The control of the tablet is coated. 20 mg, 14 pcs. (Pantoprazole)

Packing

14 pcs

Indications

Indications for gastric and duodenal ulcer (treatment and eradication of Helicobacter pylori infection)

Contraindications

Hypersensitivity to dyspepsia of neurotic origin (tablets).

Precautions: pregnancy, lactation, liver failure.

Use during pregnancy and lactation

Control should be used with caution during pregnancy and lactation.

Composition

1 tablet contains:

Active substances: pantoprazole sodium sesquihydrate 22.57 mg (corresponding to 20 mg pantoprazole) pantoprazole sodium sesquihydrate45, 1 mg (corresponds to 40 mg of pantoprazole)

Excipients: sodium carbonate anhydrous mannitol crospovidone povidone K90 calcium stearate purified water

Shell: 2910 pomeridone p25 povidone titanium dioxide (E171) iron oxide yellow (E172) propylene glycol 30 acid and ethyl acrylate copolymer, polysorbate 80, sodium lauryl sulfate) triethyl citrate.

Dosage and administration

Inside, washed down with liquid and swallowed whole (tablets cannot be crushed or dissolved).

Peptic ulcer of the stomach and duodenum, erosive gastritis (including those associated with NSAIDs): 40–80 mg / day. The course of treatment is 2 weeks for exacerbation of duodenal ulcer and 4-8 weeks for exacerbation of gastric ulcer. Anti-relapse treatment of peptic ulcer of the stomach and duodenum - 20 mg / day.

Eradication of Helicobacter pylori. The following combinations are recommended: Kontrolok® 20 mg 2 times a day + amoxicillin 1000 mg 2 times a day + clarithromycin 500 mg 2 times a day

Kontrolok® 20 mg 2 times a day + metronidazole 500 mg 2 times a day + clarithromycin 500 mg 2 times a day

Control® 20 mg 2 times a day + amoxicillin 1000 mg 2 times a day + metronidazole 500 mg 2 times a day.

The course of treatment is 7-14 days.

Reflux esophagitis: 20–40 mg / day. The course of treatment is 4-8 weeks. Anti-relapse treatment - 20 mg / day.

Zollinger-Ellison Syndrome: 40–80 mg / day. In patients with severe hepatic impairment, the dose should be reduced to 40 mg once every 2 days. In this case, it is necessary to control the biochemical parameters of the blood. With an increase in the level of liver enzymes, the use of the drug should be discontinued.

elderly patients and also for patients with impaired renal function, the daily dose of 40 mg should not be exceeded. An exception is the use of combination antimicrobial therapy against Helicobacter pylori, when elderly patients should use the drug Controlok 40 mg 2 times a day.

According to indications requiring taking the drug once a day, the drug Controlok® should be taken in the morning. It was established that neither the time of day, nor food intake affects the activity of the drug, but the recommended time for taking Controlok® tablets contributes to better patient compliance with the treatment regimen.

Drug Interaction

Concomitant use of Kontrolok® may reduce the absorption of drugs whose bioavailability depends on the pH of the stomach (eg iron salts, ketoconazole).

Kontrolok®, unlike other proton pump inhibitors, can be prescribed without the risk of drug interaction: patients with cardiovascular diseases receiving cardiac glycosides (digoxin), BKK (nifedipine), -adrenergic blockers (metoprolol)

patients with gastrointestinal diseases, receiving antacids, antibiotics (antibiotics), antibiotics oral contraceptives

to patients receiving NSAIDs (diclofenac, phenazone, naproxen, piroxicam)

to patients with endocrine diseases receiving glibenclamide, levothyroxine

to patients with anxiety conditions and sleep disorders receiving diazepam

in patients with epilepsy receiving carbamazepine and phenytoin

in patients receiving indirect anticoagulants such as warfarin and fenprocoumon

in patients undergoing tacrolimporin transplantation receiving cyclosporin.

There was also a lack of drug interaction with theophylline, caffeine and ethanol.

Interaction with atazanavir and ritonavir (tablets) is possible.

Overdose

To date, no overdose has been reported with the use of the drug. Doses up to 240 mg were administered in / over for 2 min and were well tolerated. However, in case of overdose and only in the presence of clinical manifestations (possible increase of side effects) is carried out symptomatic and supportive treatment. Pantoprazole is not excreted by hemodialysis.

Storage conditions

At a temperature not exceeding 25 ° C.

Expiration

3 years.

Deystvuyuschee substances

Pantoprazole

Terms of the pharmacy leave

Prescription

dosage form

dosage form

tablets

Takeda GmbH, Japan



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