Sodium chloride solution for infusion 0.9% vial 100 ml (Sodium chloride)

Release form

Solution for infusion 0.9%

Packaging

100 ml - glass bottles (1) - packs of cardboard.

Pharmacological action

It has a detoxifying and rehydrating effect. Replenishes sodium deficiency in various pathological conditions of the body and temporarily increases the volume of fluid circulating in the vessels.

The pharmacodynamic properties of the solution are due to the presence of sodium ions and chloride ions. A number of ions, including sodium ions, penetrate the cell membrane using various transport mechanisms, among which the sodium-potassium pump (Na-K-ATPase) is of great importance. Sodium plays an important role in signaling in neurons, electrophysiological processes of the heart, as well as in metabolic processes in the kidneys.

Sodium is excreted mainly by the kidneys, however, a large amount of sodium undergoes reabsorption (renal reabsorption). A small amount of sodium is excreted in feces and during perspiration.

Indications

isotonic extracellular dehydration

hyponatremia

dilution and dissolution of parenteral drug (as a base solution).

Contraindications

hypernatremia, acidosis, hyperchloremia, hypokalemia extracellular hyperhydration

circulatory disorders, threatening cerebral and pulmonary edema

cerebral edema, pulmonary edema, acute left ventricular failure, concomitant administration of corticosteroids in large doses.

When adding other drugs to the solution, contraindications to these drugs should be considered.

Precautions: decompensated chronic heart failure, arterial hypertension, peripheral edema, preeclampsia, chronic renal failure (oligo-, anuria), aldosteronism and other conditions associated with sodium retention in the body.

Use during pregnancy and lactation

The solution can be administered during pregnancy and lactation.

Composition of

100 ml of the solution contains: 900 mg sodium chloride

Dosage and Administration

Intravenously (usually drip). The required dose can be calculated in mEq or mmol of sodium, mass of sodium ions or mass of sodium chloride (1 g NaCl = 394 mg, 17.1 mEq or 17.1 mmol of Na and Cl).

The dose is determined depending on the condition of the patient, the loss of body fluid, Na + and Cl-, age, body weight of the patient. Serum concentrations of electrolytes in plasma and urine should be carefully monitored.

The dose of sodium chloride solution for adults is from 500 ml to 3 liters per day.

The dose of sodium chloride solution for children is from 20 ml to 100 ml per day per kg body weight (depending on age and total body weight). The rate of administration depends on the condition of the patient.

The recommended dose when used to dilute and dissolve parenteral-administered drugs (as a basic solvent solution) is in the range from 50 ml to 250 ml per dose of the drug administered. In this case, the dose and rate of administration of the solution are determined by the recommendations for the use of the administered drug.

Side effects

Acidosis, hyperhydration, hypokalemia.

When used correctly, undesirable effects are unlikely.

When using sodium chloride solution 0. 9% as a base solution (solvent) for other drugs, the probability of side effects is determined by the properties of these drugs. In this case, if adverse reactions occur, the administration of the solution should be suspended, the patient's condition should be assessed, adequate measures should be taken, and the remaining solution should be retained for analysis, if necessary.

Drug Interaction

Not described.

When mixed with other medicines, it is necessary to visually check compatibility. For this purpose it is necessary to observe the obtained solution for the change of its color and / or precipitation, the appearance of crystals, insoluble complexes. Instructions for the use of added drugs should also be taken into account.

Overdose

Symptoms: nausea, vomiting, diarrhea, spastic abdominal pain, thirst, decreased saliva and tearing, sweating, fever, tachycardia, increased blood pressure, renal insufficiency, periwinkle, periwinkle, dizziness, anxiety, irritability, weakness, muscle cramps and rigidity, generalized seizures, coma and death. Excessive administration of the solution may cause hypernatremia.

Excess chloride intake can lead to hyperchloric acidosis.

When used as a stock solution for dilution and dissolution of other drugs, symptoms and complaints in excess administration are most often associated with the properties of the drugs administered.

In case of unintentional excess administration of the solution, treatment should be discontinued and the patient's condition assessed.

Treatment: symptomatic.

Storage conditions

At a temperature not exceeding 25 ° C. Keep out of the reach of children.

Expiration

Expiration 100 ml - 2 years.

Active ingredient

Sodium chloride

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