Parnaveal Amlo tablets 10 mg + 8 mg 30 pcs. (amlodipine, perindopril)

Pharmacological action of

Perindopril is an inhibitor of the enzyme that converts angiotensin I to angiotensin II (an ACE inhibitor). Angiotensin-converting enzyme, or kininase II, is an exopeptidase, which carries out both the conversion of angiotensin I into a vasoconstrictor substance angiotensin II, and the destruction of bradykinin, which has a vasodilating effect, to an inactive heptapeptide. Since ACE inactivates bradykinin, ACE suppression is accompanied by an increase in the activity of both the circulating and tissue kallikrein-kinin systems, while the prostaglandins system is also activated. Perindopril has a therapeutic effect due to its active metabolite, perindoprilat. Other metabolites do not inhibit ACE.

Amlodipine is a “slow” calcium channel blocker (BMCC), a derivative of dihydropyridine.

Amlodipine inhibits the transmembrane transition of calcium ions to cardiomyocytes and smooth muscle cells of the vascular wall. The antihypertensive effect of amlodipine is due to a direct effect on the smooth muscle cells of the vascular wall. It has been established that amlodipine: • causes the expansion of peripheral arterioles, decreasing the total peripheral vascular resistance (afterload) since heart rate does not change, and myocardial oxygen demand decreases. • causes the expansion of coronary arteries and arterioles in both ischemic and intact zones. In patients with Prinzmetal angina, coronary blood flow improves.

Amlodipine + Perindopril The main criterion for evaluating the effectiveness of prolonged use of amlodipine in combination with perindopril is a combined indicator of the frequency of non-fatal myocardial infarction (including painless) and lethal outcomes of coronary heart disease. The complication rate decreases with the use of amlodipine in combination with perindopril.

Indications

Arterial hypertension and / or coronary heart disease (CHD): stable angina pectoris in patients who require perindopril and amlodipine therapy.

Contraindications

Perindopril

- Hypersensitivity to perindopril or other ACE inhibitors

- History of angioedema (Quincke's edema) (including when taking other ACE inhibitors) srdlcrp - 18 years old efficacy and safety not established).

- The simultaneous use of perindopril and drugs, containing aliskiren in patients with renal failure (CC less than 60 ml / min) and patients with diabetes mellitus.

Amlodipine

- Hypersensitivity to amlodipine or other derivatives of dihydropyridine

- Severe arterial hypotension (systolic blood pressure (BP) less than 90 mmHg)

- Obstruction of the exit tract of the left ventricle (for example, severe stenocardial angina pectoris) (with the exception of Prinzmetal angina)

- Age under 18 years (effectiveness and safety have not been established).

- Shock (including cardiogenic).

- Hemodynamically unstable heart failure after acute myocardial infarction.

Amlodipine + Perindopril

- Hypersensitivity to excipients,

- Renal failure (creatinine clearance (CC) less than 60 ml / min)

- Under 18 years of age (efficacy and safety not established)

- Hereditary lactose intolerance, lactase deficiency and glucose-galactose malabsorption.

Composition

1 tablet 10 mg + 8 mg

Active ingredients: amlodipine besilate - 13.88 mg in terms of amlodipine base -10.0 mg and perindopril erbumin - 8.0 mg

Dosage and administration

Inside, 1 tablet 1 time per day, preferably in the morning before meals. The dose of Parnawel Amlo is selected after a previous titration of doses of the individual components of the drug: perindopril and amlodipine in patients with arterial hypertension and / or coronary heart disease.

With therapeutic need, the dose of Parnawel Amlo may be changed or an individual dose selection of individual components may be preliminarily performed: 4 mg of perindopril + 5 mg of amlodipine or 8 mg of perindopril + 5 mg of amlodipine or 4 mg of perindopril + 10 mg of amlodipine or 8 mg of perindopril + 10 mg of amlodipine. Parnawel Amlo in doses of 4 mg perindopril + 10 mg amlodipine and 8 mg perindopril + 10 mg amlodipine is the maximum daily dose that should not be exceeded.

active substance

Amlodipine, Perindopril



drugstore conditions for prescription



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