Sulfacyl sodium eye drops 20% vial 5 ml (sulfacetamide)

Pharmacological action

Antimicrobial bacteriostatic agent, sulfonamide.

The mechanism of action is due to competitive antagonism with para-aminobenzoic acid (PABA), inhibition of dihydropteroate synthetase, impaired synthesis of tetrahydrofolate acid, necessary for the synthesis of purines and pyrimidines. Active against gram-positive and gram-negative cocci, Escherichia coli, Shigella spp., Vibrio cholerae, Clostridium perfringens, Bacillus anthracis, Corynebacterium diphtheriae, Yersinia pestis, Chlamydia spp., Actinomyces israelii, Toxoplasma gondii.

Pharmacokinetics

Penetrates into the tissues and fluids of the eye. It is absorbed into the systemic circulation through the inflamed conjunctiva. When applied topically, the maximum concentration of sulfonamides in the cornea (about 3 mg / ml), moisture in the anterior chamber (about 0.5 mg / ml) and the iris (about 0.1 mg / ml) is reached in the first 30 minutes after application.

A certain amount (less than 0.5 mg / ml) is stored in the tissues of the eyeball for 3-4 hours. If corneal epithelium is damaged, penetration of sulfonamides is enhanced.

Indications

Conjunctivitis, blepharitis, purulent corneal ulcer, prevention and treatment of blennorrhea in newborns, gonorrheal and chlamydial eye diseases in adults.

Contraindications

Hypersensitivity.

Use during pregnancy and lactation

It is possible to use riboflavin during pregnancy and lactation (breastfeeding) according to the indications for the mother outweighs the potential risk to the fetus and the baby.

Special instructions

Patients with hypersensitivity to furosemide, thiazide diuretics, sulfonylurea or carbonic anhydrase inhibitors may have an increased sensitivity to sulfacetamide.

Composition of

per 1 ml: active substance:

sodium sulfacetamide - 200 mg

excipients:

sodium thiosulfate - 1.5 mg,

1 M hydrochloric acid solution - up to pH 7.7 to 8.7,

water for injection - up to 1 ml.

Dosage and administration

Topically, instill 1-2 drops in each conjunctival sac 4-6 times a day.

For the prevention of blennorrhea in newborns - 2 drops in each conjunctival sac immediately after birth and 2 drops after 2 hours.

Side effects

Burning, lacrimation, pain, itching in the eyes, allergic reactions.

Drug Interactions

Co-administration with procaine and tetracaine reduces the bacteriostatic effect.

Incompatible with silver salts.

Storage conditions

In a dark place at a temperature of 15 to 25 ° C.

Keep out of the reach of children.

Term hodnosty

2 years

Active ingredient

Sulfacetamide

Pharmacy terms

OTC

Form of Treatment

rims glazn e



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