Nazik Spray 0.1 + 5 mg / dose, 10 ml (xylometazoline, Dexpanthenol)

Release form

Dosage nasal spray

Packaging

1 vial of 10 ml complete with dosing device.

Pharmacological action

Nasik is a combined topical nasal preparation containing xylometazoline and dexpanthenol.

Xylometazoline belongs to the group of local vasoconstrictors (decongestants) with alpha-adrenomimetic activity, causes narrowing of the blood vessels of the nasal mucosa, restores patency of the nasal passages, and facilitates nasal breathing. The action of the drug usually occurs within a few minutes after its use and lasts up to 10 hours.

Dexpanthenol - a vitamin of group B - a derivative of pantothenic acid. Dexpanthenol in the body turns into pantothenic acid, which is an integral part of coenzyme A and is involved in the processes of acetylation, carbohydrate and

fat metabolism, in the synthesis of acetylcholine, corticosteroids, porphyrins stimulates the regeneration of the skin, mucous membranes of

, normalizes cell metabolism and increases cell metabolism fibers. It has a regenerative, metabolic and weak anti-inflammatory effect.

PHARMACOKINETICS

Xylometazoline, when applied topically, is practically not absorbed, plasma concentrations are so small that their

cannot be determined by modern analytical methods.

Dexpanthenol, when applied topically, is rapidly absorbed by the skin and converted to pantothenic acid, binds to plasma proteins (mainly with beta-globulin and albumin). Its concentration in the blood is 0.5-1 mg / l,

in the blood serum is 100 μg / l. Pantothenic acid is not metabolized in the body (except for inclusion in Co-A), it is excreted unchanged.

Indications

For adults and children over 6 years of age.

acute respiratory infections with rhinitis

acute allergic rhinitis

vasomotor rhinitis

sinusitis

otitis media (as part of combination therapy to reduce swelling of the nasopharynx)

to facilitate rhinoscopy of the nose after surgery to restore the nasal cavity surgery to restore the nasal cavity to restore the disturbed nasal cavity.



Contraindications hypersensitivity to the drug

hypertension

tachycardia

pronounced atherosclerosis

atrophic rhinitis

hyperthyroidism

porphyria

prostatic hyperplasia

glaucoma

surgical intervention in the meninges (history)

child up to six years

simultaneous inhibitor therapy monoamine oxidases (MAOs) and tricyclic antidepressants.

Precautions: diabetes mellitus, pheochromocytoma.

Use during pregnancy and lactation

Given that there is no data on reproductive toxicity of the drug, during pregnancy and lactation, its use is not recommended.

Special instructions

Clean the nasal passages before use.

Do not use for more than 5 days.

During the period of use of the drug, precautions should be observed, or avoid driving vehicles and engaging in other potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

Composition of

1 dose contains:

Active ingredients: xylometazoline hydrochloride 0.1 mg, dexpanthenol 5 mg

Excipients: benzalkonium chloride (as a 50% solution) 0.04 mg, potassium dihydrogen phosphate 0.853 mg, sodium hydrogen phosphate dodod27 , purified water 93.98 mg.

Dosage and administration of

nasik is administered intranasally.

Remove the pump dispenser from its packaging. Uncork the vial with the drug, screw the dispensing device onto the neck of the vial, remove the protective cap.

Before using the spray for the first time, press the pump-operated metering device several times until uniform spraying appears.

When using the nasal spray, the vial must be kept upright. During injection, you need to easily inhale your nose. One injection in each nasal passage 3-4 times a day. The duration of therapy is 3-5 days.

Side effects

With frequent and / or prolonged use - irritation and / or dryness of the nasopharyngeal mucosa, burning, tingling, sneezing, hypersecretion, allergic reactions, swelling of the nasal mucosa, vomiting, headache, dry rhinitis, palpitations, increased heart rate blood pressure, insomnia, visual impairment, depression (with prolonged use of high doses).

Drug Interactions

With the simultaneous use of MAO inhibitors and tricyclic antidepressants, an increase in systemic action is possible.

Overdose

Symptoms: mydriasis, nausea, vomiting, cyanosis, fever, convulsions, heart rhythm disorder, cardiac arrest, hypertension, pulmonary edema, respiratory failure, hallucinations. Patients may also experience symptoms of CNS depression, accompanied by drowsiness, decreased body temperature, bradycardia, shock, respiratory arrest and coma.

Treatment. Activated carbon application, gastric lavage, oxygen ventilation. To reduce blood pressure, 5 mg of phentolamine is administered in 0.9% sodium chloride solution by slow intravenous administration or 100 mg of phentolamine orally. Vascular drugs are contraindicated. If necessary, use antipyretic and anticonvulsants.

Storage conditions

Keep out of the reach and sight of children, at temperatures not exceeding 25 ° C.

Shelf life

3 years. After opening, 12 weeks.

Deystvuyushtee substance

Xylometazoline, Dexpanthenol

Terms and conditions

without prescription

dosage form

nasal spray

Appointment

Appointment

vasoconstrictive



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