sulfadimezin tablets 500 mg, 10 pcs. (Sulphadimidine)

Release form

Tablets are white or white with a slightly yellowish tinge, are flat-cylindrical, with bevel and notch.

Packing

Per pack 10 pcs.

Pharmacological action

Antimicrobial bacteriostatic agent, sulfonamide. The mechanism of action is due to competitive antagonism with para-aminobenzoic acid, inhibition of dihydropteroate synthase, impaired synthesis of tetrahydrofolate acid, necessary for the synthesis of purines and pyrimidines. Active against gram-positive and gram-negative cocci, Escherichia coli, Shigella spp., Klebsiella spp., Vibrio cholerae, Clostridium perfringens, Bacillus anthracis, Corynebacterium diphtheriae, Yersinia pestis, Chlamydia scesii, Act.

Pharmacokinetics

Absorption - fast (mainly in the small intestine). Communication with plasma proteins -75-86%. It penetrates well into tissues (including the lungs, cerebrospinal fluid). It is metabolized in the liver by acetylation. The half-life (T1 / 2) is 7 hours. It is excreted by the kidneys by glomerular filtration. Acetylated metabolites when concentrated in the urine may precipitate. The solubility of metabolites improves with alkalization of urine.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug: - respiratory infections (including bronchitis, pneumonia - s) including sinusitis, pharyngitis, tonsillitis, acute otitis media)

- infections of the genitourinary system (including pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea)

- gynecological infections (including endometritis, cervicitis)

- gastrointestinal tract infections (including peritonitis, ent rokolit, typhoid fever, cholangitis, cholecystitis)

- skin and soft tissue infections (including erysipelas, impetigo, secondarily infected dermatoses)

- leptospirosis

- listeriosis

- Lyme disease (borreliosis)

- dysentery

- salmonellosis, salmonella carriage

- meningitis

- endocarditis sp1011 microorganisms: tonsillitis, sinusitis, otitis media, exacerbation of chronic bronchitis, pneumonia, inflammatory diseases of the biliary and urinary tract, shigellosis, erysipelas, wound infection.

Contraindications

Hypersensitivity, inhibition of bone marrow hematopoiesis, chronic renal failure, hyperbilirubinemia in children (risk of bilirubin encephalopathy), congenital deficiency of glucose-6-phosphate dehydrogenase, porphyria, azemia, pregnancy.

Use during pregnancy and lactation

Contraindicated in pregnancy and lactation.

Special instructions

A generous alkaline drink is recommended during therapy. With prolonged use, monitoring of peripheral blood parameters is necessary.

Composition

1 tablet contains: sulfadimidine 500 mg.

Excipients: potato starch, talc, stearic acid, polysorbate 80.

Dosage and administration

Inside, 1 g 4-6 times a day. With pneumonia and meningitis at the first dose - 2 g for children - at the rate of 0.1 g / kg at the first dose, then 0.25 g / kg every 4, 6, 8 hours. Higher doses for adults: single - 2 g, daily - 7 g for children under 1 year old, daily - 0.15 g / kg, over 1 year old daily - 0.1-0.15 g / kg. With dysentery, 2 courses of treatment are performed. The first course: on the 1st and 2nd day - 1 g every 4 hours (total 6 g / day), on the 3rd and 4th day - 1 g every 6 hours (4 g / day), on the 5th and 6th day - 1 g every 8 hours ( 3 g / day). After 5-6 days, the second course is carried out: 1 and 2 days - 1 g every 4 hours, at night - after 8 hours (total 5 g / day), 3 and 4 days - 1 g after 4 hours (4 g / day, do not give at night), 5 day - 3 g / day.

Drug Interactions

Reduces the effectiveness of bactericidal antibiotics that act only on fissile microorganisms (including penicillins and cephalosporins). Increases (mutually) hematotoxicity of chloramphenicol, tiamazole. Benzocaine, procaine reduce antimicrobial activity (PABA is released during hydrolysis). Ascorbic acid, hexamethylenetetramine increase the risk of crystalluria. NSAIDs, hypoglycemic drugs (sulfonylurea derivatives), phenytoin and coumarin anticoagulants increase the severity of side effects. Antacids reduce intestinal absorption. With toxoplasmosis, a combination with pyrimethamine is possible. Myelotoxic drugs increase the manifestations of hematotoxicity of the drug.

Storage conditions

In a dark place at a temperature not exceeding 20 ° C.

Expiration

2 years.

Deystvuyuschee substances

Sulphadimidine

Terms of delivery from

pharmacies Prescription

Form of Treatment

tablets

Irbitskij HFZ, Russia



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