Pipolfen solution for intravenous and intramuscular injection 25mg / ml 2 ml amp 10 pcs. (promethazine)

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Release form

Solution for intravenous and intramuscular administration. Buy Pipolfen solution for intravenous and intramuscular injection 25mg / ml 2 ml amp 10 pcs. (promethazine) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Release form

Solution for intravenous and intramuscular administration.

Packing

10 ampoules of 2 ml

Indications

- allergic diseases (including urticaria, serum sickness, hay fever, allergic rhinitis, allergic conjunctivitis, angioedema, pruritus)

- adjuvant therapy of anaphylactic reactions (after stopping acute manifestations by other means, for example, epinephrine / adrenaline /)

- as a sedative in the pre- and postoperative period

- to prevent or stop nausea and vomiting associated with anesthesia and / or appearing in the postoperative period

- postoperative pain (in combination with analgesics)

- kinetosis (for the prevention and elimination of dizziness and nausea during travel on transport)

- as a component cient lytic mixtures used to potentiate anesthesia in surgical practice (for parenteral use).

Contraindications

- coma or other forms of deep CNS depression

- simultaneous use of MAO inhibitors and a period of 14 days after completion of their intake

- angle-closure glaucoma

- alcohol intoxication, acute intoxication with sleeping pills opioid analgesics

- sleep apnea syndrome

- occasional vomiting in children of unspecified origin

- pregnancy

- lactation period

- children under 2 months of age (for parenteral administration)

- children under 6 years of age (for oral administration) srd hypersensitivity to promethazine, other phenothiazine derivatives and any other component of Pipolfen.

With caution, the drug should be prescribed for acute and chronic respiratory diseases (due to suppression of the cough reflex), open-angle glaucoma, inhibition of bone marrow function, diseases of the cardiovascular system, impaired liver and kidney function, peptic ulcer with pyloroduodenal obstruction, stenosis of the neck of the urinary tract bladder and / or hypertrophy of the prostate gland, predispositions for urinary retention, epilepsy, Reye's syndrome, as well as elderly patients.

Special instructions

With prolonged use of the drug, it is necessary to systematically monitor the peripheral blood formula and liver function.

With extreme caution, especially at high doses, Pipolfen® should be prescribed to elderly patients, as in this category of patients, the risk of side effects is increased.

With concomitant use with Pipolfen, analgesics and sleeping pills should be prescribed in smaller doses.

Pipolfen® should be used under strict medical supervision at the same time as opioid analgesics, sedatives and hypnotics, anesthetics, tricyclic antidepressants and tranquilizers.

Pipolfen® may mask the ototoxic effect (tinnitus and dizziness) of shared medications.

Pipolfen® lowers the seizure threshold. This should be considered when prescribing the drug to patients prone to developing seizures, or simultaneously with other drugs with a similar effect.

As an antiemetic drug, Pipolfen® should be used only with prolonged vomiting of known etiology.

With prolonged use, the risk of developing dental diseases (caries, periodontitis, candidiasis) increases due to a decrease in salivation.

During the treatment period, alcohol is prohibited.

During the course of taking Pipolfen, a diagnostic pregnancy test can give a false positive result.

Consideration should be given to a possible increase in blood glucose in patients taking Pipolfen® when performing a glucose tolerance test.

To prevent distortion of the results of skin scarification tests for allergens, the drug must be canceled 72 hours before allergological tests.

Each tablet contains 95 mg of lactose, which should be considered for lactose intolerance.

Pediatric use

Pipolfen® should be prescribed with caution to children, as this makes it difficult to diagnose the underlying disease. Symptoms of undiagnosed encephalopathy and Reye syndrome may be mistaken for side effects of Pipolfen.

Influence on the ability to drive vehicles and control mechanisms

In the initial period of using Pipolfen, it is necessary to refrain from driving vehicles and engaging in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions. In the future, the degree of restriction is determined depending on the individual tolerance of the patient.

