OKI rectal suppository 160 mg, 10 pcs. (Ketoprofen)
Special Price
$22.10
Regular Price
$26.00
In stock
SKU
newyork461784
Release form
Suppositories. Buy OKI rectal suppository 160 mg, 10 pcs. (Ketoprofen) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Suppositories. Buy OKI rectal suppository 160 mg, 10 pcs. (Ketoprofen) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Release form
Suppositories.
Packaging
There are 5 suppositories in a foil strip. There are 2 strips in the package.
Pharmacological action
OKI - anti-inflammatory, antipyretic, analgesic. The anti-inflammatory mechanism is associated with impaired synthesis of prostanoids (the main inflammatory mediators) from arachidonic acid by blockade of cyclooxygenase type I and II. In addition, the drug inhibits the production of leukotrienes with chemotactic effects. In the spectrum of action of the drug there are also anti-bradykinin activity. It stabilizes lysosomal membranes and delays the release of enzymes from them that contribute to tissue destruction in chronic inflammation. Reduces the activity of cytokines, inhibits the activity of neutrophils (cytokines, especially interleukin 1 and tumor necrosis factor, released upon activation of neutrophils, play a decisive role in inflammatory tissue damage).
The analgesic effect of AKI is determined by its direct and indirect effect on pain receptors at the level of synapses and in the central nervous system. Indirect peripheral antinociceptive action is associated, firstly, with inhibition of GHG synthesis, which increase the sensitivity of free nerve endings to irritants (GHGs also enhance the effect of other inflammatory mediators). Secondly, an important component of the pronounced peripheral analgesic effect of OCI is its bradykinin activity (bradykinin is one of the most powerful endogenous substances that contribute to the development of pain). OKI also has a direct effect on pain receptors, which consists in the depolarization of ion channels, due to which a quick effect on the pain reaction is realized. The central effect of OCI is determined by a change in the configuration of the G protein located on the postsynaptic membrane of neurons. Thus, the afferent signal of pain is reduced.
etc.) ENT and odonto-dental diseases (tonsillitis, laryngitis, pharyngitis, tonsillitis, otitis media, stomatitis, gingivitis, glossitis, aphthae, periodontitis, x Ronic periodontal disease) an aid in the treatment and extraction of teeth.
Contraindications
Hypersensitivity (including to other NSAIDs).
Aspirin asthma.
Peptic ulcer of the stomach and duodenum (exacerbation).
Ulcerative colitis (exacerbation).
Crohn's disease.
Diverticulitis.
Peptic ulcer.
Hemophilia and other blood clotting disorders.
Chronic renal failure.
Children's age (up to 18 years).
Pregnancy (III trimester).
Lactation.
Caution:
Anemia.
Bronchial asthma.
Alcoholism.
smoking.
Alcoholic cirrhosis of the liver.
Hyperbilirubinemia.
Hepatic failure.
Diabetes mellitus.
Dehydration.
sepsis.
Chronic heart failure.
Edema.
Arterial hypertension.
Diseases of the blood, including leukopenia.
Deficiency of glucose-6-phosphate dehydrogenase.
Stomatitis.
Old age.
Pregnancy (I, II trimester).
If the patient worsens, discontinue treatment with the drug.
Pregnancy and lactation
Like other NSAIDs, OCI should not be used in the third trimester of pregnancy. The use of the drug in the I and II trimester should be carefully monitored by the attending physician.
Breastfeeding should be discontinued while using the drug.
Special instructions
During treatment, monitoring of the picture of peripheral blood and the functional state of the liver and kidneys is necessary.
If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study.
Ketoprofen may mask signs of an infectious disease.
In case of impaired renal and hepatic function, dose reduction and close monitoring are necessary.
The use of ketoprofen in patients with bronchial asthma can lead to an attack of bronchial asthma.
Women planning a pregnancy should refrain from taking the drug, as the probability of egg implantation may be reduced.
Influence on the ability to drive vehicles and control mechanisms
During the period of use of the drug, one should refrain from potentially dangerous activities associated with the need for concentration and quick psychomotor reactions.
Composition
Active ingredient:
Ketoprofen lysine salt 160 mg.
Excipients:
Semi-synthetic glycerides 1640 mg.
Dosage and administration of
Adults: 1 suppository 2-3 times a day. The maximum daily dose is 480 mg. In elderly patients, it is necessary to use no more than 2 suppositories per day.
Side effects of the
From the gastrointestinal tract:
Abdominal pain, diarrhea, duodenitis, erosive and ulcerative lesions of the gastrointestinal tract, gastritis, hematomesis, esophagitis, stomatitis, melena.
