Paracetamol Extratab 500 mg + 150 mg tablets 20 pcs. (Paracetamol, ascorbic acid)
Special Price
$18.70
Regular Price
$22.00
In stock
SKU
newyork826413
Latin name
PARACETAMOL EXTRATAB Buy Paracetamol Extratab 500 mg + 150 mg tablets 20 pcs. (Paracetamol, ascorbic acid) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
PARACETAMOL EXTRATAB Buy Paracetamol Extratab 500 mg + 150 mg tablets 20 pcs. (Paracetamol, ascorbic acid) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Latin name
PARACETAMOL EXTRATAB
Release form
Tablets from white to white with a yellowish tint, biconvex, oblong, with rounded ends, with a risk on one side, light marbling is allowed.
Pharmacological action
Combined analgesic drug
Paracetamol has analgesic and antipyretic effects. Blocks COX-1 and COX-2 mainly in the central nervous system, affecting the centers of pain and thermoregulation.
In inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on COX, which explains its almost complete absence of anti-inflammatory effect.
The drug does not adversely affect water-salt metabolism (sodium and water retention) and the gastrointestinal mucosa, due to the lack of effect on the synthesis of prostaglandins in peripheral tissues. The possibility of methemoglobin formation is unlikely.
Ascorbic acid (vitamin C) is not formed in the human body, it comes only with food.
Physiological functions: it is a cofactor of some reactions of hydroxylation and amidation - it transfers electrons to enzymes, supplying them with a reducing equivalent.
Participates in the hydroxylation of proline and lysine procollagen residues with the formation of hydroxyproline and hydroxylysine (post-translational modification of collagen), the oxidation of lysine side chains in proteins with the formation of hydroxytrimethyl lysine (in the process of the synthesis of kartit), the oxidation of folic acid to folinic microorganisms, metabolism hydroxylation of dopamine with the formation of norepinephrine.
Increases the activity of amidating enzymes involved in the processing of oxytocin, ADH and cholicystokinin. Participates in steroidogenesis in the adrenal glands.
The main role at the tissue level is the participation in the synthesis of collagen, proteoglycans and other organic components of the intercellular substance of teeth, bones and capillary endothelium.
Indications
Paracetamol EXTRATAB used as:
antipyretic for infectious and inflammatory diseases (SARS, including influenza)
analgesic for mild to moderate pain syndrome (headache, toothache) of non-inflammatory origin, with neuralgia, pain in muscles and joints, algodismenorrhea.
Contraindications
- severe kidney disease
- severe liver disease
- renal and / or hepatic insufficiency
- glucose-6-phosphate dehydrogenase deficiency
- erosive and ulcerative lesions of the gastrointestinal tract 6 years
- pregnancy
- lactation (breastfeeding).
Precautions: erosive and ulcerative lesions of the gastrointestinal tract (history), congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), blood diseases (thrombocytopenia, leukopenia, agranulocytosis), sideroblastic anemia, thalassemia hemochromatosis, and bronchial hemoxemia hemochromatosis.
Pregnancy and lactation
There are no data on the efficacy and safety studies of the combination of paracetamol and ascorbic acid in pregnant and lactating women.
Thus, it is not possible to assess the possible ratio of risk to benefit, and therefore the use of the drug in these categories of patients is not recommended.
Special instructions
The recommended doses of Paracetamol EXTRATAB should not be exceeded.
With hyperthermia lasting more than 3 days, and pain for more than 5 days, a doctor’s consultation is required.
After 5 days of using Paracetamol EXTRATAB, it is necessary to control the picture of peripheral blood and the functional state of the liver.
Paracetamol distorts laboratory tests when quantifying plasma glucose and uric acid concentrations.
In order to avoid toxic liver damage, paracetamol should not be combined with alcohol-containing drinks, and should also be taken by persons prone to alcohol abuse.
There is evidence that the frequent use of drugs containing paracetamol leads to aggravation of symptoms of bronchial asthma. The simultaneous use of other drugs should be agreed with the doctor.
