Osteogenon tablets 830 mg, 40 pcs. (Osteohenon)

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newyork461598
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Release form

film-coated tablets. Buy Osteogenon tablets 830 mg, 40 pcs. (Osteohenon) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Release form

film-coated tablets.

Packaging

40 pcs.

Pharmacological action

Calcium-phosphorus metabolism regulator used in systemic osteoporosis.

The drug has a dual effect on bone metabolism: a stimulating effect on osteoblasts and an inhibitory effect on osteoclasts. Osteogenon contains the necessary components for the synthesis of bone tissue.

Calcium, which is part of the preparation, is contained in the form of hydroxyapatite (in the ratio of phosphorus 2: 1), which contributes to a more complete absorption of calcium from the gastrointestinal tract, in addition, it inhibits the production of parathyroid hormone and prevents hormone-mediated bone resorption. Slow release of calcium from hydroxyapatite causes the absence of a peak in hypercalcemia.

Phosphorus involved in the crystallization of hydroxyapatite, promotes fixation of calcium in the bone and inhibits its excretion by the kidneys.

The organic component of the drug (ossein) contains local bone remodeling regulators (transforming growth factor beta (b-TGF), insulin-like growth factors I, II (IGF-I, IGF-II), osteocalcin, type I collagen) that activate the process of bone formation and inhibit bone resorption. b-TGF stimulates the activity of osteoblasts, increases their number, promotes collagen production, and also inhibits the formation of osteoclast precursors. IGF-I and IGF-II stimulate the synthesis of collagen and osteocalcin. Osteocalcin promotes crystallization of bone by binding calcium. Collagen of the first type provides the formation of a bone matrix.

Indications

- prevention and treatment of osteoporosis of various etiologies, including primary (premenopausal, climacteric, senile) and secondary (due to rheumatoid arthritis, liver and kidney diseases, hyperthyroidism, hyperparathyroidism, imperfect bone formation, as well as the use of corticosteroids, heparin, immobilization)

- correction of osteopenia and calcium-phosphorus imbalance. h during pregnancy and during breastfeeding)

- accelerating the healing of bone fractures.

Contraindications

- hypercalcemia

- severe hypercalciuria

- hypersensitivity to the drug.

Use during pregnancy and lactation

It is possible to use Osteogenon during pregnancy and during lactation (breastfeeding) according to indications.

When used during pregnancy, the drug does not have a damaging effect on the fetus.

Special instructions

In patients predisposed to urolithiasis, correction of the dosage regimen of the drug is necessary.

In patients with impaired renal function, prolonged use of the drug in high doses should be avoided.

The composition of the drug includes only trace amounts of sodium chloride, so the use of Osteogenon in patients with arterial hypertension is permissible.

Composition

1 tab. contains ossein-hydroxyapatite compound 830 mg.

Dosage and administration of

In osteoporosis, adults are prescribed 2-4 tablets orally. 2 times / day

For other indications, the recommended dose is 1-2 tablets / day.

Duration of treatment is determined by the condition of the patient.

Side effects

Rarely: allergic reaction.

Drug interaction

When used together, Osteogenon slows down the absorption of iron preparations and tetracycline antibiotics (the interval between doses should be at least 4 hours).

Overdose

Treatment of asymptomatic hypercalcemia (see section “Administration and dosage”).

Since Rockaltrol® is a derivative of vitamin D, it is characterized by the same symptoms of overdose. Taking large doses of calcium and phosphate together with Rockaltrol® can cause similar symptoms. The product of serum calcium and phosphorus (CaxP) concentration should not exceed 70 mg2 / dl2. The development of hypercalcemia can be facilitated by the high calcium content of dialysate.

Symptoms of acute vitamin D poisoning: anorexia, headache, vomiting, constipation.

Symptoms of chronic poisoning: dystrophy (weakness, weight loss), sensitivity disorders, fever with thirst, polyuria, dehydration, apathy, growth retardation and urinary tract infections are possible. The consequences of hypercalcemia are focal calcification of the cortical layer of the kidneys, myocardium, lungs, and pancreas.

Treatment of accidental overdose: immediate gastric lavage or vomiting to prevent further ingestion. Vaseline oil is used as a laxative to remove the drug with feces. It is recommended to re-determine serum calcium levels. If persistent serum calcium levels persist, phosphates and corticosteroids may be prescribed, and adequate diuresis may be taken.

Storage conditions

The product should be stored at room temperature (not above 30 ° C), out of the reach of children.

Shelf life

4 years.

Deystvuyushtee substance

Osteogenon

dosage form

tablets

Possible product names

OSTEOGENON TON 0.83 Nrd 0.8 Nrd 0.83 Nrd 0.83 Nrd 0.83

Osteogenon 830 mg Tab p / o X40 / until 10.2007 /

Osteogenon 830 mg Tab. P / o X40

Osteogenon 830mg No. 40 tab

Pyer Fabre Medicament France



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