From the liver:
Increased bilirubin, increased liver enzymes, hepatitis, liver failure, increased liver size.
From the nervous system:
Dizziness, Hyperkinesis, tremor, Vertigo, mood swings, anxiety, hallucinations, irritability, general malaise.
From the sensory organs:
Conjunctivitis, visual impairment.
From the skin:
Urticaria, angioneurotic edema, erythematous exanthema, pruritus, maculopapular exanthema, increased sweating, erythema multiforme exudative (including Stevens-Johnson syndrome).
From the genitourinary system:
Painful urination, cystitis, swelling, hematuria, irregular menstruation.
Hematopoietic organs:
Leukocytopenia, leukocytosis, lymphangitis, decreased prothrombin time, purpura, thrombocytopenia, thrombocytopenic purpura, enlarged spleen, vasculitis.
From the respiratory system:
Bronchospasm, dyspnea, sensation of laryngeal spasm, laryngospasm, laryngeal edema, rhinitis.
From the cardiovascular system:
Hypertension, hypotension, tachycardia, chest pain, syncope, peripheral edema, pallor.
Allergic reactions:
Anaphylactoid reactions, swelling of the oral mucosa, swelling of the pharynx, periorbital edema.
Local reactions:
Burning, itching, severity in the anorectal region, exacerbation of hemorrhoids.
Drug interaction
With the simultaneous use of anticoagulants, diphenylhydantoin or sulfonamides, their dosage must be reduced. Concomitant use with acetylsalicylic acid or other NSAIDs is not recommended.
Overdose
No cases of overdose with OCI have been reported at this time.
Storage conditions
Do not store above 25 ° C.
Shelf life
5 years.
Deystvuyushtee substance
Ketoprofen
Terms and conditions
without prescription
dosage form
rectal suppositories
Possible product names
OKI 0.16 N10 SUPP
OKI 0.16 N10 SUPP RECT
OKI 160mg rectal suppositories X10 (R)
OKI rectal suppository 160 mg, 10 pcs.
OKI supp rekt 160mg N10
Dumpé, Italy
OKI rectal suppository 160 mg, 10 pcs. (Ketoprofen) newyork in pharmacy online. Cheap price, instruction, side effects, dosage. OKI rectal suppository 160 mg, 10 pcs. - Sale. PayPal accept. Free shipping newyork. Fast international shipping.
Suppositories.
Packaging
There are 5 suppositories in a foil strip. There are 2 strips in the package.
Pharmacological action
OKI - anti-inflammatory, antipyretic, analgesic. The anti-inflammatory mechanism is associated with impaired synthesis of prostanoids (the main inflammatory mediators) from arachidonic acid by blockade of cyclooxygenase type I and II. In addition, the drug inhibits the production of leukotrienes with chemotactic effects. In the spectrum of action of the drug there are also anti-bradykinin activity. It stabilizes lysosomal membranes and delays the release of enzymes from them that contribute to tissue destruction in chronic inflammation. Reduces the activity of cytokines, inhibits the activity of neutrophils (cytokines, especially interleukin 1 and tumor necrosis factor, released upon activation of neutrophils, play a decisive role in inflammatory tissue damage).
The analgesic effect of AKI is determined by its direct and indirect effect on pain receptors at the level of synapses and in the central nervous system. Indirect peripheral antinociceptive action is associated, firstly, with inhibition of GHG synthesis, which increase the sensitivity of free nerve endings to irritants (GHGs also enhance the effect of other inflammatory mediators). Secondly, an important component of the pronounced peripheral analgesic effect of OCI is its bradykinin activity (bradykinin is one of the most powerful endogenous substances that contribute to the development of pain). OKI also has a direct effect on pain receptors, which consists in the depolarization of ion channels, due to which a quick effect on the pain reaction is realized. The central effect of OCI is determined by a change in the configuration of the G protein located on the postsynaptic membrane of neurons. Thus, the afferent signal of pain is reduced.
etc.) ENT and odonto-dental diseases (tonsillitis, laryngitis, pharyngitis, tonsillitis, otitis media, stomatitis, gingivitis, glossitis, aphthae, periodontitis, x Ronic periodontal disease) an aid in the treatment and extraction of teeth.
Contraindications
Hypersensitivity (including to other NSAIDs).
Aspirin asthma.
Peptic ulcer of the stomach and duodenum (exacerbation).
Ulcerative colitis (exacerbation).