Influence on the ability to drive vehicles and control mechanisms
There is no data on the effect of the drug Paracetamol EXTRATAB on the ability to drive vehicles and other technical means.
Composition
Active substances
paracetamol - 0.5 g
ascorbic acid - 0.15 g
rom hydrochloride ,
polyethylene glycol 6000 (macrogol 6000),
corn starch, sr dlkp stearic acid
Dosage and administration
Adults and children over 12 years of age (weighing more than 50 kg) should be taken orally 1 tablet 3-4 times a day with an interval between doses of 4-8 hours. Children from 6 to 12 years old - 1/2 tablet, the maximum daily dose - 2 tablets.
The maximum duration of treatment for children is 3 days.
The maximum duration of treatment for adults is not more than 5 days when prescribed as an anesthetic and not more than 3 days as an antipyretic.
Side effects of
Paracetamol
From the digestive system: rarely - nausea, very rarely - vomiting, diarrhea, epigastric pain, jaundice, pancreatitis and increased activity of liver enzymes.
Allergic reactions: rarely - skin rash, skin itching, urticaria, angioedema.
From the hemopoietic system and the lymphatic system: very rarely - anemia, leukopenia.
Other: weakness.
Ascorbic acid
Allergic reactions: skin rash, flushing of the skin.
Laboratory indicators: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia, glucosuria.
Drug Interactions
While taking other drugs with Paracetamol EXTRATAB, you should consult your doctor.
Paracetamol reduces the effectiveness of uricosuric drugs.
With prolonged and regular use, paracetamol potentiates the effects of warfarin and other coumarin derivatives and increases the risk of bleeding.
Concomitant use of colestyramine leads to a decrease in the absorption of paracetamol (and a weakening of the effects of paracetamol).
Metoclopramide and domperidone increase paracetamol absorption.
The simultaneous use of paracetamol and NSAIDs (including metamizole sodium, acetylsalicylic acid, ibuprofen) increases the risk of developing analgesic nephropathy and renal papillary necrosis, end-stage renal failure.
The simultaneous use of paracetamol and chloramphenicol may be accompanied by an increase in T1 / 2 of chloramphenicol up to 5 times.
Inducers of microsomal liver enzymes (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxication even with small overdoses.
Salicylamide increases T1 / 2 of paracetamol, which leads to the accumulation of paracetamol and, accordingly, increased formation of its toxic metabolites.
The simultaneous use of paracetamol and ethanol can enhance the hepatotoxicity of paracetamol, as well as contribute to the development of acute pancreatitis.
Diflunisal increases the plasma concentration of paracetamol by 50% - the risk of hepatotoxicity.
Other medicines containing paracetamol, as well as other non-narcotic analgesics, should not be used simultaneously. The simultaneous use of other medicines should be agreed with the doctor.
Ascorbic acid increases the blood concentration of benzylpenicillin and tetracyclines at a dose of 1 g / day, increases the bioavailability of ethinyl estradiol (including that which is part of oral contraceptives), improves the absorption of iron preparations in the intestines (converts ferric iron to divalent iron), while increasing iron excretion while use with deferoxamine reduces the effectiveness of heparin and indirect anticoagulants.
Acetylsalicylic acid, oral contraceptives, fresh juices and alkaline drink reduce the absorption and absorption of ascorbic acid. With simultaneous use with acetylsalicylic acid, urinary excretion of ascorbic acid increases and excretion of acetylsalicylic acid decreases.
Acetylsalicylic acid reduces the absorption of ascorbic acid by about 30%.
Ascorbic acid increases the risk of crystalluria in the treatment of short-acting salicylates and sulfanilamides, slows the excretion of acid by the kidneys, increases the excretion of drugs with an alkaline reaction (including alkaloids), and reduces the concentration of oral contraceptives in the blood.
Quinoline drugs, calcium chloride, salicylates, glucocorticosteroids, with prolonged use, deplete the reserves of ascorbic acid.
