Papaverine rectal suppositories 20 mg 10 pcs. (Papaverine)

Latin name

Papaverine

Packing

10 pcs

Pharmacological action

Papaverine is a myotropic antispasmodic.

Pharmacokinetics

Bioavailability of papaverine after rectal administration (according to preclinical studies) is about 25%. Communication with plasma proteins 90%. It is well distributed, penetrates histohematological barriers. Metabolized in the liver. The half-life (T1 / 2) is 0.5-2 hours (an increase of up to 24 hours is possible). It is excreted by the kidneys in the form of metabolites.

Indications

Spasm of smooth muscles: abdominal organs (with cholecystitis, pylorospasm, spastic colitis) with renal colic of peripheral vessels (with endarteritis) of the cerebral vessels (with migraine) of the heart (with angina pectoris as part of complex therapy) bronchial bronchi ( )

Contraindications

Hypersensitivity to the drug, atrioventricular block, glaucoma, severe liver failure, old age (risk of hyperthermia), childhood, because the dosage regimen for children is not indicated.

With caution

Use with caution and in small doses in the condition after traumatic brain injury, chronic renal failure, adrenal insufficiency, hypothyroidism, prostatic hyperplasia, supraventricular tachycardia, shock conditions.

Use during pregnancy and lactation

During pregnancy and during lactation (breastfeeding), the safety and effectiveness of papaverine has not been established.

Composition

Composition per suppository: active ingredient: papaverine hydrochloride - 20 mg excipients: solid fat (Vitepsol (brands H 15, W 35), Supposir (brands NA 15, NAS 50)) - until a suppository weighs 1, 25 g.

Dosage and administration

Rectally. Having released the suppository from the contour packaging, it is introduced into the anus. Apply 1 suppository 2 to 3 times a day after spontaneous bowel movements or cleansing enemas.

Side effects

Allergic reactions, atrioventricular block, ventricular extrasystole, increased activity of hepatic transaminases, decreased blood pressure, drowsiness, constipation, eosinophilia are possible.

Drug Interaction

Reduces the effect of dopegite.

Efficiency decreases when smoking.

Storage Conditions

Store in a dark place.

Shelf life

2 years. Do not use the drug after the expiration date indicated on the package.

Deystvuyushtee substance

papaverine

Terms and conditions

without prescription

Dosage form a

rectal suppositories

Appointment

Appointment

Adult



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