Phthalazole tablets 500 mg, 10 pcs. (Phthalylsulfathiazole)
Special Price
$18.70
Regular Price
$22.00
In stock
SKU
newyork494547
Release form
Tablets. Buy Phthalazole tablets 500 mg, 10 pcs. (Phthalylsulfathiazole) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Tablets. Buy Phthalazole tablets 500 mg, 10 pcs. (Phthalylsulfathiazole) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Release form
Tablets.
Packing
10 pcs.
Pharmacological action of
Phthalazole, like other sulfa drugs similar in structure to PABA (para-aminobenzoic acid), by the principle of competitive relationships, it prevents its inclusion in the synthesis of folic acid in microbial cells. This leads to a disruption in the formation of folic acid, which is involved in the synthesis of purine and pyrimidine bases, on which the growth and development of microorganisms depends. Phthalazole exerts the most pronounced bacteriostatic effect on the vegetative forms of microbes. This effect develops gradually, as there are some PABA stores in the microbial cell. In addition, the degree of affinity of Phthalazole with dihydrofolic acid synthetase, an enzyme that limits the formation of folic acid, is much weaker than PABA. Therefore, phthalazole can be administered in sufficiently high doses that interfere with the use of PABA microorganisms contained in tissues. Otherwise, persistent strains of pathogens may form, which are not amenable to further exposure to sulfa drugs. In addition to antibacterial, Phthalazole, like other sulfanilamide drugs, has an anti-inflammatory effect, which is associated with its ability to restrict the migration of leukocytes, reduce the total number of migrating cell elements and partially stimulate the production of glucocorticosteroids.
The spectrum of antimicrobial action of Phthalazole, like other sulfanilomides, is narrower than that of antibiotics. Sulfanilamides have a bacteriostatic effect on: Streptococcus, Pneumococcus, Staphylococcus, Meningococcus, Gonococcus, Escherichia colli, Pseudomonas aeruginosa, Shigella dysenteriae, Proteus vulgaris. And a number of large viruses - pathogens of trachoma and follicular conjunctivitis.
Indications
- Dysentery (acute and chronic in the acute stage).
- Colitis.
- Gastroenteritis.
- Prevention of infectious complications during surgical interventions in the intestine.
Contraindications
- Hypersensitivity (including to other sulfonamides).
- Diseases of the blood system.
- Diffuse toxic goiter.
- Chronic renal failure.
- Glomerulonephritis.
- Acute hepatitis.
- Intestinal obstruction.
Composition of
1 tablet contains: phthalyl sulfathiazole 0.5 g
Excipients: potato starch, calcium stearate, low molecular weight polyvinylpyrrolidone medical, aerosil.
Dosage and administration of
In acute dysentery: for adults, 1 g 6 times / day (1-2 g every 4 hours) for adults, 1 g 4 times / day for 3-4 days ( every 6 hours - 1 g), in 5-6 days - 1 g 3 times / day (every 8 hours - 1 g). The average course dose is 25-30 g. After 5-6 days, the second cycle of treatment is carried out: 1-2 days - 1 g 5 times / day (every 4 hours, at night - after 8 hours), 3-4 days - after 1 g 4 times / day (do not give at night), 5 day - 1 g 3 times / day. The total dose in the second cycle is 21 g, and with a mild course - 18 g. Highest doses for adults: a single dose - 2 g, daily - 7 g. Children under 3 years old - 0.2 g / kg / day in 3 divided doses. for 7 days, children over 3 years of age - 0.4-0.75 g (depending on age) for admission 4 times a day.
Other infections: adults in the first 2-3 days - 1-2 g every 4-6 hours, and in the next 2-3 days - half the dose. Children are prescribed 0.1 g / kg / day in equal doses after 4 hours (with a night break), on the following days, 0.2-0.5 g every 6-8 hours.
Side effects
Allergic reactions are possible with individual hypersensitivity to sulfonamides.
Drug interaction
PASK (paraaminosalicylic acid) and barbiturates - the activity of sulfanilomides is enhanced. Salicylates - increased activity and toxicity. Methotrexate and diphenin - toxicity increases. Thioacetazone, chloramphenicol - the possibility of developing agranulocytosis increases. Nitrofurans - the risk of methemoglobinemia anemia increases. Indirect anticoagulants - the anticoagulant effect is enhanced. Oxacillin - reduces antibiotic activity.
The combined use of phthalazole with acids and acid-reactive preparations, hexamethylenetetramine, an adrenaline solution is impractical, since they are chemically incompatible. With the combined use of phthalazole with preparations containing esters of para-aminobenzoic acid (novocaine, anesthesin, dicain), the antibacterial activity of sulfonamide is inactivated by a competitive mechanism. The effect is enhanced by antibiotics and well-absorbed sulfonamides.
Storage conditions
Store in a dry, dark place.
Expiration
4 years.
Deystvuyuschee substances
Phthalylsulfathiazole
pharmacy terms of sale
Form of Treatment
tablet
Indications
From poisoning, From intestinal infections, Enteritis, From colitis
Possible product names
Phthalazole (MPI) 500mg Tab. X10
Phthalazole 0.5 N10 TABL
Phthalazole tablet 500mg N10 pack b / w
Phthalazole tablets 500 mg, 10 pcs.
biosynthesis, biosynthesis
Phthalazole tablets 500 mg, 10 pcs. (Phthalylsulfathiazole) newyork in pharmacy online. Cheap price, instruction, side effects, dosage. Phthalazole tablets 500 mg, 10 pcs. - Sale. PayPal accept. Free shipping newyork. Fast international shipping.
