Protafan HM penfill cartridges 100 IU / ml, 3 ml, 5 pcs. (Insulin-yzofan chelovecheskyy genetically Inzhenernyi)

Release form

suspension for subcutaneous administration

Packaging

5 cartridges of 3 ml.

Pharmacological action

Hypoglycemic. Protafan HM interacts with a specific plasma membrane receptor and penetrates the cell, where it activates the phosphorylation of cellular proteins, stimulates glycogen synthetase, pyruvate dehydrogenase, hexokinase, and inhibits adipose tissue lipase and lipoprotein lipase. In combination with a specific receptor, it facilitates the penetration of glucose into cells, enhances its uptake by tissues and promotes conversion to glycogen. Increases muscle glycogen supply, stimulates peptide synthesis.

Indications

Type I diabetes mellitus, type II diabetes mellitus (with resistance to sulfonylurea derivatives, intercurrent diseases, operations and in the postoperative period, during pregnancy).

Contraindications

Hypoglycemia, insulinoma.

Composition of

active substance: dextrose monohydrate 5 g metacresol phenol sodium hydrogen phosphate protamine dihydrate sodium sulfate hydroxide and / or hydrochloric acid (for adjusting pH) water for injection

Dosage and administration

Subcutaneously. The drug is intended for subcutaneous administration. Suspensions of insulin cannot be administered iv.

The dose of the drug is selected individually, taking into account the needs of the patient. Typically, insulin requirements are between 0.3 and 1 IU / kg / day. The daily requirement for insulin may be higher in patients with insulin resistance (for example, during puberty, as well as in patients with obesity), and lower in patients with residual endogenous insulin production.

ProtafanВ® NM can be used both in monotherapy and in combination with quick or short acting insulin.

ProtafanВ® HM is usually administered subcutaneously in the thigh. If this is convenient, then injections can also be done in the anterior abdominal wall, in the gluteal region or in the region of the deltoid muscle of the shoulder. With the introduction of the drug into the thigh area, slower absorption is noted than with the introduction to other areas. If the injection is made into an extended skin fold, the risk of accidental intramuscular administration of the drug is minimized.

The needle should remain under the skin for at least 6 seconds, which guarantees a full dose. It is necessary to constantly change the injection site within the anatomical region to prevent the development of lipodystrophy.

ProtafanВ® NM PenfillВ® is designed for use with Novo Nordisk insulin injection systems and NovoFineВ® or NovoTvistВ® needles. Detailed recommendations for the use and administration of the drug should be observed.

Dose adjustment

Concomitant diseases, especially infectious and accompanied by fever, usually increase the body's need for insulin. Dose adjustment may also be required if the patient has concomitant diseases of the kidneys, liver, impaired adrenal function, pituitary gland or thyroid gland. The need for dose adjustment can also arise when changing physical activity or the patient's usual diet. Dose adjustment may be required when transferring a patient from one type of insulin to another

Side effects

Hypoglycemic conditions, allergic reactions, lipodystrophy (with prolonged use).

Drug interaction

Acetylsalicylic acid, alcohol, alpha and beta adrenoblockers, amphetamine, anabolic steroids, clofibrate, cyclophosphamide, fenflufamide, chloroformide, iniforfamide, iniforfetfidamide, tiflorfamide, inhibit trifamide, inhibit trifamide, inhibit trifonamide, enhance the hypoglycemic effect diazoxide, diuretics (especially thiazides), glucocorticoids, heparin, hormonal contraceptives, isoniazid, lithium carbonate, nicotinic acid, phenothiazines, sympathomimetics, tricyclic e antidepressants.

Overdose

Symptoms: development of hypoglycemia (cold sweat, palpitations, tremors, hunger, agitation, irritability, pallor, headache, drowsiness, lack of confidence in movements, impaired speech and vision, depression). Severe hypoglycemia can lead to temporary or permanent impairment of brain function, coma, and death.

Treatment: sugar or glucose solution inside (if the patient is conscious), s / c, i / m or iv - glucagon or iv - glucose.

Storage conditions

In a dark place at a temperature of 2-8 ° C (do not freeze). Store the vial used at room temperature not higher than 30 ° C for 6 weeks. Protect from heat and sunlight.

Deystvuyuschee substances

Insulin-yzofan chelovecheskyy genetically Inzhenernyi

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Protafan HM penfill cartridges 100 IU / ml, 3 ml, 5 pcs. (Insulin-yzofan chelovecheskyy genetically Inzhenernyi) newyork in pharmacy online. Cheap price, instruction, side effects, dosage. Protafan HM penfill cartridges 100 IU / ml, 3 ml, 5 pcs. - Sale. PayPal accept. Free shipping newyork. Fast international shipping.