Singleon tablets 10 mg, 28 pcs. (Montelukast)
Special Price
$32.30
Regular Price
$38.00
In stock
SKU
newyork467207
Release form
Tablets. Buy Singleon tablets 10 mg, 28 pcs. (Montelukast) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Tablets. Buy Singleon tablets 10 mg, 28 pcs. (Montelukast) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Release form
Tablets.
Packing
28 pcs.
Pharmacological action
Singlon is a blocker of cysteinyl leukotriene receptors CysLT1 (leukotrienes C4, D4 and E4 are mediators of chronic persistent inflammation that supports bronchial hyperresponsiveness in bronchial asthma).
Prevents excessive secretion in the bronchi, swelling of the mucous membrane of the respiratory tract. Reduces the severity of bronchial asthma and the frequency of asthmatic attacks. Highly effective when taken orally.
Bronchodilator action develops within 1 day and lasts a long time.
Effective in patients with mild persistent asthma, not sufficiently controlled by bronchodilators alone.
Contraindications
Hypersensitivity, children's age (up to 6 years).
Caution. Pregnancy, lactation.
Special instructions
The effectiveness of montelukast for oral administration in the treatment of acute asthma attacks has not been established. Therefore, Montelukast for oral administration is not recommended for the treatment of acute attacks of bronchial asthma. Patients should be instructed to always have emergency medications with them to relieve asthma attacks (short-acting inhaled beta2-agonists).
You should not stop taking montelukast during an exacerbation of asthma and the need to use emergency drugs (short-acting inhaled beta2-agonists) to stop attacks.
Patients with a confirmed allergy to acetylsalicylic acid and other NSAIDs should not take these drugs during the treatment with montelukast, since montelukast, while improving respiratory function in patients with allergic bronchial asthma, nevertheless cannot completely prevent bronchoconstriction caused by them.
The dose of inhaled GCS used concomitantly with montelukast can be gradually reduced under the supervision of a doctor, however, abrupt replacement of inhaled or oral GCS with montelukast cannot be performed.
Neuropsychiatric disorders have been described in patients taking montelukast. Considering, that these symptoms could be caused by other factors, it is not known whether they are associated with taking montelukast. The physician needs to discuss these side effects with patients and / or their parents / guardians. Patients and / or their guardians need to be explained that in case of the appearance of such symptoms, it is necessary to inform the attending physician about this.
Reducing the dose of systemic corticosteroids in patients receiving anti-asthma drugs, including leukotriene receptor blockers, was rarely accompanied by the appearance of one or more of the following reactions: eosinophilia, rash, worsening pulmonary symptoms, cardiological complications and / or neuropathy, sometimes diagnosed as Charge-Strauss syndrome , systemic eosinophilic vasculitis. Although a causal relationship between these adverse reactions and therapy with leukotriene receptor antagonists has not been established, caution should be exercised with a corresponding clinical observation when the dose of systemic corticosteroids is reduced in patients receiving Montelukast.
Composition
1 film-coated tablet contains:
Active ingredient:
montelukast sodium, which corresponds to the content of montelukast 10 mg,
Excipients:
lactose monohydrate,
cellulose microlose micrord stearate.
Composition of the shell:
opadry yellow 20B32427
Dosage and administration of
Singlon taken orally, regardless of food intake.
Adults and teenagers over 15 years of age - 10 mg once a day, at bedtime.
Children 6-14 years old - 5 mg / day.
Side effects srdl vayuschey blood system: increased tendency to bleeding
Immune system:. hypersensitivity reactions, including anaphylaxis is very rare (
the part of the psyche: agitation (including aggressive behavior or hostility), anxiety, depression, disorientation, pathological dreams, hallucinations, insomnia, irritability, anxiety, somnambulism, suicidal thoughts and behavior (suicidality), tremor.
From the nervous system: dizziness, drowsiness, paresthesia / hypesthesia is very rare (<1/10 000) - cramps.
From the cardiovascular system: tachycardia.
From the respiratory system: nosebleeds, upper respiratory tract infections.
From the digestive system: diarrhea, dyspepsia, nausea, vomiting, pancreatitis, increased activity of ALT and ACT in the blood is very rare (
From the skin and subcutaneous tissues: tendency to form hematomas, erythema nodosum, erythema multiforme, pruritus, rash.
Allergic reactions: angioedema, urticaria.
From the musculoskeletal system: arthralgia, myalgia, including muscle cramps.
On the part of the body as a whole: asthenia (weakness) / fatigue, edema, pyrexia.
