Rosart tablets are coated. 20 mg 30 pcs. (rosuvastatin)
Special Price
$31.45
Regular Price
$37.00
In stock
SKU
newyork469808
Latin name
Rosart Buy Rosart tablets are coated. 20 mg 30 pcs. (rosuvastatin) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Rosart Buy Rosart tablets are coated. 20 mg 30 pcs. (rosuvastatin) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Latin name
Rosart
Indications
Primary hypercholesterolemia (type IIa by Fredrickson), including heterozygous hereditary hypercholesterolemia) or mixed (combined) hyperlipidemia (type IIb by Fredrickson), as an addition to diet and other non-drug measures (physical activity and weight loss)
Homozygous form of hereditary hypercholesterolemia with insufficient effectiveness of diet therapy and other types of treatment aimed at lowering lipids (for example, LDL apheresis) or, if such treatments are not fit the patient.
Hypertriglyceridemia (type IV Fredrickson supplementation) as a diet supplement.
To slow the progression of atherosclerosis as a supplement to the diet in patients who are shown therapy to lower total cholesterol and LDL cholesterol.
Prevention of major cardiovascular complications (stroke, heart attack, arterial revascularization) in adult patients without clinical signs of coronary heart disease (CHD), but with an increased risk of its development (age over 50 for men and over 60 for women, increased concentration of C-reactive protein ( 2 mg / l) in the presence of at least one of the additional risk factors, such as arterial hypertension, low concentration of HDL cholesterol, smoking, family history of early onset of coronary heart disease).
Contraindications
Hypersensitivity to rosuvastatin or other components of the drug
Diseases of the liver in the active phase, including persistent increase in serum activity of “liver” transaminases (more than 3 times compared with the upper limit of normal (VGN)) of unknown origin
Severe renal impairment (QC less than 30 ml / min)
Myopathy
Simultaneous administration of cyclosporine
Women of reproductive age not using adequate contraceptive methods
Pregnancy and lactation
Age under 18 years (efficacy and safety not established)
Lactose intolerance, lactase deficiency, glucose-galactose malabsorption (prep rat contains lactose monohydrate).
Precautions: The presence of risk factors for the development of myopathy and / or rhabdomyolysis - renal failure (CC more than 30 ml / min), hypothyroidism, personal or family history of hereditary muscle diseases and a previous history of myotoxicity with other HMG-CoA reductase inhibitors or fibrates, excessive alcohol consumption, age over 70 years of age, conditions in which there is an increase in plasma concentration of rosuvastatin race (Mongoloid race), simultaneous use with fiber , a history of liver disease, sepsis, arterial hypotension, extensive surgery, trauma, severe metabolic, endocrine or electrolyte disorders, or uncontrolled epilepsy.
Dosage and administration
Inside, without chewing or grinding, swallow whole, washed down with water, at any time of the day, regardless of food intake.
Before starting therapy with Rosart, the patient should begin to follow a standard lipid-lowering diet and continue to follow it during treatment. The dose of the drug should be selected individually depending on the indications and therapeutic response, taking into account current generally accepted recommendations for target lipid levels. The recommended initial dose of Rosart for patients starting to take the drug, or for patients transferred from taking other HMG-CoA reductase inhibitors, is 5 or 10 mg 1 time / day. When choosing an initial dose, one should be guided by the patient’s cholesterol content and take into account the risk of developing cardiovascular complications, and it is also necessary to assess the potential risk of side effects. If necessary, after 4 weeks the dose of the drug can be increased.
Due to the possible development of side effects when taking a dose of 40 mg compared to lower doses of the drug (see section “Side effects”), the final titration to a maximum dose of 40 mg should be carried out only in patients with severe hypercholesterolemia and a high risk of cardiac -vascular complications (especially in patients with hereditary hypercholesterolemia), in which, when taking a dose of 20 mg, the target cholesterol level was not achieved, and which will be under medical supervision.