Composition

1 ml: - promethazine hydrochloride 25 mg

Excipients: hydroquinone, potassium disulfite, sodium sulfite anhydrous, sodium chloride, water d / i.

Side effects

From the side of the central nervous system: sedation, drowsiness, nightmares, increased nightly apnea, visual impairment, anxiety, psychomotor agitation, dizziness, confusion, disorientation after administration in high doses - extrapyramidal disorders, increased convulsive activity ( children).

From the cardiovascular system: possibly a decrease in blood pressure, tachycardia, bradycardia.

From the digestive system: nausea, vomiting, constipation, dry mouth, nose, pharynx, anesthesia of the oral mucosa, cholestasis are possible.

From the hemopoietic system: rarely - thrombocytopenia and / or leukopenia, agranulocytosis.

Dermatological reactions: skin rash and / or photosensitivity are possible.

On the part of the sensory organs: noise or ringing in the ears, paresis of accommodation, impaired vision.

Allergic reactions: urticaria, dermatitis, photosensitivity, bronchospasm.

Other: increased sweating, difficulty or painful urination.

Drug interaction

Pipolfen® enhances the effects of opioid analgesics, hypnotics, anxiolytic (tranquilizers) and antipsychotics (antipsychotics), as well as drugs for general anesthesia, local anesthetics, m-anticholinergics and antihypertensive drugs (dose adjustment is required).

Pipolfen® weakens the effects of amphetamine derivatives, m-cholinomimetics, anticholinesterase drugs, ephedrine, guanethidine, levodopa, dopamine.

Barbiturates accelerate elimination and decrease promethazine activity.

Beta-blockers increase (mutually) the concentration of promethazine in blood plasma.

Pipolfen® weakens the action of bromocriptine and increases the concentration of prolactin in the blood serum.

Tricyclic antidepressants and anticholinergic drugs enhance the m-anticholinergic activity of promethazine.

Ethanol, clonidine, antiepileptic drugs increase the inhibitory effect of promethazine on the central nervous system.

MAO inhibitors (simultaneous administration is not recommended) and phenothiazine derivatives increase the risk of arterial hypotension and extrapyramidal disorders. Quinidine increases the likelihood of cardiodepressive action of promethazine.

Overdose

Symptoms: in children - agitation, anxiety, hallucinations, convulsions, mydriasis and immobility of the pupils, facial skin hyperemia, hyperthermia in adults - psychomotor agitation, convulsions, lethargy. In acute overdose - a marked decrease in blood pressure, vascular collapse, respiratory depression, coma.

Treatment: in the absence of antidotes, symptomatic and supportive therapy is performed. Gastric lavage, the appointment of activated charcoal inside (when detoxing early after oral administration) according to indications - antiepileptic drugs. Dialysis is ineffective. The ingestion of sodium or magnesium sulfate can have a beneficial effect.

Measures should be taken to restore adequate pulmonary ventilation by ensuring airway obstruction and assisted or mechanical ventilation. Correction of acidosis and / or electrolyte balance is necessary. In severe arterial hypotension, norepinephrine (norepinephrine) or mesatone should be administered. Epinephrine (epinephrine) paradoxically can enhance arterial hypotension.

Storage Conditions

List B. The drug should be stored in a dark place, out of reach of children at temperatures between 15 ° and 25 ° C.

Expiration

5 years.

active substance

Promethazine

Dosage form

solution for injection and infusion zyy

Prescribed

For children prescribed by a doctor, Adults prescribed by a doctor

Indications

Indications

Allergy, Urticaria, Pollinosis, Quincke's edema, Allergic rhinitis



Pipolfen solution for intravenous and intramuscular injection 25mg / ml 2 ml amp 10 pcs. (promethazine) florida in pharmacy online. Cheap price, instruction, side effects, dosage. Pipolfen solution for intravenous and intramuscular injection 25mg / ml 2 ml amp 10 pcs. - Sale. PayPal accept. Free shipping florida. Fast international shipping.

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