Penzital tablets, 20 pcs. (Pancreatin)

Enteric form

Enteric coated tablets

Packing

20 pcs.

Pharmacological action

Penzital compensates for the insufficiency of exocrine pancreatic function, has a proteolytic, amylolytic and lipolytic effect.

Pancreatin-containing enzymes (lipase, alpha-amylase, trypsin, chymotrypsin) help break down proteins to amino acids, fats to glycerol and fatty acids, starch to dextrins and monosaccharides.

Penzital improves the functional state of the gastrointestinal tract, normalizes digestion.

Trypsin inhibits the stimulated secretion of the pancreas, providing an analgesic effect.

Pancreatic enzymes are released from the dosage form in the alkaline environment of the small intestine, because protected from the action of gastric juice by the membrane.

Maximum enzymatic activity is noted 30-45 minutes after oral administration.

Indications

Substitution therapy for exocrine pancreatic insufficiency: chronic pancreatitis, pancreatectomy, post-irradiation, dyspepsia, Remkheld’s syndrome (gastrocardial syndrome), cystic fibrosis flatulence, non-infectious diarrhea. Violation of food digestion (the condition after resection of the stomach and small intestine) to improve digestion in people with normal gastrointestinal function in case of eating errors (eating fatty foods, large amounts of food, irregular nutrition), with violations of chewing function, a sedentary lifestyle, and prolonged immobilization. Preparation for x-ray examination and ultrasound of the abdominal organs.

Contraindications

Hypersensitivity to the drug, acute pancreatitis, exacerbation of chronic pancreatitis.

Special instructions

The safety of pancreatin use during pregnancy has not been sufficiently studied. Use is possible in cases where the expected benefit to the mother outweighs the potential risk to the fetus. In case of cystic fibrosis, the use of pancreatin in high doses is not recommended due to an increased risk of developing strictures (fibrotic colonopathy). The dose should be adequate to the amount of enzymes necessary for fat absorption, taking into account the quality and quantity of food consumed. With prolonged use, iron preparations are prescribed at the same time.

Composition

1 tablet contains: Pancreatinum 212.5 mg with enzymatic activity:

lipase 6000 IU FIP

amylase 4500 IU FIP

protease 300 IU FIP

excipients: lactose, microcrystalline cellulose, sodium starch glycolate, polyvinylpyrrolidone, talc, colloidal silicon dioxide, methacrylate diolate.

Dosage and Administration

Inside. Penzital is taken during or after meals without chewing and drinking with non-alkaline liquids (water, fruit juices).

Dose is determined individually depending on the degree of digestive disorders. Adults usually 1-2 tablets 3 times a day.

In children, the drug is used as directed by a doctor. The duration of treatment can vary from a few days (if the digestive process is disturbed due to errors in the diet) to several months or years (if constant replacement therapy is necessary).

Side effects

Allergic reactions. In some cases, diarrhea, constipation, a feeling of discomfort in the stomach, nausea (a causal relationship between the development of these reactions and the action of pancreatin has not been established, because these phenomena relate to symptoms of exocrine pancreatic insufficiency). With prolonged use in high doses, the development of hyperuricosuria, an increase in the level of uric acid in the blood plasma are possible. With cystic fibrosis, if the required dose of pancreatin is exceeded, strictures (fibrotic colonopathy) may develop in the ileocecal section of the ascending colon. When using pancreatin in high doses in children, perianal irritation and irritation of the oral mucosa are possible.

Drug interaction

With the simultaneous use of pancreatin with iron preparations, a decrease in absorption of the latter is possible. The simultaneous use of antacids containing calcium carbonate and / or magnesium hydroxide can lead to a decrease in the effectiveness of pancreatin.

Overdose

Symptoms of hyperuricosuria, hyperuricemia. In children - constipation.

Treatment: drug withdrawal, symptomatic therapy.

Storage conditions

At a temperature not exceeding 25 ° C, in a dry, inaccessible place for children.

Deystvuyuschee substances

Pancreatin

Prescription terms and conditions from

pharmacies Over-the-counter

Form of Treatment

tablets



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