Pantogam tablets 250 mg, 50 pcs. (Hopantenovaya acid)

Release form

tablets

Packing

50 pcs.

Pharmacological action

The spectrum of action of Pantogam® is associated with the presence in its structuregamma-aminobutyric acid (GABA). The mechanism of action is due to the direct effect of the drug on the GABAA-receptor-channel complex.

Has a nootropic and anticonvulsant effect. Increases brain resistance to hypoxia and toxic substances, stimulates anabolic processes in neurons, combines moderate sedative effect with a mild stimulating effect, reduces motor excitability, activates mental and physical performance.

Improves the metabolism of GABA in chronic alcohol intoxication and after discontinuation of ethanol.

Able to inhibit acetylation reactions involved in the inactivation of procaine (novocaine) and sulfonamides, due to which the prolongation of the action of the latter is achieved. Causes inhibition of pathologically increased cystic reflex and detrusor tone.

Pharmacokinetics

Pantogam® is rapidly absorbed from the gastrointestinal tract, passes through the BBB, and the highest concentrations are created in the liver, kidneys, stomach wall and skin. It is not metabolized and excreted unchanged within 48 hours: 67.5% of the dose taken is excreted in the urine, 28.5% - with feces.

Indications of

cognitive impairment in organic brain lesions (including the effects of neuroinfections and head injury) and neurotic disorders

schizophrenia with cerebral organic insufficiency

cerebrovascular insufficiency caused by atherosclerotic cerebrovascular disease Huntington, hepatolenticular degeneration, Parkinson's disease, etc.)

treatment and prevention of extrapyramidal syndrome (hyperkinetically and akinetic) caused by taking neuroleptics

epilepsy with mental retardation processes in the complex therapy with anticonvulsants

psycho-emotional overload

reduced mental and physical performance, to improve concentration and memorization

neurogenic disorders of urination (pollakiuria, peremptory urge, imperative urinary incontinence, enuresis).

in children with perinatal encephalopathy

mental retardation of varying severity in children

developmental delay (mental, speech, motor or a combination of them) in children

various forms of cerebral palsy

hyperkinetic disorders (attention deficit hyperactivity disorder in children) (with stuttering, mainly in clonic form, ticks) in children.

Contraindications

hypersensitivity

acute severe kidney disease

pregnancy (I trimester - syrup)

pregnancy (tablets)

phenylketonuria (syrup, contains aspartame)

period of breastfeeding (tablets).

children's age up to 3 years (tablets).

Special instructions

Information about the possible effect of the drug on the ability to drive vehicles, mechanisms.

In the first days of admission, care should be taken when driving vehicles and mechanisms, given the possible occurrence of drowsiness



Composition Active ingredient:

calcium hopantenate (hopantenic acid or calcium salt of hopantenic acid) 250 mg

Excipients:

magnesium hydroxycarbonate

calcium stearate

talc

starch potent substance: potassium methyl cellulose,

calcium stearate,

magnesium hydroxycarbonate,

talcum

Dosage and administration of

Adults: single dose - 0.25–1 g, daily - 1.5–3 g for children: single dose - 0.25–0.5 g, daily - 0.75–3 g. The course of treatment is 1–4 months, in some cases - up to 6 months. After 3-6 months, a second course of treatment is possible.

With epilepsy in combination with anticonvulsants - 0.75–1 g / day. The course of treatment is up to 1 year or more.

In extrapyramidal neuroleptic syndrome in combination with the therapy, the daily dose is up to 3 g, treatment for several months.

In extrapyramidal hyperkinesis in patients with hereditary diseases of the nervous system (combined treatment) - 0.5–3 g / day. The course of treatment is up to 4 months or more.

With the consequences of neuroinfections and head injury - 0.25 g 3-4 times a day.

To restore performance under increased loads and asthenic conditions - 0.25 g 3 times a day.

For the treatment of extrapyramidal syndrome caused by the use of antipsychotics, adults - 0.5-1 g 3 times a day for children - 0.25-0.5 g 3-4 times a day. The course of treatment is 1-3 months.

At ticks: for children - 0.25–0, 5 g 3–6 times a day, for 1–4 months.

In case of urination disorders: for adults - 0.5–1 g 2-3 times a day for children –– 0.25–0.5 g (daily dose - 25–50 mg / kg). The course of treatment is 1-3 months.

For children with various pathologies of the nervous system, depending on age, the drug is recommended at a dose of 1-3 g. Tactics of prescribing the drug: increasing the dose for 7-12 days, taking the maximum dose for 15-40 days and gradually reducing the dose to Pantogam® withdrawal within 7–8 days. The break between Pantogam® course receptions, as for any other nootropic remedy, is from 1 to 3 months.

Side effects

Allergic reactions: rhinitis, conjunctivitis, skin rashes are possible.

Other: sleep disturbances or drowsiness, tinnitus are possible (these symptoms are usually short-term and do not require discontinuation of the drug).

Drug interaction

It prolongs the action of barbiturates, enhances the action of anticonvulsants, and prevents side effects of phenobarbital, carbamazepine, antipsychotics.

Potentiates the action of local anesthetics (procaine).

The effect of Pantogam® is enhanced in combination with glycine, ethidronic acid (xidiphon).

Overdose

Symptoms: increased symptoms of side effects (sleep disturbance or drowsiness, noise in the head).

Treatment: administration of activated carbon, gastric lavage, symptomatic therapy.

Storage Conditions

The product should be stored in a dark place at 15 ° C to 20 ° C.

Term hodnosty

3 years

active substance

hopantenic acid

drugstore terms

drugstore

lekarstvennaja form

tablets



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