Omnitus syrup 0.8 mg / ml, 200 ml (butamirate)

Latin name

Omnitus

Release form

Intake syrup

Packing

Bottle 200 ml.

Pharmacological action

Antitussive, has an expectorant, moderate bronchodilating and anti-inflammatory effect.

Butamyrate citrate is neither chemically nor pharmacologically related to opium alkaloids and has a direct effect on the cough center, improves spirometry and blood oxygenation.

Pharmacokinetics

Absorption - High. After ingestion of a syrup in a dose containing 150 mg of butyrate citrate, the maximum plasma concentration of the main metabolite (2-phenylbutyric acid) is observed after 1.5 hours and amounts to 6.4 μg / ml, when taking a tablet with a modified release (50 mg), respectively, - 9 h and 1. 4 mcg / ml. The half-life for syrup is 6 hours, for tablets - 13 hours. There is no cumulative effect. Butamyrate citrate is rapidly hydrolyzed in plasma to 2-phenylbutyric acid and diethylaminoethoxyethanol. Both of these metabolites, which also have an antitussive effect, are largely bound to plasma proteins, which explains their prolonged presence in plasma. Subsequently, the main metabolite of 2-phenylbutyric acid is oxidized to 14C-p-hydroxy-2-phenylbutyric acid. All three metabolites are excreted by the kidneys, and acidic metabolites are mainly associated with glucuronic acid.

Indications

Dry cough of any etiology (for colds, flu, whooping cough and other conditions). Cough suppression in the preoperative and postoperative period, during surgical interventions, bronchoscopy.

Contraindications

Hypersensitivity, pregnancy (I trimester), lactation, children under 3 years old.

Use during pregnancy and lactation

The use of the drug in the form of syrup during pregnancy is contraindicated, in the form of tablets in the first trimester of pregnancy.

If you need to use the drug during lactation, you should decide whether to stop breastfeeding.

Composition of

1 ml of syrup contains: Active ingredient

Butamirate citrate 0.8 mg

Excipients

Sorbitol 70% (non-crystallizing) - 405.00 mg, glycerol - 290.00 mg, sodium saccharin - 0.60 mg, benzoic acid - 1.15 mg, vanillin - 0.60 mg, anise oil - 0.15 mg, ethanol 96% - 3.00 μl, sodium hydroxide - 0.10 mg, purified water - up to 1.00 ml.

Dosage and administration

Syrup contains 1 scoop (5 ml):

Adults - 6 scoops (30 ml) 3 times a day.

Children over 9 years old (40 kg) - 3 measured spoons (15 ml) 4 times a day from 6 to 9 years (22-30 kg) - 3 measured spoons (15 ml) 3 times a day from 3 to 6 years ( 15-22 kg) - 2 measured spoons (10 ml) 3 times a day.

Side effects

From the digestive system: nausea, diarrhea.

Other: exanthema, dizziness, allergic reactions.

Overdose

Symptoms: nausea, vomiting, drowsiness, diarrhea, dizziness, decreased blood pressure.

Treatment: activated charcoal, salt laxatives, if necessary - carrying out symptomatic therapy.

Storage Conditions

At 15 ° C to 25 ° C.

shelf life

5 years

Deystvuyushtee substance

Butamirate

Terms and conditions

without prescription

dosage form

oral solution

Possible product names

OMNITUS 0,0008 / ML 200ML FLAC SYRUP

Omnitus 0.8mg / ml 200ml syrup

Omnitus 0.8mg / ml syrup 200ml Fl.t / s B M

Omnitus syrup. 0.8mg / ml 200ml with mer. Serbia

Omnitus syrup 0.8 mg / ml 200 ml (with a measuring spoon)



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