Omnitus tablets are coated.plen.ob.s with mod.vysvv. 50 mg 10 pcs. (butamirate)

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newyork469531
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Latin name

Omnitus Buy Omnitus tablets are coated.plen.ob.s with mod.vysvv. 50 mg 10 pcs. (butamirate) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Latin name

Omnitus

Pharmacological action

Antitussive, has an expectorant, moderate bronchodilating andanti-inflammatory effect.

Butamyrate citrate is neither chemically nor pharmacologically related to opium alkaloids and has a direct effect on the cough center, improves spirometry and blood oxygenation.

Pharmacokinetics

Absorption - High. After ingestion of a syrup in a dose containing 150 mg of butyrate citrate, the maximum plasma concentration of the main metabolite (2-phenylbutyric acid) is observed after 1.5 hours and amounts to 6.4 μg / ml, when taking a tablet with a modified release (50 mg), respectively, - 9 h and 1.4 μg / ml. The half-life for syrup is 6 hours, for tablets - 13 hours. There is no cumulative effect. Butamyrate citrate is rapidly hydrolyzed in plasma to 2-phenylbutyric acid and diethylaminoethoxyethanol. Both of these metabolites, which also have an antitussive effect, largely bind to plasma proteins, which explains their prolonged presence in plasma. Subsequently, the main metabolite of 2-phenylbutyric acid is oxidized to 14C-p-hydroxy-2-phenylbutyric acid. All three metabolites are excreted by the kidneys, and acidic metabolites are mainly associated with glucuronic acid.

Indications

Dry cough of any etiology (for colds, flu, whooping cough and other conditions) to suppress cough in the preoperative and postoperative period, during surgery, bronchoscopy.

Contraindications

hypersensitivity

pregnancy

lactation

children under 18 years of age

Use during pregnancy and lactation

The use of the drug in the form of syrup during pregnancy is contraindicated, in the form of tablets in the first trimester of pregnancy.

If you need to use the drug during lactation, you should decide whether to stop breastfeeding.

Composition

1 tablet with a modified release film-coated

50 mg contains:

Active ingredient

Butyramide citrate 50 mg

Excipients

mg lactose 230 mg lactose , 0 mg, talc - 10.0 mg, magnesium stearate - 12.0 mg, silicon dioxide colloidal, anhydrous - 6.0 mg, povidone - 1.5 mg,

Shell composition

hypromellose - 5.305 mg, talc - 4.950 mg ethyl cellulose - 3.183 mg, macrogol - 1.273 mg, titanium dioxide - 1.061 mg, crimson dye [Ponceau 4R] [E 124] - 2.122 g brown varnish (sunset yellow dye [E110], a colorant azorubin [E122], black dye [E151]) - 0.106 mg.

Dosage and Administration

Inside. Tablets are taken before meals, without chewing.

Tablets, 50 mg

Adults - 2 tablets. 2-3 times a day.

Side effects

From the digestive system: nausea, diarrhea.

Other: exanthema, dizziness, allergic reactions.

Overdose

Symptoms: nausea, vomiting, drowsiness, diarrhea, dizziness, decreased blood pressure.

Treatment: inside - activated charcoal, saline laxatives, if necessary - symptomatic therapy.

Storage Conditions

At 15 ° C to 25 ° C.

Term hodnosty

2 years

active substance

butamirata

Terms leave through pharmacies

without prescription

Dosage form

tablet prolong.



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