Pentalgin tablets, 24 pcs. (Paracetamol, Naproxen, Caffeine, Drotaverin, Fenyramyn)

release form

coated tablets



packaging 24 pcs

Pharmacological action

Combined drug, It has an analgesic, antipyretic and anti-inflammatory effect.

Drotaverine - has a myotropic antispasmodic effect due to the inhibition of phosphodiesterase IV, acts on smooth muscles in the gastrointestinal tract, biliary tract, genitourinary and vascular systems.

Pheniramine is a H1-histamine receptor blocker. It has an antispasmodic and mild sedative effect, reduces the effects of exudation, and also enhances the analgesic effect of paracetamol and naproxen.

Paracetamol is a non-narcotic analgesic that has an antipyretic and analgesic effect due to the blockade of cyclooxygenase in the central nervous system and the effect on the centers of pain and thermoregulation.

Naproxen is a non-steroidal anti-inflammatory drug that has anti-inflammatory, analgesic and antipyretic effect associated with the non-selective suppression of cyclooxygenase activity that regulates the synthesis of prostaglandins.

Caffeine - causes the expansion of blood vessels of skeletal muscles, heart, kidneys, increases mental and physical performance, helps to eliminate fatigue and drowsiness, increases the permeability of histohematological barriers and increases the bioavailability of non-narcotic analgesics, thereby enhancing the therapeutic effect. It has a tonic effect on the vessels of the brain.

Indications

mild to moderate pain syndrome of various origins (including joint pain, muscle pain, sciatica, algodismenorrhea, neuralgia, headache, migraine, toothache)

fever, colds and other diseases accompanied by pain and inflammation.

Contraindications

severe liver failure

severe renal failure

gastric and duodenal ulcer in the acute phase

bronchial asthma

bronchospasm

anemia, anemia, respiratory depression accompanied by

traumatic brain injury

severe arterial hypertension

acute myocardial infarction

arrhythmias

intoxication

glaucoma glucose-6-phosphate dehydrogenase deficiency

sensitivity to children age.

With caution, the drug should be used for mild and moderate arterial hypertension, gastric and / or duodenal ulcer in remission, as well as in elderly patients.

Use during pregnancy and lactation

The use of the drug during pregnancy and during lactation (breastfeeding) is contraindicated.

Composition

1 tablet contains:

paracetamol 325 mg,

naproxen 100 mg,

caffeine drotaverin hydrochloride - 40 mg,

pheniramine maleate - 10 mg

microcrystal srld krcfcrcrd srldcrcfcrcd srllcrd sodium,

hyprolose (hydroxypropyl cellulose (EF klucel)),

citric acid monohydrate,

butylhydroxytoluene (E 321),

magnesium stearate,

talcum,

dye quinoline indium yellow (yellow).

Dosage and administration of

Pentalgin is taken orally 1 tablet 1-3 times a day.

The maximum daily dose is 4 tablets.

Duration of treatment is not more than 3 days as an antipyretic and not more than 5 days as an anesthetic.

Continuation of treatment with the drug is possible only after consulting a doctor.

Side effects

Allergic reactions: skin rash, itching, urticaria, angioedema

edema From the hemopoietic organs: thrombocytopenia, leukopenia, agranulocytosis, anemia, methemoglobinemia

From the nervous system: agitation, anxiety, increased reflexes, tremor, headache, sleep disturbances, dizziness, cardiovascular system attention : palpitations, arrhythmias, increased blood pressure

From the digestive system: erosive and ulcerative lesions of the gastrointestinal tract, nausea, vomiting, discomfort in the epigastrium, pain in urine, constipation, impaired liver function

From the urinary system: impaired renal function

From the sensory organs: hearing loss, tinnitus, increased intraocular pressure in patients with angle-closure glaucoma

Other: dermatitis, tachypnea (rapid breathing).

Drug Interaction

With the simultaneous use of agents that have a depressing effect on the CNS (including sedatives and tranquilizers), it is likely that the severity of the sedative effect and the depressing effect on the respiratory center. Increases the effect of ethanol on the psychomotor response.

Metamizole sodium lowers the concentration of cyclosporine. Metamizole sodium, displacing oral hypoglycemic drugs, indirect anticoagulants, glucocorticosteroids and indomethacin from the protein association, increases their activity.

Tricyclic antidepressants, oral contraceptives, allopurinol interferes with the metabolism of metamizole in the liver and increases its toxicity.

Concomitant use with other non-narcotic analgesics may lead to increased toxic effects.

Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes attenuate the effect of metamizole.

Overdose

Symptoms: nausea, vomiting, gastralgia, drowsiness, tachycardia, heart rhythm disorders, delirium, weakness, respiratory depression.

Treatment: induction of vomiting, gastric lavage through the probe, appointment of adsorbents (activated carbon), symptomatic therapy aimed at maintaining vital functions.

Storage conditions

Store in a dry, dark place at a temperature of no higher than 25 ° C.

Expiration

1 year.

Active ingredient

Paracetamol, Naproxen, Caffeine, Drotaverin, Pheniramine

dosage form

dosage form

tablets

Pharmstandard-Leksredstva, Russia



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