Crohn's disease.
Diverticulitis.
Peptic ulcer.
Hemophilia and other blood clotting disorders.
Chronic renal failure.
Children's age (up to 18 years).
Pregnancy (III trimester).
Lactation.
Caution:
Anemia.
Bronchial asthma.
Alcoholism.
smoking.
Alcoholic cirrhosis of the liver.
Hyperbilirubinemia.
Hepatic failure.
Diabetes mellitus.
Dehydration.
sepsis.
Chronic heart failure.
Edema.
Arterial hypertension.
Diseases of the blood, including leukopenia.
Deficiency of glucose-6-phosphate dehydrogenase.
Stomatitis.
Old age.
Pregnancy (I, II trimester).
If the patient worsens, discontinue treatment with the drug.
Pregnancy and lactation
Like other NSAIDs, OCI should not be used in the third trimester of pregnancy. The use of the drug in the I and II trimester should be carefully monitored by the attending physician.
Breastfeeding should be discontinued while using the drug.
Special instructions
During treatment, monitoring of the picture of peripheral blood and the functional state of the liver and kidneys is necessary.
If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study.
Ketoprofen may mask signs of an infectious disease.
In case of impaired renal and hepatic function, dose reduction and close monitoring are necessary.
The use of ketoprofen in patients with bronchial asthma can lead to an attack of bronchial asthma.
Women planning a pregnancy should refrain from taking the drug, as the probability of egg implantation may be reduced.
Influence on the ability to drive vehicles and control mechanisms
During the period of use of the drug, one should refrain from potentially dangerous activities associated with the need for concentration and quick psychomotor reactions.
Composition
Active ingredient:
Ketoprofen lysine salt 160 mg.
Excipients:
Semi-synthetic glycerides 1640 mg.
Dosage and administration of
Adults: 1 suppository 2-3 times a day. The maximum daily dose is 480 mg. In elderly patients, it is necessary to use no more than 2 suppositories per day.
Side effects of the
From the gastrointestinal tract:
Abdominal pain, diarrhea, duodenitis, erosive and ulcerative lesions of the gastrointestinal tract, gastritis, hematomesis, esophagitis, stomatitis, melena.
From the liver:
Increased bilirubin, increased liver enzymes, hepatitis, liver failure, increased liver size.
From the nervous system:
Dizziness, Hyperkinesis, tremor, Vertigo, mood swings, anxiety, hallucinations, irritability, general malaise.
From the sensory organs:
Conjunctivitis, visual impairment.
From the skin:
Urticaria, angioneurotic edema, erythematous exanthema, pruritus, maculopapular exanthema, increased sweating, erythema multiforme exudative (including Stevens-Johnson syndrome).
From the genitourinary system:
Painful urination, cystitis, swelling, hematuria, irregular menstruation.
Hematopoietic organs:
Leukocytopenia, leukocytosis, lymphangitis, decreased prothrombin time, purpura, thrombocytopenia, thrombocytopenic purpura, enlarged spleen, vasculitis.
From the respiratory system:
Bronchospasm, dyspnea, sensation of laryngeal spasm, laryngospasm, laryngeal edema, rhinitis.
From the cardiovascular system:
Hypertension, hypotension, tachycardia, chest pain, syncope, peripheral edema, pallor.
Allergic reactions:
Anaphylactoid reactions, swelling of the oral mucosa, swelling of the pharynx, periorbital edema.
Local reactions:
Burning, itching, severity in the anorectal region, exacerbation of hemorrhoids.
Drug interaction
With the simultaneous use of anticoagulants, diphenylhydantoin or sulfonamides, their dosage must be reduced. Concomitant use with acetylsalicylic acid or other NSAIDs is not recommended.
Overdose
No cases of overdose with OCI have been reported at this time.
Storage conditions
Do not store above 25 ° C.
Shelf life
5 years.
Deystvuyushtee substance
Ketoprofen
Terms and conditions
without prescription
dosage form
rectal suppositories
Possible product names
OKI 0.16 N10 SUPP
OKI 0.16 N10 SUPP RECT
OKI 160mg rectal suppositories X10 (R)
OKI rectal suppository 160 mg, 10 pcs.
OKI supp rekt 160mg N10
Dumpé, Italy
OKI rectal suppository 160 mg, 10 pcs. (Ketoprofen) newyork in pharmacy online. Cheap price, instruction, side effects, dosage. OKI rectal suppository 160 mg, 10 pcs. - Sale. PayPal accept. Free shipping newyork. Fast international shipping.
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