Sumamed tablets are coated.pl.ob. 500 mg 3 pcs. (Azithromycin)

packaging 3 pcs

Pharmacological action

Antibiotic macrolide group - azalide. It has a wide range of antimicrobial effects. It binds to the 50S subunit of the ribosome, inhibits the biosynthesis of protein microorganisms. In high concentrations it has a bactericidal effect.

Azithromycin is active against gram-positive aerobic bacteria: Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus viridans, streptococci of groups C, F and G, Staphylococcus aureus, Staphylococcus epidermidis of some gram-positive anaerobic bacteria: Clostridium perfringens.

Azithromycin is active against gram-negative aerobic bacteria: Haemophilus influenzae, Haemophilus parainfluenzae, Haemophilus ducreyi, Moraxella catarrhalis, Bordetella pertussis, Bordetella parapertisseris, Berlissa mellis infection, Neisseria gonorrrhoeae, Jerisseri malaria

Azithromycin is also active against intracellular and other microorganisms: Mycobacterium avium complex, Legionella pneumophila, Chlamydia trachomatis, Chlamydia pneumoniae, Mycoplasma pneumoniae, Ureaplasma urealyticum, Listeria monocitogenes, Borrelia burgerferma burgfer.

Gram-positive bacteria resistant to erythromycin are resistant to the drug.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug: - infections of the upper respiratory tract and ear (bacterial pharyngitis, tonsillitis, sinusitis, otitis media)

- infections of the lower respiratory tract (bacterial bronchitis, interstitial pneumonia exacerbation of chronic bronchitis)

- infections of the skin and soft tissues (chronic migratory erythema - the initial stage, Lyme disease, erysipelas, impetigo, secondary dermatoses)

- sexually transmitted infections (urethritis, cervicitis)

- diseases of the stomach and duodenum associated with Helicobacter pylori.

Contraindications

- severe hepatic and renal impairment

- hypersensitivity to the

macrolide group antibiotics Precautions: during pregnancy and lactation, with impaired liver and kidney function, in patients with impaired or predisposed arrhythmias and QT prolongation.

Use during pregnancy and lactation

During pregnancy, the drug should be administered only if the expected benefit to the mother outweighs the potential risk to the fetus. If it is necessary to administer Sumamed to women during lactation, it is necessary to decide on the termination of breastfeeding.

Composition

1 tablet contains azithromycin dihydrate 500 mg

Side effects

Rarely (in 1% of cases or less).

From the digestive system: melena, cholestatic jaundice, nausea, vomiting, diarrhea, constipation, decreased appetite, gastritis, a reversible moderate increase in the activity of liver enzymes.

From the urinary system: jade.

From the reproductive system: vaginal candidiasis.

From the cardiovascular system: palpitations, chest pain.

From the side of the central nervous system and peripheral nervous system: dizziness, headache, vertigo, drowsiness, increased fatigue in children - headache (with treatment of otitis media), hyperkinesia, anxiety, neurosis, sleep disturbances.

Allergic reactions: skin rashes, Quincke's edema, urticaria, conjunctivitis.

Dermatological reactions: photosensitivity, pruritus.

On the part of laboratory parameters: in some cases - neutrophilia, eosinophilia (changed indicators return to normal 2-3 weeks after discontinuation of treatment).

Drug Interactions

Antacids (containing aluminum, magnesium), ethanol and food greatly reduce the absorption of azithromycin (capsules and suspension), so the drug should be taken at least 1 hour before or after 2 hours drugs and food.

Azithromycin, unlike other macrolide antibiotics, does not bind to isoenzymes of the cytochrome P450 system. No interactions with theophylline, terfenadine, carbamazepine, triazolam, digoxin have been reported to date.

Macrolides with simultaneous standard receiving with cycloserine, nepryam my anticoagulants, methylprednisolone, felodypynom and drugs podverhayuschymysya mykrosomalnomu oxidation (cyclosporine, heksobarbytal, alkaloyd spor ny, valproevaya acid dyzopyramyd, bromocriptine, fenytoyn, oral hypohlykemycheskye sredstva) zamedlyayut withdrawal, pov shayut concentrations and toxicity ukazann h drugs, while the use of azalides such interaction has not been observed to date.

Careful monitoring of prothrombin time is recommended when co-administered with warfarin.

The simultaneous administration of macrolides with ergotamine and dihydroergotamine may result in their toxic effect (vascular spasm, dysesthesia).

Linkosamines decrease and tetracycline and chloramphenicol increase the effectiveness of azithromycin.

Pharmaceutically azithromycin incompatible with heparin.

Overdose

Symptoms: nausea, vomiting, diarrhea, temporary hearing loss.

Treatment: symptomatic.

Storage conditions

Keep out of the reach of children at temperatures from 15 ° to 25 ° C.

Expiration

3 years.

Active ingredient

Azithromycin

Pharmacy terms

Prescription

dosage form

dosage form

tablets

Pliva Hrvatska d.o., Croatia



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