With the simultaneous use of ascorbic acid reduces the chronotropic effect of isoprenaline.
With long-term or high-dose use, ascorbic acid may interfere with the interaction of disulfiram and ethanol in high doses, increasing the excretion of mexiletine by the kidneys.
Barbiturates and primidone increase urinary excretion of ascorbic acid.
Ascorbic acid reduces the therapeutic effect of antipsychotic drugs (antipsychotics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.
Overdose
Paracetamol
Symptoms: during the first 24 hours after ingestion - pallor of the skin, nausea, vomiting anorexia, abdominal pain impaired glucose metabolism, metabolic acidosis.
Symptoms of liver dysfunction can occur 12-48 hours after overdose. In severe overdose - hepatic failure with progressive encephalopathy, coma, death acute renal failure with turbulent necrosis (including in the absence of severe liver damage) arrhythmia, pancreatitis. Hepatotoxic effect in adults is manifested with intake of 10 g or more. Rarely, liver failure develops rapidly and may be complicated by renal failure (tubular necrosis).
Treatment: administration of SH-group donors and precursors of glutathione - methionine synthesis - within 8-9 h after overdose and acetylcysteine - within 8 h. Need for additional therapeutic measures (further administration of methionine, (in / in the introduction of acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as the time elapsed after administration.
Ascorbic acid
Symptoms: diarrhea, nausea, irritation of the gastrointestinal mucosa, flatulence, abdominal pain of spastic nature, frequent urination, nephrolithiasis, insomnia, irritability, hypoglycemia.
Treatment: symptomatic, forced diuresis.
Storage Conditions
The product should be stored out of reach of children, in a dry, dark place at a temperature not exceeding 25 ° C.
Shelf life
2 years.
Active ingredient
Paracetamol, Ascorbic acid
Terms and conditions
without prescription
dosage form
tablets
Indications
Indications
headache, toothache pain, SARS, Myalgia, Influenza, Fever, Neuralgia
Paracetamol Extratab 500 mg + 150 mg tablets 20 pcs. (Paracetamol, ascorbic acid) florida in pharmacy online. Cheap price, instruction, side effects, dosage. Paracetamol Extratab 500 mg + 150 mg tablets 20 pcs. - Sale. PayPal accept. Free shipping florida. Fast international shipping.
PARACETAMOL EXTRATAB
Release form
Tablets from white to white with a yellowish tint, biconvex, oblong, with rounded ends, with a risk on one side, light marbling is allowed.
Pharmacological action
Combined analgesic drug
Paracetamol has analgesic and antipyretic effects. Blocks COX-1 and COX-2 mainly in the central nervous system, affecting the centers of pain and thermoregulation.
In inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on COX, which explains its almost complete absence of anti-inflammatory effect.
The drug does not adversely affect water-salt metabolism (sodium and water retention) and the gastrointestinal mucosa, due to the lack of effect on the synthesis of prostaglandins in peripheral tissues. The possibility of methemoglobin formation is unlikely.
Ascorbic acid (vitamin C) is not formed in the human body, it comes only with food.
Physiological functions: it is a cofactor of some reactions of hydroxylation and amidation - it transfers electrons to enzymes, supplying them with a reducing equivalent.
Participates in the hydroxylation of proline and lysine procollagen residues with the formation of hydroxyproline and hydroxylysine (post-translational modification of collagen), the oxidation of lysine side chains in proteins with the formation of hydroxytrimethyl lysine (in the process of the synthesis of kartit), the oxidation of folic acid to folinic microorganisms, metabolism hydroxylation of dopamine with the formation of norepinephrine.
Increases the activity of amidating enzymes involved in the processing of oxytocin, ADH and cholicystokinin. Participates in steroidogenesis in the adrenal glands.
The main role at the tissue level is the participation in the synthesis of collagen, proteoglycans and other organic components of the intercellular substance of teeth, bones and capillary endothelium.
