Pimafucin cream 2%, 30 g (Natamycin)

Latin name

Pimafucin

Release form

Cream for external use.

Pharmacological action

Pimafucin - fungicidal, antifungal.

Pharmacodynamics

Natamycin irreversibly binds to the sterols of the cell membranes of fungi, disrupting the integrity and function, which leads to the death of microorganisms.

Most pathogenic yeasts, especially Candida albicans, are sensitive to natamycin. Dermatophytes are less sensitive to natamycin. Primary resistance to natamycin is not found in clinical practice.

Pharmacokinetics

Natamycin has only local action, not absorbed from the digestive tract, through the skin and mucous membranes.

Indications

fungal diseases of the skin and mucous membranes caused by pathogens sensitive to the drug, including: vulvitis, vulvovaginitis, balanoposthitis, caused mainly by Candida

fungi candidiasis of the skin and nails

external otitis media, or primarily caused candidiasis

dermatomycosis.

Contraindications

Hypersensitivity to the components of the drug.

Ingredients

1 g cream contains:

Active ingredient: natamycin 20 mg

Excipients: decyl oleate - 100 mg - 100 mg 50 mg cetostearyl alcohol - 135 mg sodium lauryl sulfate - 15 mg methyl parahydroxybenzoate - 2 mg propyl parahydroxybenzoate - 1 mg propylene glycol - 150 mg purified water.

Dosage and administration

cream, topically. With vulvitis, vulvovaginitis, balanoposthitis, the cream is applied to the affected areas 1 or several times a day. In the persistent course of vulvitis, vulvovaginitis caused by Candida albicans, Pimafucin® is additionally prescribed in the form of tablets inside or vaginal suppositories.

With dermatomycosis (including candidiasis of the skin and nails, diaper rash in children) the cream is applied to the affected surface of the skin and nails one or more (up to 4) once a day.

With mycosis of the external auditory canal, the affected surface is smeared with cream one or several (up to 4) times a day. Before using the drug, the ear is cleaned. After using the drug, turunda from natural material (cotton, wool) is placed in the ear canal.

The duration of treatment is set individually. After the symptoms disappear, it is recommended to continue treatment for a few more days.

Side effects of the

From the gastrointestinal tract: in some cases when using enteric tablets, especially in the first days of treatment, nausea and diarrhea are possible, usually passing on their own.

Local reactions: possible slight irritation, burning sensation (when applying cream, vaginal suppositories).

Storage conditions

At a temperature not exceeding 25 ° C.

Expiration

2 years.

Active ingredient

Natamycin

dosage form

cream

Temmler Italy S.R.L., The Netherlands



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