Especially careful monitoring of patients receiving the drug in a dose of 40 mg is recommended. After 2-4 weeks of therapy and / or increasing the dose of the drug, monitoring of lipid metabolism is necessary.
Dose adjustment is not required in elderly patients.
In patients with hepatic insufficiency on a Child-Pugh scale below 7, dose adjustment is not required. In patients with values of 8 and 9 on the Child-Pugh scale, a preliminary assessment of renal function should be performed. There is no experience with the use of rosuvastatin in patients with liver failure above 9 points on the Child-Pugh scale.
Dosage adjustment is not required for mild or moderate renal failure. An initial dose of 5 mg is recommended for patients with moderate renal failure (CC less than 60 ml / min). In patients with moderate renal failure (CC less than 30-60 ml / min), a dose of 40 mg is contraindicated. Taking Rosart is contraindicated in all doses to patients with severe renal failure (CC less than 30 ml / min).
Ethnic groups
In patients of the Asian race, an increase in the systemic concentration of rosuvastatin is possible. When prescribing doses of 10 and 20 mg, the initial recommended dose for patients of Asian origin is 5 mg. The use of the drug in a dose of 40 mg is contraindicated in such patients.
Patients predisposed to the development of myopathy
When prescribing doses of 10 and 20 mg, the initial recommended dose for such patients is 5 mg. The use of the drug in a dose of 40 mg in such patients is contraindicated.
Side effects of
From the central nervous system: often - headache, dizziness, asthenic syndrome infrequently - depression, anxiety, insomnia, paresthesia very rarely - peripheral neuropathy, memory loss.
From the digestive system: often - nausea, constipation, abdominal pain infrequently - vomiting, diarrhea, flatulence rarely - pancreatitis very rarely - hepatitis, jaundice.
From the respiratory system: often - pharyngitis infrequently - rhinitis, sinusitis, bronchial asthma, bronchitis, cough, dyspnea, pneumonia.
From the cardiovascular system: infrequently - angina pectoris, increased blood pressure, palpitations, vasodilation.
From the endocrine system: often - diabetes 1. (The overall frequency of 2.8% in the rosuvastatin group and 2.3% in the placebo group, mainly in patients with fasting glucose of 5.6 - 6.9 mmol / l, was reported in the JUPITER study.
From the musculoskeletal system: often - myalgia rarely - arthralgia myopathy (including myositis), rhabdomyolysis, back pain, muscle hypertonicity, pathological fracture of the extremities is very rare - immuno-mediated necrotizing myopathy.
Allergic reactions: infrequently - skin itching, rash, urticaria, rarely - angioedema.
Skin and subcutaneous tissue: frequency unknown - Stevens-Johnson syndrome.
From the urinary system: often - proteinuria (mainly in patients receiving a dose of 40 mg), decreasing during therapy and not associated with the occurrence of kidney disease, urinary tract infections infrequently - peripheral edema, pain in the lower abdomen is very rare - hematuria.
Laboratory indicators: infrequently - transient dose-dependent increase in serum creatine phosphokinase (CK) activity, with an increase of more than 5 times compared with VGN, therapy should be temporarily suspended rarely - a transient increase in the activity of aspartate aminotransferase and alanine aminotransferase.
Other: often - back pain, rhinopharyngitis rarely - decreased potency.
As with other HMG-CoA reductase inhibitors, the incidence is dose-dependent, side effects are usually mild and go away on their own.
Overdose
Treatment: there is no specific treatment, symptomatic therapy is carried out under the control of liver function and CPK activity. Hemodialysis is ineffective.
Storage Conditions
No special storage conditions required. Keep out of reach of children!
Expiration
30 months.
active substance
Rosuvastatin
Terms leave through pharmacies
In retseptu
lekarstvennaja form
tablets
Actavis Ltd, Iceland
Rosart tablets are coated. 20 mg 30 pcs. (rosuvastatin) florida in pharmacy online. Cheap price, instruction, side effects, dosage. Rosart tablets are coated. 20 mg 30 pcs. - Sale. PayPal accept. Free shipping florida. Fast international shipping.
