Pantogam syrup 10%, 100 ml (Hopantenovaya acid)

Release form

Syrup

Packing

Bottle 100 ml.

Pharmacological action

The spectrum of action of Pantogam® is associated with the presence of gamma-aminobutyric acid (GABA) in its structure. The mechanism of action is due to the direct effect of the drug on the GABAA-receptor-channel complex.

Has a nootropic and anticonvulsant effect. Increases brain resistance to hypoxia and the effects of toxic substances, stimulates anabolic processes in neurons, combines moderate sedative effect with a mild stimulating effect, reduces motor excitability, activates mental and physical performance.

Improves the metabolism of GABA in chronic alcohol intoxication and after discontinuation of ethanol.

Able to inhibit acetylation reactions involved in the inactivation of procaine (novocaine) and sulfonamides, due to which the prolongation of the action of the latter is achieved. Causes inhibition of pathologically increased cystic reflex and detrusor tone.

Pharmacokinetics

Pantogam® is rapidly absorbed from the gastrointestinal tract, passes through the BBB, and the highest concentrations are created in the liver, kidneys, stomach wall and skin. It is not metabolized and excreted unchanged within 48 hours: 67.5% of the dose taken is excreted in the urine, 28.5% - with feces.

Indications of

cognitive impairment in organic brain lesions (including consequences of neuroinfections and head injury) and neurotic disorders

schizophrenia with cerebral organic insufficiency

cerebrovascular insufficiency caused by atherosclerotic cerebrovascular disease Huntington, hepatolenticular degeneration, Parkinson's disease, etc.)

treatment and prevention of extrapyramidal syndrome (hyperkinetically and akinetic) neuroleptics caused by

neuroleptics with mental retardation in combination therapy with anticonvulsants

psychoemotional overload

decreased mental and physical performance, to improve concentration and memory

neurogenic disorders of urination (pollakiuria, imperative urination).

in children with perinatal encephalopathy

mental retardation of varying severity in children

developmental delay (mental, speech, motor or a combination of them) in children

various forms of cerebral palsy

hyperkinetic disorders (attention deficit hyperactivity disorder in children) (when stuttering, mainly in clonic form, ticks) in children.

Contraindications

hypersensitivity

acute severe kidney disease

pregnancy (I trimester - syrup)

pregnancy (tablets)

phenylketonuria (syrup, contains aspartame)

period of breastfeeding (tablets).

children's age up to 3 years (tablets).

Special instructions

Information on the possible effect of the drug on the ability to drive vehicles and mechanisms.

In the early days of admission, care should be taken when driving vehicles and machinery, considering the possible occurrence of drowsiness

Ingredients

Active ingredient:

calcium hopantenate - 10 g

Excipients:

glycerol,

sorbate sodium,

sodium sorbate, food sorblit ,

aspartame,

essence aromatic food Separated,

purified water

Dosage and administration of

Adults: single dose - 2.5-10 ml (0.25-1 g), daily - 15-30 ml (1.5-3 g) for children: single dose - 2.5– 5 ml (0.25–0.5 g), daily - 7.5–30 ml (0.75–3 g). The course of treatment is 1–4 months, sometimes up to 6 months. After 3-6 months, a second course of treatment is possible.

For children, depending on the age and pathology of the nervous system, the following dose range is recommended: for children of the first year - 5–10 ml (0.5–1 g) per day, up to 3 years - 5–12.5 ml (0.5 –1.25 g) per day, for children from 3 to 7 years old - 7.5–15 ml (0.75–1.5 g), over 7 years old - 10–20 ml (1–2 g). The tactics of treatment include increasing the dose within 7-12 days, taking the maximum dose for 15-40 days or more with a gradual decrease in dose until withdrawal within 7-8 days. The course of treatment is 30–90 days (for certain diseases up to 6 months or more).

In schizophrenia in combination with psychotropic drugs - from 5 to 30 ml (0.5–3 g) per day. The course of therapy is from 1 to 3 months.

With epilepsy in combination with anticonvulsants - in a dose of 7, 5 to 10 ml (0.75–1 g) per day. The course of therapy is up to 1 year or more.

With a neuroleptic syndrome accompanied by extrapyramidal disorders, the daily dose is up to 30 ml (up to 3 g), treatment for several months.

In extrapyramidal hyperkinesis in patients with organic diseases of the nervous system - from 5 to 30 ml (0.5–3 g) per day. The course of treatment is up to 4 months or more.

With the consequences of neuroinfections and head injury - from 5 to 30 ml (0.5–3 g) per day.

To restore performance under increased loads and asthenic conditions - 2.5–5 ml (0.25–0.5 g) 3 times a day.

In case of urination disorders for children - 2.5–5 ml (0.25–0.5 g) daily dose - 25–50 mg / kg, course of treatment - 1-3 months for adults –– 5–10 ml (0 5–1 g) 2-3 times a day.

In conditions of prolonged treatment, the simultaneous administration of the drug with other nootropic and stimulating agents is not recommended. Given the nootropic effect of the drug, its administration is preferably carried out in the morning and afternoon.

Side effects

Allergic reactions: rhinitis, conjunctivitis, skin rashes are possible.

Other: sleep disturbances or drowsiness, tinnitus are possible (these symptoms are usually short-term and do not require discontinuation of the drug).

Drug interaction

It prolongs the action of barbiturates, enhances the action of anticonvulsants, prevents side effects of phenobarbital, carbamazepine, antipsychotics.

Potentiates the action of local anesthetics (procaine).

The effect of Pantogam® is enhanced in combination with glycine, ethidronic acid (xidiphon).

Overdose

Symptoms: increased symptoms of side effects (sleep disturbance or drowsiness, noise in the head).

Treatment: administration of activated carbon, gastric lavage, symptomatic therapy.

Storage Conditions

The product should be stored in a dark place at 15 ° C to 20 ° C.

Expiration

1.5 years

Active ingredient

hopantenic acid

Terms leave through pharmacies

In retseptu

lekarstvennaja form

Solution for pryema inside

Pik-Pharma, Russia



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