Riboxin ampoules 2% 10 ml 10 pcs (Ynozyn)

Release form

Solution for injection

Packing

10 ampoules of 10 ml.

Pharmacological action

Riboxin - a derivative (nucleoside) of purine - a precursor of ATP adenosine phosphate. Refers to a group of drugs that stimulate metabolic processes. It has antihypoxic and antiarrhythmic effects. Increases the energy balance of the myocardium, improves coronary circulation, prevents the effects of intraoperative renal ischemia. It is directly involved in the metabolism of glucose and contributes to the activation of metabolism in conditions of hypoxia and in the absence of ATP.

Activates the metabolism of pyruvic acid to ensure the normal process of tissue respiration, and also promotes the activation of xanthine dehydrogenase. Stimulates the synthesis of nucleotides, enhances the activity of certain enzymes of the Krebs cycle. Penetrating into the cells, it has a positive effect on metabolic processes in the myocardium - it increases the force of contractions of the heart and contributes to a more complete relaxation of the myocardium in the diastole, as a result of which the stroke volume increases. The mechanism of antiarrhythmic action is not completely clear.

Reduces platelet aggregation, activates tissue regeneration (especially the myocardium and gastrointestinal mucosa).

Pharmacokinetics

Metabolized in the liver with the formation of glucuronic acid and its subsequent oxidation. A small amount is excreted in the urine.

Indications

Comprehensive treatment of myocardial infarction, coronary heart disease, heart rhythm disturbances caused by the use of cardiac glycosides, against the background of myocardial dystrophy after infectious diseases. Liver diseases (hepatitis, cirrhosis, fatty degeneration). Surgery on an isolated kidney (as a means of pharmacological protection when turning off blood circulation).

Contraindications

Hypersensitivity to the drug, gout, hyperuricemia, pregnancy, lactation, age up to 18 years (efficacy and safety have not been established). Use with caution in renal failure.

Special instructions

During treatment with Riboxin, the concentration of uric acid in the blood and urine should be monitored.

Information for patients with diabetes mellitus: 1 tablet of the drug corresponds to 0.00641 bread units.

Does not affect the ability to drive vehicles and control mechanisms that require increased concentration of attention.

Composition

Active ingredient: inosine (riboxin) 20 mg

Excipients: propylene glycol, sodium hydroxide, sodium sulfite anhydrous, water for injection

Method approx

Side effects

Allergic reactions: pruritus, skin hyperemia (the drug should be discontinued). Rarely: increased concentration of uric acid in the blood, exacerbation of gout (with prolonged use).

Drug Interactions

Immunosuppressants (azathioprine, antilympholine, cyclosporine, thymodepressin, etc.) while using, reduce the effectiveness of Riboxin.

Overdose

No overdose has been reported at this time.

Storage Conditions

In a dry, dark place at a temperature not exceeding 25 ° C. Keep out of the reach and sight of children.

Shelf life

2 years. Do not use after the expiration date indicated on the package.

dosage form

infusion solution

Possible product names

Riboxin ampoules 2% 10 ml 10 pcs



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