Piracetam solution for iv. and w / mouse. enter 200 mg / ml ampoules 5 ml 10 pcs. (Piracetam)

Release form

Injection

Packing

10 ampoules of 5 ml.

Pharmacological action

Piracetam activates associative processes in the central nervous system, improves mood, memory and mentality in sick and healthy people. Stimulates intellectual activity and integrative activity of the brain, facilitates learning processes, improves communication between the cerebral hemispheres and synaptic conduction in the cortex, increases mental performance, stabilizes and restores impaired brain functions (memory, consciousness, speech). Piracetam normalizes the ratio of ADP to ATP (inhibits nucleotide phosphatase and activates adenylate cyclase), increases the activity of phospholipase A, stimulates bioenergetic and plastic processes in the nervous tissue, and accelerates the exchange of neurotransmitters.

Piracetam increases the resistance of brain tissue to toxic effects and hypoxia, enhances the synthesis of phospholipids and nuclear RNA, enhances glycolytic processes and utilization of glucose in the brain. Piracetam blocks platelet aggregation, improves microcirculation, optimizes the ability of red blood cells to pass through microvessels and the conformational properties of the membrane of red blood cells, in ischemic areas of the brain increases regional blood flow. Piracetam enhances EEG beta and alpha activity and lowers delta activity. Reduces vestibular nystagmus. During hypoxia, intoxication, trauma, electroconvulsive effects, it has a neuroprotective effect.

Due to the antihypoxic effect, piracetam is effective in the complex treatment of myocardial infarction. Anxiolytic and sedative effects in piracetam are absent.

Piracetam is almost completely and rapidly absorbed after oral administration. Bioavailability is 100%. When ingested 2 g of the drug, the maximum plasma concentration is 40-60 mcg / ml after 30 minutes. Piracetam does not bind to plasma proteins. After 2-8 hours, the maximum concentration in the cerebrospinal fluid is created. Piracetam penetrates into all tissues and organs, penetrates through the placental barrier. Almost not metabolized. It selectively accumulates in the cerebral cortex, mainly in the parietal, frontal and occipital lobes, basal ganglia and cerebellum. The half-life of piracetam from plasma is 4–5 hours from the cerebrospinal fluid is 6–8 hours. More than 95% of the drug is excreted unchanged by the kidneys after 30 hours. In patients with renal failure, the elimination half-life increases.

Indications

Chronic cerebrovascular insufficiency (hypertension, atherosclerosis, vascular parkinsonism), which is accompanied by impaired attention, memory, speech, headache and dizziness

ischemic stroke and its consequences

psychoorganism dementia, sr )

head injury

acute viral neuroinfection

intoxication (recovery period, coma and subcomatose state)

more the nervous system, which is accompanied by a decrease in the level of wakefulness, intellectual and mnestic functions, impaired behavior and emotional-volitional sphere

dizziness

vestibular nystagmus

sluggish apathic state

aphasia

cortical myoclonia

epilepsy (as an adjuvant)

senile and atrophic depressive conditions , mental complications of treatment with antipsychotics and other psychotropic drugs

neurotic depression with a predominance in clinical a picture of senesto-hypochondriacal and asthenic disorders, adynamia, phenomena of ideomotor inhibition

psycho-organic syndrome in chronic alcoholism

relief of pre - and delirious, withdrawal symptoms in addiction and alcoholism

acute intoxication with morphine, ethanol, amphetamine,

barbiturates in children - cerebral palsy, consequences of perinatal damage to the central nervous system, mental retardation, poor learning ability in psycho-organic syndrome, speech disorder, oligophrenia, memory impairment, , intellectual insufficiency

sickle cell anemia (as part of complex treatment).

Contraindications

Hypersensitivity (including pyrrolidone derivatives), severe renal failure (with creatinine clearance less than 20 ml / min), hemorrhagic stroke, Huntington's disease, agitated depression, breast-feeding, pregnancy, age up to 1 year.

Use during pregnancy and lactation

Piracetam is contraindicated during pregnancy. During therapy with piracetam, it is necessary to stop breastfeeding, since the drug passes into breast milk.

Special instructions

Use with caution in patients with cerebrovascular accidents, with aortic and / or mitral stenosis in patients prone to orthostatic hypotension in elderly patients

In case of sleep disturbances, it is recommended to cancel the evening intake of piracetam by adding this dose to the daily intake.

Composition

Active ingredient: piracetam - 200.0 g

Excipients: sodium acetate - 1 g, diluted acetic acid - up to pH 5.0-5.8, water for injection - up to 1 liter.

Dosage and administration of

The drug is prescribed intramuscularly or intravenously.

Use of piracetam in adults:

In the treatment of cerebrovascular disorders in the acute phase, the drug should be prescribed as soon as possible, at a dose of 12 g per day for 2 weeks, and then 4.8-6 g per day.

With cortical myoclonia, treatment is started with a dose of 7.2 g per day, every 3-4 days the dose is increased by 4.8 g per day until a maximum dose of 24 g per day is reached 2-3 times a day, by mouth or parenterally. Every 6 months, the dose should be reduced by 1.2 g every 2 days.

For sickle cell anemia, the daily dose is 160 mg / kg, divided into 4 equal portions. During the crisis - up to 300 mg / kg.

With alcoholism - 12 g per day during the manifestation of ethanol withdrawal syndrome, the maintenance dose is 2.4 g.

In the treatment of coma, in the post-traumatic period, the initial dose is 9-12 g per day, supporting - 2.4 g, the course of treatment is 3 weeks.

Drug interactions

Piracetam enhances the effects of indirect anticoagulants, psychostimulants, central effects of thyroid hormones (anxiety, tremor, sleep disturbance, irritability, confusion). The severity of extrapyramidal disorders increases with the combined use of piracetam with antipsychotics.

overdose

Side effects are increased with piracetam overdose.

Treatment: gastric lavage, activated charcoal intake, no symptomatic treatment for a specific antidote, hemodialysis possible (50-60% efficacy).

Storage Conditions

In a dry, dark place. Keep out of the reach and sight of children.

Shelf life

3 years

Active ingredient

piracetam

otpuska IZ

pharmacy prescription

Dosage form

solution for injection and infusion

Dalkhimpharm, Russia



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