Pentalgin tablets, 4 pcs. (paracetamol, naproxen, caffeine, Drotaverine, Fenyramyn)

release coating coated tablets



packaging 4 pcs

Pharmacological action

Combined preparation, has analgesic, antipyretic and anti-inflammatory effects.

Drotaverine - has a myotropic antispasmodic effect due to the inhibition of phosphodiesterase IV, acts on smooth muscles in the gastrointestinal tract, biliary tract, genitourinary and vascular systems.

Pheniramine is a H1-histamine receptor blocker. It has an antispasmodic and mild sedative effect, reduces the effects of exudation, and also enhances the analgesic effect of paracetamol and naproxen.

Paracetamol is a non-narcotic analgesic, has an antipyretic and analgesic effect, due to the blockade of cyclooxygenase in the central nervous system and the impact on the centers of pain and thermoregulation.

Naproxen is a non-steroidal anti-inflammatory drug that has anti-inflammatory, analgesic and antipyretic effects associated with non-selective suppression of the activity of cyclooxygenase that regulates prostaglandin synthesis.

Caffeine - causes the expansion of blood vessels of skeletal muscles, heart, kidneys, increases mental and physical performance, helps to eliminate fatigue and drowsiness, increases the permeability of histohematological barriers and increases the bioavailability of non-narcotic analgesics, thereby enhancing the therapeutic effect. It has a tonic effect on the vessels of the brain.

Indications

mild to moderate pain syndrome of various origins (including joint pain, muscle pain, radiculitis, algodismenorrhea, neuralgia, headache, migraine, toothache)

fever, colds and other diseases accompanied by pain and inflammation.

Contraindications

severe liver failure

severe renal failure

gastric and duodenal ulcer in the acute phase

bronchial asthma

bronchospasm

anemia leukopenia

conditions accompanied by respiratory depression

traumatic brain injury

severe arterial hypertension

acute myocardial infarction

arrhythmias

intoxication

glaucoma glucose-6-deficient child-specific drug.

With caution, the drug should be used for mild and moderate arterial hypertension, gastric and / or duodenal ulcer in remission, as well as in elderly patients.

Use during pregnancy and lactation

The use of the drug during pregnancy and during lactation (breastfeeding) is contraindicated.

Composition

1 tablet contains:

paracetamol 325 mg,

naproxen 100 mg,

caffeine 50 mg,

drotaverine hydrochloride - 40 mg,

pheniramine maleate - 10 mg

excipients: microcrystalline

microcrystalline cellulose, potato starch

, croscarmellose sodium

, hyprolose

(hydroxypropyl cellulose (EF cluccel), citric acid monohydrate

, srldkl srld, yellow st

indigo carmine (E 132).

Dosage and administration of

Pentalgin is taken orally 1 tablet 1-3 times a day.

The maximum daily dose is 4 tablets.

Duration of treatment is not more than 3 days as an antipyretic and not more than 5 days as an anesthetic.

Continuation of treatment with the drug is possible only after consulting a doctor.

Side effects

Allergic reactions: skin rash, itching, urticaria, angioedema

Hematopoietic organs: thrombocytopenia, leukopenia, agranulocytosis, anemia, nervousness anxiety, nervousness, nervousness, nervousness, nervousness, nervousness, nervousness, nervous system, sleep disturbances, dizziness, decreased concentration

From the cardiovascular system: palpitations, arrhythmias, increased blood pressure

From the digestive system: erosive-ulcerative lesions of the gastrointestinal tract, nausea, vomiting, epigastric discomfort, abdominal pain, constipation, abnormal liver function

From the urinary system: renal dysfunction

From the senses: hearing loss, tinnitus, increased intraocular pressure in patients with angle-closure glaucoma

Other: dermatitis, tachypnea (rapid breathing).

Overdose

Symptoms: nausea, vomiting, gastralgia, drowsiness, tachycardia, heart rhythm disorders, delirium, weakness, respiratory depression.

Treatment: induction of vomiting, gastric lavage through a probe, appointment of adsorbents (activated charcoal), symptomatic therapy aimed at maintaining vital functions.

Storage conditions

Store in a dry, dark place at a temperature not exceeding 25 ° C.

Expiration

1 year.

Active ingredient

Paracetamol, Naproxen, Caffeine, Caffeine taveryn, Fenyramyn

Pharmacy terms

OTC

Dosage form

dosage form

tablets

Pharmstandard-Leksredstva, Russia



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