Rosart
Indications
Primary hypercholesterolemia (type IIa by Fredrickson), including heterozygous hereditary hypercholesterolemia) or mixed (combined) hyperlipidemia (type IIb by Fredrickson), as an addition to diet and other non-drug measures (physical activity and weight loss)
Homozygous form of hereditary hypercholesterolemia with insufficient effectiveness of diet therapy and other types of treatment aimed at lowering lipids (for example, LDL apheresis) or, if such treatments are not fit the patient.
Hypertriglyceridemia (type IV Fredrickson supplementation) as a diet supplement.
To slow the progression of atherosclerosis as a supplement to the diet in patients who are shown therapy to lower total cholesterol and LDL cholesterol.
Prevention of major cardiovascular complications (stroke, heart attack, arterial revascularization) in adult patients without clinical signs of coronary heart disease (CHD), but with an increased risk of its development (age over 50 for men and over 60 for women, increased concentration of C-reactive protein ( 2 mg / l) in the presence of at least one of the additional risk factors, such as arterial hypertension, low concentration of HDL cholesterol, smoking, family history of early onset of coronary heart disease).
Contraindications
Hypersensitivity to rosuvastatin or other components of the drug
Diseases of the liver in the active phase, including persistent increase in serum activity of “liver” transaminases (more than 3 times compared with the upper limit of normal (VGN)) of unknown origin
Severe renal impairment (QC less than 30 ml / min)
Myopathy
Simultaneous administration of cyclosporine
Women of reproductive age not using adequate contraceptive methods
Pregnancy and lactation
Age under 18 years (efficacy and safety not established)
Lactose intolerance, lactase deficiency, glucose-galactose malabsorption (prep rat contains lactose monohydrate).
Precautions: The presence of risk factors for the development of myopathy and / or rhabdomyolysis - renal failure (CC more than 30 ml / min), hypothyroidism, personal or family history of hereditary muscle diseases and a previous history of myotoxicity with other HMG-CoA reductase inhibitors or fibrates, excessive alcohol consumption, age over 70 years of age, conditions in which there is an increase in plasma concentration of rosuvastatin race (Mongoloid race), simultaneous use with fiber , a history of liver disease, sepsis, arterial hypotension, extensive surgery, trauma, severe metabolic, endocrine or electrolyte disorders, or uncontrolled epilepsy.
Dosage and administration
Inside, without chewing or grinding, swallow whole, washed down with water, at any time of the day, regardless of food intake.
Before starting therapy with Rosart, the patient should begin to follow a standard lipid-lowering diet and continue to follow it during treatment. The dose of the drug should be selected individually depending on the indications and therapeutic response, taking into account current generally accepted recommendations for target lipid levels. The recommended initial dose of Rosart for patients starting to take the drug, or for patients transferred from taking other HMG-CoA reductase inhibitors, is 5 or 10 mg 1 time / day. When choosing an initial dose, one should be guided by the patient’s cholesterol content and take into account the risk of developing cardiovascular complications, and it is also necessary to assess the potential risk of side effects. If necessary, after 4 weeks the dose of the drug can be increased.
Due to the possible development of side effects when taking a dose of 40 mg compared to lower doses of the drug (see section “Side effects”), the final titration to a maximum dose of 40 mg should be carried out only in patients with severe hypercholesterolemia and a high risk of cardiac -vascular complications (especially in patients with hereditary hypercholesterolemia), in which, when taking a dose of 20 mg, the target cholesterol level was not achieved, and which will be under medical supervision.
Especially careful monitoring of patients receiving the drug in a dose of 40 mg is recommended. After 2-4 weeks of therapy and / or increasing the dose of the drug, monitoring of lipid metabolism is necessary.
