Phthalazole tablets 500 mg, 10 pcs. (Phthalylsulfathiazole)

Release form

Tablets.

Packing

10 pcs.

Pharmacological action

Phthalazole - an antimicrobial agent from the group of sulfonamides. It has a wide range of actions, including pathogens of intestinal infections. It acts mainly in the intestinal lumen. The mechanism of action is associated with competitive antagonism with PABA and competitive inhibition of dihydropteroate synthetase, disrupts the formation of tetrahydrofoleic acid, necessary for the synthesis of purines and pyrimidines.

Indications

Dysentery, colitis, gastroenteritis, bowel surgery (to prevent purulent complications).

Contraindications

Increased individual sensitivity to diffuse systemic drugs, sulfa toxic acute hepatitis intestinal obstruction

Dosage and administration

Inside, in case of acute dysentery, adults in 1-2 days - 1 g 6 times a day, in 3-4 days - 1 g 4 times a day, in 5-6 days - 1 g 3 times a day. The average course dose is 25-30 g. After 5-6 days, the second course of treatment is carried out: 1-2 days - 1 g 5 times a day (in the afternoon - every 4 hours, at night - after 8 hours), 3-4 days - 1 g 4 times a day (do not give at night), 5 day - 1 g 3 times a day. The total dose in the second cycle is 21 g, with mild course - 18 g.

Highest doses for adults: single - 2 g, daily - 7 g.

Children under 3 years old - 0.2 g / kg in 3 divided doses for 7 days, older than 3 years - 0.4-0.75 g 4 times a day.

For other infections, adults are prescribed 1-2 g every 4-6 hours in the first 2–3 days, half doses for children in the next 2–3 days — 0.1 g / kg / day in equal doses after 4 hours with a night break, the following days - 0.2-0.5 g every 6-8 hours.

Treatment with phthalazole, if necessary, is combined with the appointment of antibiotics. It is also advisable to prescribe along with phthalazole the well-absorbable sulfanides

Side effects

Allergic reactions (rash, fever), deficiency of B vitamins (due to inhibition of intestinal microflora), agranulocytosis, aplasmild anemia.

Drug Interactions

The following interactions may be observed with phthalazole in combination with other drugs.

PASK and barbiturates: increased activity of sulfonamides.

Thioacetasone, chloramphenicol: the possibility of developing agranulocytosis increases.

Nitrofurans: increased risk of anemia and methemoglobinemia.

Indirect anticoagulants: the anticoagulant effect is enhanced.

Oxacillin: decreased antibiotic activity.

The combined use of phthalazole with acids and acid-reactive drugs, hexamethylenetetramine, an adrenaline solution is impractical, because they are chemically incompatible.

With the combined use of phthalazole with preparations containing PABA esters (novocaine, anestezin, dicaine), the antibacterial activity of sulfanilamide is inactivated by a competitive mechanism. The effect is enhanced by antibiotics and well-absorbed sulfonamides.

Storage conditions

In a dry, dark place, at temperatures up to 25 ° C.

active substance

ftalilsulfatiazol

The dosage form of

tablet

Prescribing

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Indications

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