Nolicin tablets 400 mg, 20 pcs. (norfloxacin)

Release form

Film-coated tablets.

Packaging

20 pcs.

Pharmacological action

An antibacterial agent from the group of fluoroquinolones. It has a bactericidal effect. It acts on the bacterial enzyme DNA gyrase, which ensures supercoiling and, thus, the stability of bacterial DNA. Destabilization of the DNA chain leads to the death of bacteria. It has a wide spectrum of antibacterial action. Sensitive: Staphylococcus aureus (including methicillin-resistant strains of Staphylococcus spp.), Staphylococcus epidermidis, Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Citrobacter spp., Klebsiella spp., Enterobacter spp., Hob. (indole positive and indole negative), Salmonella spp., Shigella spp., Yersinia enterocolitica, Campylobacter jejuni, Aeromonas spp., Plesiomonas spp., Vibrio cholerae, Vibrio parahaemolyticus, Haemophilus influenzae spplam. Different sensitivity to the drug have: Enterococcus faecalis, Streptococcus spp. (pyogenes, pneumoniae and viridans), Serratia marcescens, Pseudomonas aeruginosa, Acinetobacter spp., Mycoplasma hominis, Mycoplasma pneumoniae, Mycobacterium tuberculosis, Mycobacterium fortuitum.

Indications

Infectious and inflammatory diseases caused by pathogens sensitive to the drug: acute and chronic infectious diseases of the urinary tract (urethritis, cystitis, pyelonephritis)

genital infections: cervicitis, endometritis, chronic bacterial prostatitis

gonorrhea uncomplicated

bacterial gastroenteritis (salmonellosis, shigellosis)

prevention of relapse of urinary tract infections

prevention of sepsis in patients with neutropenia

prevention of diarrhea of ​​travelers.

Contraindications

hypersensitivity to norfloxacin, drug components and other quinolones

glucose-6-phosphate dehydrogenase deficiency

childhood and adolescence (up to 18 years)

pregnancy and lactation of the brain, mild cervical dysfunction , epileptic syndrome, renal / liver failure, the presence of an allergic reaction to acetylsalicylic acid.

Pregnancy and lactation

The safety of use during pregnancy and lactation has not been studied. To prescribe the drug during pregnancy is only for "vital" indications, when the expected benefit to the mother outweighs the potential risk to the fetus. If necessary, the appointment of the drug during lactation should stop breastfeeding.

Composition

1 film-coated tablet contains:

CORE:

Active ingredient: norfloxacin - 400 mg.

Excipients: povidone, sodium carboxymethyl starch, microcrystalline cellulose, colloidal silicon dioxide, anhydrous, magnesium stearate, purified water (for hydration).

SHELL:

hapromellose, talc, titanium dioxide, dye sunny sunset yellow, Е110 (disperse yellow dye, Е110), propylene glycol.

Dosage and administration

Inside an empty stomach (at least 1 hour before or 2 hours after eating) and drink plenty of fluids.

Unless specifically prescribed by a doctor, the following doses are recommended: 1 tablet (400 mg) 2 times a day. The duration of treatment is from 7 to 14 days, if necessary, a longer treatment is carried out.

In chronic bacterial prostatitis, 400 mg is prescribed 2 times a day for 4-6 weeks or more.

In uncomplicated gonorrhea, the drug is prescribed once at a dose of 800 - 1200 mg or 2 times a day, 400 mg for 3-7 days.

With bacterial gastroenteritis (shigellosis, salmonellosis), 400 mg is recommended 2 times a day for up to 5 days.

To prevent diarrhea of ​​travelers, it is recommended to take 400 mg per day 1 day before departure, during the entire trip and 2 days after its completion (no more than 21 days).

For the prevention of sepsis with neutropenia, 400 mg is prescribed 2 times a day for up to 8 weeks.

In acute uncomplicated cystitis, 400 mg is prescribed 2 times a day for 3-5 days.

For the prevention of recurrent uncomplicated urinary tract infections with frequent exacerbations (more than 3 episodes per year or more than 2 within six months), the drug is prescribed 200 mg (1/2 tablet of Nolicin) 1 time per night for a long time (from 6 months to several years).

Patients with impaired renal function with creatinine clearance greater than 20 ml / min do not need to adjust the dosage regimen. When creatinine clearance is less than 20 ml / min (or serum creatinine level is higher than 5 mg / 100 ml) and hemodialysis patients are prescribed half the therapeutic dose of Nolicin 2 times a day or the full dose of the drug 1 time per day.

Side effects of the

From the digestive system: decreased appetite, bitterness in the mouth, nausea, vomiting, abdominal pain, diarrhea, pseudomembranous enterocolitis (with prolonged use), increased activity of “liver” transaminases.

From the urinary system: crystalluria, glomerulonephritis, dysuria, polyuria, albuminuria, urethral bleeding, increased urea and creatinine in blood plasma.

From the nervous system: headache, dizziness, fainting, insomnia, hallucinations. In elderly patients, the following are possible: fatigue, drowsiness, anxiety, irritability, fear, depression, tinnitus.

From the cardiovascular system: tachycardia, arrhythmias, lowering blood pressure, vasculitis.

Allergic reactions: rash, pruritus, urticaria, edema, malignant exudative erythema (Stevens-Johnson syndrome).

From the musculoskeletal system: arthralgia, tendonitis, tendon rupture (usually in the case of a combination with contributing factors).

From the hemopoietic system: eosinophilia, leukopenia, decreased hematocrit.

Other: candidiasis.

Overdose

If you overdose, you may experience the following symptoms: nausea, vomiting, diarrhea. In severe cases: dizziness, drowsiness, "cold" sweat, convulsions, puffy face without changing the basic hemodynamic indications.

Treatment: gastric lavage, adequate hydration therapy with forced diuresis and symptomatic therapy. Inpatient examination and observation within a few days is required. There is no specific antidote.

Storage conditions

In a dry, dark place at a temperature of no higher than 25 ° C. Keep out of reach of children.

Expiration

5 years.

Deystvuyuschee substances

norfloxacin



pharmacy terms and conditions

prescription

dosage form

dosage form

tablets

KRKA d.d. Novo mesto AO, Slovenia



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