Piroxicam capsules 20 mg, 20 pcs. (piroxicam)

Release form

Capsules.

Packing

20 pcs.

Pharmacological action

Piroxicam - analgesic, antipyretic, anti-inflammatory.

Selectively inhibits cyclooxygenase, disrupts the metabolism of arachidonic acid, reduces the formation of PG.

Relieves or eliminates pain of moderate intensity, reduces the severity of inflammation, with articular syndrome reduces morning stiffness of joints, helps to increase range of motion. The full therapeutic effect appears after 10-14 days of use.

Indications

Rheumatoid arthritis, osteoarthritis, spondylitis, acute attack of gout, inflammatory diseases of the musculoskeletal system.

Contraindications

Hypersensitivity, including to NSAIDs, peptic ulcer, hematopoiesis, liver and kidney diseases, cardiovascular failure, bronchial asthma, pregnancy, breast-feeding (breast-feeding should be stopped).

Special instructions

Pyroxicam should be prescribed by doctors who are experienced in the diagnosis and treatment of inflammatory and degenerative joint diseases.

Concomitant use with misoprostol, proton pump inhibitors, H2-histamine receptor blockers reduces gastrointestinal toxicity.

NSAIDs, including piroxicam, can cause severe side effects from the gastrointestinal tract, including bleeding, ulceration and perforation of the stomach, small and large intestines (including fatal ones). These phenomena can occur at any time of treatment and not even be accompanied by threatening symptoms. The risk of these phenomena is especially high for piroxicam increases in the elderly.

Taking piroxicam significantly increases the risk of severe skin reactions (exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis), especially in the early stages of treatment. When the first signs of a rash, ulceration of the mucous membranes or other signs of hypersensitivity occur, piroxicam is immediately canceled.

Piroxicam, like other NSAIDs, increases the risk of thrombotic complications (including myocardial infarction and stroke), patients with risk factors are prescribed these drugs with caution.

Piroxicam, like other NSAIDs, can contribute to the occurrence of arterial hypertension or worsen its course.

In women, the contraceptive effect of IUDs may be reduced due to the effect of piroxicam on myometrial tone.

Ethanol use should be excluded during treatment.

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.

https://www.piluli.ru/product461848/product_info.html Composition

Active ingredient: pyroxecam 20 mg.

Dosage and administration

Inside, 20–40 mg per day in 1–2 doses.

Side effects

Erosive and ulcerative lesions of the digestive tract, swelling, headache, dizziness, drowsiness, allergic skin reactions.

Drug interaction

Enhances the effect of oral anticoagulants, increases the concentration of lithium salts in the blood. Alcohol increases the likelihood of side effects. Derivatives of salicylic acid lower blood levels.

Overdose

Symptoms: nausea, vomiting, abdominal pain, drowsiness, lethargy, gastrointestinal bleeding, increased blood pressure, acute renal failure, respiratory depression, coma.

Treatment: symptomatic. There is no specific antidote. In case of a recent overdose, it is necessary to induce vomiting, take osmotic laxatives, activated carbon (60-100 g for adults, children - 1-2 g / kg). Repeated use of activated carbon (6 hours after administration) reduces T1 / 2 of piroxicam by 50% and its bioavailability by 37%.

Forced diuresis, alkalization of urine, hemodialysis and hemoperfusion are ineffective (high binding to plasma proteins).

Storage Conditions

In a dark place, at a temperature of 15-25 ° C.

Expiration

5 years.

active substance

Piroxicam

Terms leave through pharmacies

In retseptu

Dosage form

capsule



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