Dose adjustment is not required in elderly patients.
In patients with hepatic insufficiency on a Child-Pugh scale below 7, dose adjustment is not required. In patients with values of 8 and 9 on the Child-Pugh scale, a preliminary assessment of renal function should be performed. There is no experience with the use of rosuvastatin in patients with liver failure above 9 points on the Child-Pugh scale.
Dosage adjustment is not required for mild or moderate renal failure. An initial dose of 5 mg is recommended for patients with moderate renal failure (CC less than 60 ml / min). In patients with moderate renal failure (CC less than 30-60 ml / min), a dose of 40 mg is contraindicated. Taking Rosart is contraindicated in all doses to patients with severe renal failure (CC less than 30 ml / min).
Ethnic groups
In patients of the Asian race, an increase in the systemic concentration of rosuvastatin is possible. When prescribing doses of 10 and 20 mg, the initial recommended dose for patients of Asian origin is 5 mg. The use of the drug in a dose of 40 mg is contraindicated in such patients.
Patients predisposed to the development of myopathy
When prescribing doses of 10 and 20 mg, the initial recommended dose for such patients is 5 mg. The use of the drug in a dose of 40 mg in such patients is contraindicated.
Side effects of
From the central nervous system: often - headache, dizziness, asthenic syndrome infrequently - depression, anxiety, insomnia, paresthesia very rarely - peripheral neuropathy, memory loss.
From the digestive system: often - nausea, constipation, abdominal pain infrequently - vomiting, diarrhea, flatulence rarely - pancreatitis very rarely - hepatitis, jaundice.
From the respiratory system: often - pharyngitis infrequently - rhinitis, sinusitis, bronchial asthma, bronchitis, cough, dyspnea, pneumonia.
From the cardiovascular system: infrequently - angina pectoris, increased blood pressure, palpitations, vasodilation.
From the endocrine system: often - diabetes 1. (The overall frequency of 2.8% in the rosuvastatin group and 2.3% in the placebo group, mainly in patients with fasting glucose of 5.6 - 6.9 mmol / l, was reported in the JUPITER study.
From the musculoskeletal system: often - myalgia rarely - arthralgia myopathy (including myositis), rhabdomyolysis, back pain, muscle hypertonicity, pathological fracture of the extremities is very rare - immuno-mediated necrotizing myopathy.
Allergic reactions: infrequently - skin itching, rash, urticaria, rarely - angioedema.
Skin and subcutaneous tissue: frequency unknown - Stevens-Johnson syndrome.
From the urinary system: often - proteinuria (mainly in patients receiving a dose of 40 mg), decreasing during therapy and not associated with the occurrence of kidney disease, urinary tract infections infrequently - peripheral edema, pain in the lower abdomen is very rare - hematuria.
Laboratory indicators: infrequently - transient dose-dependent increase in serum creatine phosphokinase (CK) activity, with an increase of more than 5 times compared with VGN, therapy should be temporarily suspended rarely - a transient increase in the activity of aspartate aminotransferase and alanine aminotransferase.
Other: often - back pain, rhinopharyngitis rarely - decreased potency.
As with other HMG-CoA reductase inhibitors, the incidence is dose-dependent, side effects are usually mild and go away on their own.
Overdose
Treatment: there is no specific treatment, symptomatic therapy is carried out under the control of liver function and CPK activity. Hemodialysis is ineffective.
Storage Conditions
No special storage conditions required. Keep out of reach of children!
Expiration
30 months.
active substance
Rosuvastatin
Terms leave through pharmacies
In retseptu
lekarstvennaja form
tablets
Actavis Ltd, Iceland
Rosart tablets are coated. 20 mg 30 pcs. (rosuvastatin) florida in pharmacy online. Cheap price, instruction, side effects, dosage. Rosart tablets are coated. 20 mg 30 pcs. - Sale. PayPal accept. Free shipping florida. Fast international shipping.
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