Phlebodia 600 tablets 600 mg, 60 pcs. (diosmin)

packaging

60pcs

Pharmacological action of

The drug Phlebodia 600 has a phlebotonizing effect (reduces venous extensibility, increases venous tone (dose-dependent effect), reduces venous congestion), improves lymphatic drainage (increases the tone and frequency of reduction of lymphatic capillaries, increases their functional density, reduces lymphatic pressure) , improves microcirculation (increases capillary resistance (dose-dependent effect), reduces their permeability), reduces the adhesion of leukocytes to the venous wall and their moment ation in paravenoznye tissue, and improves the diffusion of oxygen into the skin tissue perfusion, clothes the anti-inflammatory action. Enhances the vasoconstrictor effect of adrenaline, norepinephrine, blocks the production of free radicals, the synthesis of prostaglandins and thromboxane.

Pharmacokinetics

Quickly absorbed from the gastrointestinal tract, detected in plasma 2 hours after administration. The maximum plasma concentration is reached 5 hours after administration.

Evenly distributed and accumulated in all layers of the walls of the vena cava and saphenous veins of the lower extremities, to a lesser extent - in the kidneys, liver and lungs and other tissues.

Selective accumulation of diosmin and / or its metabolites in venous vessels reaches a maximum by 9 hours after administration and lasts for 96 hours. It is excreted by the kidneys 79%, intestines - 11%, with bile - 2.4%.

Indications

As part of complex therapy:

elimination of symptoms of lymphatic venous insufficiency of the lower extremities: feeling of heaviness or fatigue in the legs, pain

additional treatment for impaired microcirculation

acute hemorrhoids (symptomatic therapy).

Contraindications

hypersensitivity to the components of the drug Flebodia 600

breastfeeding period

pregnancy (I trimester - experience with use is limited)

childhood (under 18 years).

Pregnancy and lactation

There have been no clinical reports so far.about any side effects when using the drug in pregnant women.

Use during pregnancy in the II and III trimesters is possible only as prescribed by the doctor in cases where the expected benefit to the mother outweighs the potential risk to the fetus.

In experimental studies, no teratogenic effects on the fetus were detected. During breastfeeding, it is not recommended to take the drug, because there is no data on the penetration of the drug into breast milk.

Special instructions

Treatment of an acute attack of hemorrhoids is carried out in combination with other drugs, in the absence of a quick clinical effect, an additional examination and adjustment of the therapy are necessary.

Effect on ability to drive vehicles. There is no data on the negative effect of the drug on the ability to drive vehicles and other mechanisms.

Composition of

1 tablet contains:

Active ingredient:

diosmin (in terms of dry matter) 600 mg

Excipients:

talcum - 10.24 mg

silicon dioxide colloid - 3.5 mg srdl5p 50,0

st mg

MCC - up to 910 mg

film sheath:

Sepifilm 002 (hypromellose (E464) - 9.832 mg,

MCC - 7.866 mg,

macrogol 8 stearate type 1 - 1.967 mg)

Sepispers AR 5523 pink (propylene glycol - traces, hypromellose (E464) - 0.458 mg, titanium dioxide (E171) - 4.026 mg,

dye crimson (E124) - 0.401 mg, black iron oxide (E172) - 0.13 mg, red iron oxide (E172) - 0.02 mg)

Opaglos 6000 (carnauba wax (E903) - 0.075 mg, beeswax (E901) - 0.075 mg, shellac (E904) - 0.15 mg, ethanol 95 ° - traces).

Dosage and administration of

Before using the drug, consult your doctor.

The drug is intended for oral administration.

With varicose veins of the lower extremities and chronic lymphovenous insufficiency (edema, pain, cramps), I tablet is prescribed per day in the morning on an empty stomach.

Duration of therapy is usually 2 months. With exacerbation of hemorrhoids, the drug is prescribed for 2-3 tablets per day with meals for 7 days.

If one or more doses of the drug is missed, it is necessary to continue using the drug in the usual mode and in the usual dose.

Side effects

In rare cases, hypersensitivity to the components of the drug (requiring a break in treatment).

From the gastrointestinal tract: dyspeptic disorders (heartburn, nausea, abdominal pain).

From the side of the central nervous system: headache.

If any of the side effects listed in the description are exacerbated, or the patient has noticed any other side effects not listed in the description, you should inform your doctor.

Drug Interactions

No clinically significant effects of interaction with other drugs have been described.

Conditions of release from drugstores srdlfrew Without a prescription

Dosage form

tablets

Appointment

Adult Prescription, Pregnant doctor prescribing

Indications

Hemorrhoids, Varicosis, Vascular diseases of the eyes, Trophic ulcers

Laboratory Innoter, France



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