Rinzasip for children powder for solution for oral administration Raspberry 3 g sachets 10 pcs. (Paracetamol, phenylephrine, ascorbic acid)

Latin name

Rinzasip

Release form

Rinzasip. The powder for the preparation of a solution for oral administration is granular, from light pink to pink, with white and dark pink spots.

Packaging

3 g - sachets (10) - packs of cardboard.

Pharmacological action

Rinzasip is a combined drug used for colds.

Paracetamol - an analgesic-antipyretic, reduces the pain syndrome observed with colds - sore throat, headache, muscle and joint pain, reduces high body temperature.

Pheniramine - a blocker of histamine H1 receptors, It has an anti-allergic effect: it eliminates itching (including the eyes, nose), swelling and hyperemia of the mucous membranes of the nasal cavity, nasopharynx and sinuses, and reduces the effects of exudation.

Ascorbic acid is involved in the regulation of redox processes, carbohydrate metabolism, blood coagulation, tissue regeneration, in the synthesis of steroid hormones, reduces vascular permeability, reduces the need for vitamins B1, B2, A, E, folic acid, pantothenic acid. Improves the tolerance of paracetamol and lengthens its effect (associated with an extension of T1 / 2).

Indications

ARVI (symptomatic therapy)

allergic rhinitis

rhinopharyngitis

pain syndrome (mild to moderate): arthralgia, myalgia, neuralgia, migraine, toothache and headache, algalismenorrhea.

Contraindications

hypersensitivity

portal hypertension

alcoholism

pregnancy (I and III trimesters)

lactation.

With caution: congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), children's age (up to 15 years - for a dosage form intended for adults), children's age (up to 6 years for a children's dosage form), angle-closure glaucoma, prostatic hyperplasia, renal failure, glucose-6-phosphate dehydrogenase deficiency.

Use during pregnancy and lactation

Contraindications: pregnancy (I and III trimesters) lactation.

Composition

Active ingredients:

ascorbic acid 100 mg

paracetamol 280 mg

pheniramine maleate 10 mg

Excipients:

aspartame 35 mg,

acesulfame potassium 23 mg,

magnesium citrate 105 mg,

sucrose 71rd mg 2361.7 mg

dye azorubine 4 mg.

Dosage and administration of

For children (children’s dosage form) 6-10 years old - 1 pack. 2 times / day, 10-12 years - 1 pack. 3 times / day, 12-15 years - 1 pack. 4 times / day

Interval between doses - at least 4 hours

In chronic renal failure (CC 10 ml / min) the interval between doses - 8 hours

Side effects

Allergic reactions (skin rash, itching, urticaria, angioedema), nausea, epigastric pain anemia, thrombocytopenia, dry mouth, paresis of accommodation, urinary retention, drowsiness.

With prolonged use in large doses - hepatotoxic effect, hemolytic anemia, aplastic anemia, methemoglobinemia, pancytopenia, erosive and ulcerative lesions of the gastrointestinal tract, bleeding in the gastrointestinal tract nephrotoxicity (papillary necrosis).

Drug Interaction

Ethanol enhances the sedation of antihistamines.

Antidepressants, antiparkinsonian, antipsychotic medicines (phenothiazine derivatives) increase the risk of side effects (urinary retention, dry mouth, constipation).

ACS increase the risk of developing glaucoma.

Inductors of microsomal oxidation (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of severe intoxication with small overdoses.

Microsomal oxidation inhibitors (cimetidine) reduce the risk of hepatotoxic action.

Paracetamol reduces the effectiveness of uricosuric drugs.

overdose

Symptoms (caused by paracetamol): pallor of the skin, decreased appetite, nausea, vomiting, hepatonecrosis (the severity of necrosis due to intoxication depends directly on the degree of overdose).

Toxic effect in adults is possible after ingestion of more than 10-15 g of paracetamol: increased activity of hepatic transaminases, increase of prothrombin time (12-48 h after admission) detailed clinical picture of liver damage manifests itself in 1-6 days. Rarely, liver failure develops rapidly and may be complicated by renal failure (tubular necrosis).

Treatment: in the first 6 hours after overdose - gastric lavage, introduction of donors of SH-groups and precursors of synthesis of glutathione - methionine in 8-9 h after an overdose and N-acetylcysteine ​​after 12 h.

blood, as well as the time elapsed after its ingestion.

Storage conditions

In a dry, dark place at a temperature of no higher than 25 ° C.

The Expiration of

is 3 years.

Deystvuyuschee substances

Paracetamol, phenylephrine, Ascorbic acid



form Dosage form

solution for oral administration

Unique Pharmaceutical, India



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