Tabex tablets 1.5 mg, 100 pcs. (Cytisine)

Packing

100 pcs.

Pharmacological action

Tabex - N-cholinomimetic. A herbal preparation containing an alkaloid, isolated from the plant Cytisus laburnum (broom). The mechanism of action is similar to nicotine, but differs in greater therapeutic breadth.

Stimulates the nicotinic receptors of the autonomic ganglia, irritates the carotid sinus chemoreceptors, and causes the adrenaline to be released from the adrenal glands. Increases blood pressure and stimulates respiration in a reflexive way.

When smoking with Tabex, the effect of nicotine is combined with the effect of cytisine, which leads to the appearance of unpleasant symptoms of nicotine overdose. This makes the patient gradually stop smoking, without experiencing withdrawal symptoms, as the action of nicotine is replaced by the action of cytisine.

Indications

Chronic nicotinism (for smoking cessation).

Contraindications

hypersensitivity to the active or any of the excipients of the drug Tabex

acute myocardial infarction

unstable angina pectoris

cardiac arrhythmia

recent stroke (at least 1 month before the drug is started) hypertension glucose-galactose malabsorption syndrome (lactose is part of the drug)

pregnancy

breastfeeding period

age before 18 and after 65 le t

Precautions: coronary heart disease (stable angina pectoris, asymptomatic (silent) myocardial ischemia, vasospastic angina pectoris, X syndrome (microvascular angina) heart failure, increased blood pressure of cerebrovascular disease obliterating arterial diseases hyperthyroidism peptic ulcer disease diabetes mellitus renal or hepatic insufficiency some forms of schizophrenia presence of chromaffin adrenal tumors gastroesophageal reflux disease of over 45 years old and older .

Use of the drug in patients with the diseases indicated in the Precautions section is possible only after consulting a doctor.

Use during pregnancy and lactation

It is not recommended to prescribe Tabex during pregnancy because of the potential risk of embryotoxic effects if uncontrolled.

It is not recommended to take the drug during lactation.

Special instructions

The drug should be used only if the patient has a serious and conscious intention to quit smoking.

Patient should be warned that that the use of the drug against the background of continued smoking can lead to nicotine intoxication.

There is insufficient clinical experience with Tabex in patients with coronary artery disease, heart failure, cerebrovascular disease, hyperthyroidism, diabetes mellitus, renal and hepatic insufficiency. For these categories of patients, the drug should be prescribed only after assessing the benefit / risk ratio.

Influence on the ability to drive vehicles and control mechanisms

Taking the drug does not cause changes in the psychophysical state of the patient, does not impair the ability to drive vehicles and work with mechanisms.

Composition

1 tablet contains cytisine 1.5 mg

excipients: calcium phosphate disubstituted, milk sugar, wheat starch, microcrystalline cellulose, talc, magnesium stearate

Dosage and administration of

Tabex is prescribed for 3 days, 1 tab. 6 times / day (after 2 hours) with a parallel reduction in the number of cigarettes smoked. If after 3 days there is no result from treatment, the drug should be discontinued and after 2-3 months start a new course.

If the result is positive, treatment is continued according to the following scheme:

Treatment period

Frequency of

intake Daily dose of

from 4 to 12 days, 1 tab. every 2.5 hours 5 tablets

from 13 to 16 days to 1 tab. every 3 hours 4 tablets

from 17 to 20 days for 1 tab. every 5 hours 3 tablets

from 21 to 25 day for 1 tab. every 6-8 hours 1-2 tab.

Smoking should be stopped no later than 5 days from the start of treatment.

At the end of the course of treatment, in order for the result to remain positive, the patient must completely stop smoking.

Side effects

Clinical studies and post-marketing observations have shown that the drug is well tolerated. The observed side effects are mild or moderate. Most of them occur at the beginning of treatment and pass on their own. Most often, they are associated with smoking cessation and are manifested by dizziness, headache and insomnia.

At the recommended doses, Tabex does not cause serious adverse effects.

The following side effects are possible.

From the CCC side: tachycardia, a slight increase in blood pressure, a feeling of palpitations.

From the side of the central nervous system: headache, dizziness, insomnia or drowsiness, increased irritability.

From the respiratory system: shortness of breath.

From the digestive tract: dry mouth, nausea, abdominal pain, constipation, diarrhea, changes in taste and appetite.

From the side of musculoskeletal and connective tissue: muscle pain.

From the side of metabolism and nutrition: weight loss, increased sweating.

Other: chest pain.

Drug Interactions

After cessation of smoking, the side effects of theophylline, ropinirole, clozapine and olanzapine may increase.

With the simultaneous use of Tabexx with acetylcholine, carbachol, galantamine, pyridostigmine, revastigmine, distigmine, it is possible to increase cholinomimetic side effects (salivation, lacrimation, bronchial secretion with cough and the risk of an asthma attack, narrowing of the pupil, nausea, nausea, nausea, nausea muscle tone or sudden muscle contractions).

The use of Tabex concomitantly with HMG-CoA reductase inhibitors (including lovastatin, simvastatin, fluvastatin, pravastatin) increases the risk of muscle pain.

The simultaneous use of Tabexx with antihypertensive drugs (including propranolol) can weaken their effect.

Overdose

Symptoms: nausea, vomiting, pupil enlargement, general weakness, tachycardia, clonic convulsions, respiratory paralysis.

Treatment: intake of activated charcoal, gastric lavage, infusion of water-saline solutions, as well as 5 or 10% glucose solution, appointment of anticonvulsants, cardiotonics, respiratory analeptics and other symptomatic agents. Respiratory, blood pressure, and heart rate should be monitored.

Storage Conditions

The product should be stored in a dry, direct sunlight location at 15 ° C to 25 ° C.

shelf life

2 years

dosage form

tablets

Possible product names

TABEX 0.0015 N100 TABLE P / O

TABEX 1.5MG. No. 100 TAB. P / O

Tabex 1.5mg Tab. p / pl / rev X100

Tabex Tab p / o 1.5mg x 100

Tabex Tab p / p / o 1.5mg N100



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