenerative changes in the cartilage tissue is a means of replacement therapy.

A positive effect is observed already 2-3 weeks after the start of the drug. The therapeutic effect persists for a long time (3-6 months) after the end of the course of treatment.

Pharmacokinetics

Chondroitin sodium sulfate is readily absorbed after i / m administration. After 30 minutes, it is detected in blood in significant concentrations. Cmax is reached after 1 h, then its content gradually decreases over 2 days.

Chondroitin sodium sulfate accumulates mainly in cartilage. The synovial membrane is not an obstacle to its penetration into the joint cavity. 15 minutes after the intramuscular injection of chondroitin, sodium sulfate is found in the synovial fluid, then it enters the articular cartilage, where its content reaches a maximum after 48 hours.

Indications

Degenerative degenerative diseases of the joints and spine: primary arthrosis, intervertebral osteochondrosis, osteoarthritis, osteoporosis, periodontopathy, bone fractures (to accelerate the formation of bone marrow).

Contraindications

Hypersensitivity, tendency to bleeding, thrombophlebitis.

Composition

Active ingredient: chondroitin sodium sulfate 100 mg

Excipients: benzyl alcohol - 9 mg, water d / i - up to 1 ml.

Dosage and administration

The drug Mucosate is administered in oil 1 ml every other day. With good tolerance, the dose is increased to 2 ml, starting with the fourth injection. The course of treatment is 25-30 injections. If necessary, repeated courses are possible after 6 months.

Side effects

Allergic reactions (pruritus, erythema, urticaria, dermatitis), hemorrhages at the injection site rarely - nausea, vomiting.

Drug Interactions

Mucosat should be prescribed with caution along with direct-acting anticoagulants. It is also possible to increase the effect of indirect anticoagulants, antiplatelet agents and fibrinolytics.

Storage conditions

In a dark place at a temperature of 0–20 ° C.

Expiration

3 years

Active ingredient

Chondroitin sulfate

dosage form

rast Op

Synthesis, Russian



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