Drug Interactions
With simultaneous use with phenobarbital, AUC of montelukast decreased by about 40% (correction of montelukast regimen is not required).
In vitro studies have found that montelukast inhibits the CYP2C8 isoenzyme, however, in vivo studies of the drug interaction of montelukast and rosiglitazone (metabolized with the CYP2C8 isoenzyme), there is no evidence that montelukast inhibits the CYP2C8 isoenzyme. Therefore, in clinical practice, the effect of montelukast on CYP2C8-mediated metabolism of a number of drugs, including paclitaxel, rosiglitazone, repaglinide.
Montelukast is a reasonable supplement to monotherapy with bronchodilators, if the latter do not provide adequate control of bronchial asthma. Upon reaching the therapeutic effect of treatment with montelukast, a gradual reduction in the dose of bronchodilators can begin.
The use of montelukast provides an additional therapeutic effect in patients receiving inhaled corticosteroids. Upon reaching stabilization, you can begin to gradually reduce the dose of corticosteroids under the supervision of a doctor. In some cases, the complete cancellation of inhaled GCS is acceptable, however, a sharp replacement of inhaled corticosteroids with montelukast is not recommended.
Overdose
No specific information is available on the treatment of overdose with Singlon. Data on overdose symptoms when taking the drug in adult patients with bronchial asthma at a dose exceeding 200 mg / day for 22 weeks and at a dose of 900 mg / day for 1 week were not found.
There have been cases of acute overdose of montelukast in adults and children at a dose above 1000 mg (approximately 61 mg / kg for a child aged 42 months). The clinical and laboratory results obtained were consistent with the safety profile for adults and pediatric patients.
The most common adverse events were consistent with Montelukast's safety profile and included abdominal pain, drowsiness, mydriasis, thirst, headache, vomiting, and psychomotor hyperactivity.
There is no evidence of the possibility of eliminating montelukast during peritoneal dialysis or hemodialysis.
Active ingredient
Montelukast
Terms and conditions
prescription
Dosage form
tablets
Appointment by
Children by appointment of doctor, Children over 15 years, Adults by appointment of doctor
Indications
bronchospasm, asthma Bronhyalnaya
Singleon tablets 10 mg, 28 pcs. (Montelukast) newyork in pharmacy online. Cheap price, instruction, side effects, dosage. Singleon tablets 10 mg, 28 pcs. - Sale. PayPal accept. Free shipping newyork. Fast international shipping.
Tablets.
Packing
28 pcs.
Pharmacological action
Singlon is a blocker of cysteinyl leukotriene receptors CysLT1 (leukotrienes C4, D4 and E4 are mediators of chronic persistent inflammation that supports bronchial hyperresponsiveness in bronchial asthma).
Prevents excessive secretion in the bronchi, swelling of the mucous membrane of the respiratory tract. Reduces the severity of bronchial asthma and the frequency of asthmatic attacks. Highly effective when taken orally.
Bronchodilator action develops within 1 day and lasts a long time.
Effective in patients with mild persistent asthma, not sufficiently controlled by bronchodilators alone.
Contraindications
Hypersensitivity, children's age (up to 6 years).
Caution. Pregnancy, lactation.
Special instructions
The effectiveness of montelukast for oral administration in the treatment of acute asthma attacks has not been established. Therefore, Montelukast for oral administration is not recommended for the treatment of acute attacks of bronchial asthma. Patients should be instructed to always have emergency medications with them to relieve asthma attacks (short-acting inhaled beta2-agonists).
You should not stop taking montelukast during an exacerbation of asthma and the need to use emergency drugs (short-acting inhaled beta2-agonists) to stop attacks.
Patients with a confirmed allergy to acetylsalicylic acid and other NSAIDs should not take these drugs during the treatment with montelukast, since montelukast, while improving respiratory function in patients with allergic bronchial asthma, nevertheless cannot completely prevent bronchoconstriction caused by them.
The dose of inhaled GCS used concomitantly with montelukast can be gradually reduced under the supervision of a doctor, however, abrupt replacement of inhaled or oral GCS with montelukast cannot be performed.
Neuropsychiatric disorders have been described in patients taking montelukast. Considering, that these symptoms could be caused by other factors, it is not known whether they are associated with taking montelukast. The physician needs to discuss these side effects with patients and / or their parents / guardians. Patients and / or their guardians need to be explained that in case of the appearance of such symptoms, it is necessary to inform the attending physician about this.