Tablets.
Packing
10 pcs.
Pharmacological action of
Phthalazole, like other sulfa drugs similar in structure to PABA (para-aminobenzoic acid), by the principle of competitive relationships, it prevents its inclusion in the synthesis of folic acid in microbial cells. This leads to a disruption in the formation of folic acid, which is involved in the synthesis of purine and pyrimidine bases, on which the growth and development of microorganisms depends. Phthalazole exerts the most pronounced bacteriostatic effect on the vegetative forms of microbes. This effect develops gradually, as there are some PABA stores in the microbial cell. In addition, the degree of affinity of Phthalazole with dihydrofolic acid synthetase, an enzyme that limits the formation of folic acid, is much weaker than PABA. Therefore, phthalazole can be administered in sufficiently high doses that interfere with the use of PABA microorganisms contained in tissues. Otherwise, persistent strains of pathogens may form, which are not amenable to further exposure to sulfa drugs. In addition to antibacterial, Phthalazole, like other sulfanilamide drugs, has an anti-inflammatory effect, which is associated with its ability to restrict the migration of leukocytes, reduce the total number of migrating cell elements and partially stimulate the production of glucocorticosteroids.
The spectrum of antimicrobial action of Phthalazole, like other sulfanilomides, is narrower than that of antibiotics. Sulfanilamides have a bacteriostatic effect on: Streptococcus, Pneumococcus, Staphylococcus, Meningococcus, Gonococcus, Escherichia colli, Pseudomonas aeruginosa, Shigella dysenteriae, Proteus vulgaris. And a number of large viruses - pathogens of trachoma and follicular conjunctivitis.
Indications
- Dysentery (acute and chronic in the acute stage).
- Colitis.
- Gastroenteritis.
- Prevention of infectious complications during surgical interventions in the intestine.
Contraindications
- Hypersensitivity (including to other sulfonamides).
- Diseases of the blood system.
- Diffuse toxic goiter.
- Chronic renal failure.
- Glomerulonephritis.
- Acute hepatitis.
- Intestinal obstruction.
Composition of
1 tablet contains: phthalyl sulfathiazole 0.5 g
Excipients: potato starch, calcium stearate, low molecular weight polyvinylpyrrolidone medical, aerosil.
Dosage and administration of
In acute dysentery: for adults, 1 g 6 times / day (1-2 g every 4 hours) for adults, 1 g 4 times / day for 3-4 days ( every 6 hours - 1 g), in 5-6 days - 1 g 3 times / day (every 8 hours - 1 g). The average course dose is 25-30 g. After 5-6 days, the second cycle of treatment is carried out: 1-2 days - 1 g 5 times / day (every 4 hours, at night - after 8 hours), 3-4 days - after 1 g 4 times / day (do not give at night), 5 day - 1 g 3 times / day. The total dose in the second cycle is 21 g, and with a mild course - 18 g. Highest doses for adults: a single dose - 2 g, daily - 7 g. Children under 3 years old - 0.2 g / kg / day in 3 divided doses. for 7 days, children over 3 years of age - 0.4-0.75 g (depending on age) for admission 4 times a day.
Other infections: adults in the first 2-3 days - 1-2 g every 4-6 hours, and in the next 2-3 days - half the dose. Children are prescribed 0.1 g / kg / day in equal doses after 4 hours (with a night break), on the following days, 0.2-0.5 g every 6-8 hours.
Side effects
Allergic reactions are possible with individual hypersensitivity to sulfonamides.
Drug interaction
PASK (paraaminosalicylic acid) and barbiturates - the activity of sulfanilomides is enhanced. Salicylates - increased activity and toxicity. Methotrexate and diphenin - toxicity increases. Thioacetazone, chloramphenicol - the possibility of developing agranulocytosis increases. Nitrofurans - the risk of methemoglobinemia anemia increases. Indirect anticoagulants - the anticoagulant effect is enhanced. Oxacillin - reduces antibiotic activity.
The combined use of phthalazole with acids and acid-reactive preparations, hexamethylenetetramine, an adrenaline solution is impractical, since they are chemically incompatible. With the combined use of phthalazole with preparations containing esters of para-aminobenzoic acid (novocaine, anesthesin, dicain), the antibacterial activity of sulfonamide is inactivated by a competitive mechanism. The effect is enhanced by antibiotics and well-absorbed sulfonamides.
Storage conditions
Store in a dry, dark place.
Expiration
4 years.
Deystvuyuschee substances
Phthalylsulfathiazole
pharmacy terms of sale
Form of Treatment
tablet
Indications
From poisoning, From intestinal infections, Enteritis, From colitis
Possible product names
Phthalazole (MPI) 500mg Tab. X10
Phthalazole 0.5 N10 TABL
Phthalazole tablet 500mg N10 pack b / w
Phthalazole tablets 500 mg, 10 pcs.
biosynthesis, biosynthesis
Phthalazole tablets 500 mg, 10 pcs. (Phthalylsulfathiazole) newyork in pharmacy online. Cheap price, instruction, side effects, dosage. Phthalazole tablets 500 mg, 10 pcs. - Sale. PayPal accept. Free shipping newyork. Fast international shipping.
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