Indications
Paracetamol EXTRATAB used as:
antipyretic for infectious and inflammatory diseases (SARS, including influenza)
analgesic for mild to moderate pain syndrome (headache, toothache) of non-inflammatory origin, with neuralgia, pain in muscles and joints, algodismenorrhea.
Contraindications
- severe kidney disease
- severe liver disease
- renal and / or hepatic insufficiency
- glucose-6-phosphate dehydrogenase deficiency
- erosive and ulcerative lesions of the gastrointestinal tract 6 years
- pregnancy
- lactation (breastfeeding).
Precautions: erosive and ulcerative lesions of the gastrointestinal tract (history), congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), blood diseases (thrombocytopenia, leukopenia, agranulocytosis), sideroblastic anemia, thalassemia hemochromatosis, and bronchial hemoxemia hemochromatosis.
Pregnancy and lactation
There are no data on the efficacy and safety studies of the combination of paracetamol and ascorbic acid in pregnant and lactating women.
Thus, it is not possible to assess the possible ratio of risk to benefit, and therefore the use of the drug in these categories of patients is not recommended.
Special instructions
The recommended doses of Paracetamol EXTRATAB should not be exceeded.
With hyperthermia lasting more than 3 days, and pain for more than 5 days, a doctor’s consultation is required.
After 5 days of using Paracetamol EXTRATAB, it is necessary to control the picture of peripheral blood and the functional state of the liver.
Paracetamol distorts laboratory tests when quantifying plasma glucose and uric acid concentrations.
In order to avoid toxic liver damage, paracetamol should not be combined with alcohol-containing drinks, and should also be taken by persons prone to alcohol abuse.
There is evidence that the frequent use of drugs containing paracetamol leads to aggravation of symptoms of bronchial asthma. The simultaneous use of other drugs should be agreed with the doctor.
Influence on the ability to drive vehicles and control mechanisms
There is no data on the effect of the drug Paracetamol EXTRATAB on the ability to drive vehicles and other technical means.
Composition
Active substances
paracetamol - 0.5 g
ascorbic acid - 0.15 g
rom hydrochloride ,
polyethylene glycol 6000 (macrogol 6000),
corn starch, sr dlkp stearic acid
Dosage and administration
Adults and children over 12 years of age (weighing more than 50 kg) should be taken orally 1 tablet 3-4 times a day with an interval between doses of 4-8 hours. Children from 6 to 12 years old - 1/2 tablet, the maximum daily dose - 2 tablets.
The maximum duration of treatment for children is 3 days.
The maximum duration of treatment for adults is not more than 5 days when prescribed as an anesthetic and not more than 3 days as an antipyretic.
Side effects of
Paracetamol
From the digestive system: rarely - nausea, very rarely - vomiting, diarrhea, epigastric pain, jaundice, pancreatitis and increased activity of liver enzymes.
Allergic reactions: rarely - skin rash, skin itching, urticaria, angioedema.
From the hemopoietic system and the lymphatic system: very rarely - anemia, leukopenia.
Other: weakness.
Ascorbic acid
Allergic reactions: skin rash, flushing of the skin.
Laboratory indicators: thrombocytosis, hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia, glucosuria.
Drug Interactions
While taking other drugs with Paracetamol EXTRATAB, you should consult your doctor.
Paracetamol reduces the effectiveness of uricosuric drugs.
With prolonged and regular use, paracetamol potentiates the effects of warfarin and other coumarin derivatives and increases the risk of bleeding.
Concomitant use of colestyramine leads to a decrease in the absorption of paracetamol (and a weakening of the effects of paracetamol).
Metoclopramide and domperidone increase paracetamol absorption.
The simultaneous use of paracetamol and NSAIDs (including metamizole sodium, acetylsalicylic acid, ibuprofen) increases the risk of developing analgesic nephropathy and renal papillary necrosis, end-stage renal failure.
The simultaneous use of paracetamol and chloramphenicol may be accompanied by an increase in T1 / 2 of chloramphenicol up to 5 times.
Inducers of microsomal liver enzymes (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxication even with small overdoses.