Reducing the dose of systemic corticosteroids in patients receiving anti-asthma drugs, including leukotriene receptor blockers, was rarely accompanied by the appearance of one or more of the following reactions: eosinophilia, rash, worsening pulmonary symptoms, cardiological complications and / or neuropathy, sometimes diagnosed as Charge-Strauss syndrome , systemic eosinophilic vasculitis. Although a causal relationship between these adverse reactions and therapy with leukotriene receptor antagonists has not been established, caution should be exercised with a corresponding clinical observation when the dose of systemic corticosteroids is reduced in patients receiving Montelukast.
Composition
1 film-coated tablet contains:
Active ingredient:
montelukast sodium, which corresponds to the content of montelukast 10 mg,
Excipients:
lactose monohydrate,
cellulose microlose micrord stearate.
Composition of the shell:
opadry yellow 20B32427
Dosage and administration of
Singlon taken orally, regardless of food intake.
Adults and teenagers over 15 years of age - 10 mg once a day, at bedtime.
Children 6-14 years old - 5 mg / day.
Side effects srdl vayuschey blood system: increased tendency to bleeding
Immune system:. hypersensitivity reactions, including anaphylaxis is very rare (
the part of the psyche: agitation (including aggressive behavior or hostility), anxiety, depression, disorientation, pathological dreams, hallucinations, insomnia, irritability, anxiety, somnambulism, suicidal thoughts and behavior (suicidality), tremor.
From the nervous system: dizziness, drowsiness, paresthesia / hypesthesia is very rare (<1/10 000) - cramps.
From the cardiovascular system: tachycardia.
From the respiratory system: nosebleeds, upper respiratory tract infections.
From the digestive system: diarrhea, dyspepsia, nausea, vomiting, pancreatitis, increased activity of ALT and ACT in the blood is very rare (
From the skin and subcutaneous tissues: tendency to form hematomas, erythema nodosum, erythema multiforme, pruritus, rash.
Allergic reactions: angioedema, urticaria.
From the musculoskeletal system: arthralgia, myalgia, including muscle cramps.
On the part of the body as a whole: asthenia (weakness) / fatigue, edema, pyrexia.
Drug Interactions
With simultaneous use with phenobarbital, AUC of montelukast decreased by about 40% (correction of montelukast regimen is not required).
In vitro studies have found that montelukast inhibits the CYP2C8 isoenzyme, however, in vivo studies of the drug interaction of montelukast and rosiglitazone (metabolized with the CYP2C8 isoenzyme), there is no evidence that montelukast inhibits the CYP2C8 isoenzyme. Therefore, in clinical practice, the effect of montelukast on CYP2C8-mediated metabolism of a number of drugs, including paclitaxel, rosiglitazone, repaglinide.
Montelukast is a reasonable supplement to monotherapy with bronchodilators, if the latter do not provide adequate control of bronchial asthma. Upon reaching the therapeutic effect of treatment with montelukast, a gradual reduction in the dose of bronchodilators can begin.
The use of montelukast provides an additional therapeutic effect in patients receiving inhaled corticosteroids. Upon reaching stabilization, you can begin to gradually reduce the dose of corticosteroids under the supervision of a doctor. In some cases, the complete cancellation of inhaled GCS is acceptable, however, a sharp replacement of inhaled corticosteroids with montelukast is not recommended.
Overdose
No specific information is available on the treatment of overdose with Singlon. Data on overdose symptoms when taking the drug in adult patients with bronchial asthma at a dose exceeding 200 mg / day for 22 weeks and at a dose of 900 mg / day for 1 week were not found.
There have been cases of acute overdose of montelukast in adults and children at a dose above 1000 mg (approximately 61 mg / kg for a child aged 42 months). The clinical and laboratory results obtained were consistent with the safety profile for adults and pediatric patients.
The most common adverse events were consistent with Montelukast's safety profile and included abdominal pain, drowsiness, mydriasis, thirst, headache, vomiting, and psychomotor hyperactivity.
There is no evidence of the possibility of eliminating montelukast during peritoneal dialysis or hemodialysis.
Active ingredient
Montelukast
Terms and conditions
prescription
Dosage form
tablets
Appointment by
Children by appointment of doctor, Children over 15 years, Adults by appointment of doctor
Indications
bronchospasm, asthma Bronhyalnaya
Singleon tablets 10 mg, 28 pcs. (Montelukast) newyork in pharmacy online. Cheap price, instruction, side effects, dosage. Singleon tablets 10 mg, 28 pcs. - Sale. PayPal accept. Free shipping newyork. Fast international shipping.
Submit your review to Earn 10 Reward Points click here to login
Write Your Own Review