Salicylamide increases T1 / 2 of paracetamol, which leads to the accumulation of paracetamol and, accordingly, increased formation of its toxic metabolites.
The simultaneous use of paracetamol and ethanol can enhance the hepatotoxicity of paracetamol, as well as contribute to the development of acute pancreatitis.
Diflunisal increases the plasma concentration of paracetamol by 50% - the risk of hepatotoxicity.
Other medicines containing paracetamol, as well as other non-narcotic analgesics, should not be used simultaneously. The simultaneous use of other medicines should be agreed with the doctor.
Ascorbic acid increases the blood concentration of benzylpenicillin and tetracyclines at a dose of 1 g / day, increases the bioavailability of ethinyl estradiol (including that which is part of oral contraceptives), improves the absorption of iron preparations in the intestines (converts ferric iron to divalent iron), while increasing iron excretion while use with deferoxamine reduces the effectiveness of heparin and indirect anticoagulants.
Acetylsalicylic acid, oral contraceptives, fresh juices and alkaline drink reduce the absorption and absorption of ascorbic acid. With simultaneous use with acetylsalicylic acid, urinary excretion of ascorbic acid increases and excretion of acetylsalicylic acid decreases.
Acetylsalicylic acid reduces the absorption of ascorbic acid by about 30%.
Ascorbic acid increases the risk of crystalluria in the treatment of short-acting salicylates and sulfanilamides, slows the excretion of acid by the kidneys, increases the excretion of drugs with an alkaline reaction (including alkaloids), and reduces the concentration of oral contraceptives in the blood.
Quinoline drugs, calcium chloride, salicylates, glucocorticosteroids, with prolonged use, deplete the reserves of ascorbic acid.
With the simultaneous use of ascorbic acid reduces the chronotropic effect of isoprenaline.
With long-term or high-dose use, ascorbic acid may interfere with the interaction of disulfiram and ethanol in high doses, increasing the excretion of mexiletine by the kidneys.
Barbiturates and primidone increase urinary excretion of ascorbic acid.
Ascorbic acid reduces the therapeutic effect of antipsychotic drugs (antipsychotics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.
Overdose
Paracetamol
Symptoms: during the first 24 hours after ingestion - pallor of the skin, nausea, vomiting anorexia, abdominal pain impaired glucose metabolism, metabolic acidosis.
Symptoms of liver dysfunction can occur 12-48 hours after overdose. In severe overdose - hepatic failure with progressive encephalopathy, coma, death acute renal failure with turbulent necrosis (including in the absence of severe liver damage) arrhythmia, pancreatitis. Hepatotoxic effect in adults is manifested with intake of 10 g or more. Rarely, liver failure develops rapidly and may be complicated by renal failure (tubular necrosis).
Treatment: administration of SH-group donors and precursors of glutathione - methionine synthesis - within 8-9 h after overdose and acetylcysteine - within 8 h. Need for additional therapeutic measures (further administration of methionine, (in / in the introduction of acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as the time elapsed after administration.
Ascorbic acid
Symptoms: diarrhea, nausea, irritation of the gastrointestinal mucosa, flatulence, abdominal pain of spastic nature, frequent urination, nephrolithiasis, insomnia, irritability, hypoglycemia.
Treatment: symptomatic, forced diuresis.
Storage Conditions
The product should be stored out of reach of children, in a dry, dark place at a temperature not exceeding 25 ° C.
Shelf life
2 years.
Active ingredient
Paracetamol, Ascorbic acid
Terms and conditions
without prescription
dosage form
tablets
Indications
Indications
headache, toothache pain, SARS, Myalgia, Influenza, Fever, Neuralgia
Paracetamol Extratab 500 mg + 150 mg tablets 20 pcs. (Paracetamol, ascorbic acid) florida in pharmacy online. Cheap price, instruction, side effects, dosage. Paracetamol Extratab 500 mg + 150 mg tablets 20 pcs. - Sale. PayPal accept. Free shipping florida. Fast international shipping.
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