tobramycin (tobramycin)

Latin name

TOBREX

Release form

Tobrex. Eye drops.

Packaging

In a dropper bottle plastic Drop Tainer 5 ml drops. In the package 1 dropper bottle with a dispenser.

Pharmacological action of

Tobrex eye drops include tobramycin, a broad-spectrum antibiotic from the aminoglycoside group. The bactericidal effect of the drug extends to bacteria streptococci and staphylococci, Klebsiella, E. coli, diphtheria bacteria.

It acts bacteriostatically at low concentrations (it blocks the 30S subunit of ribosomes and disrupts protein synthesis), and at higher concentrations it is bactericidal (disrupts the function of cytoplasmic membranes, causing the death of a microbial cell).

Highly active against Staphylococcus spp. (including Staphylococcus aureus, Staphylococcus epidermidis / coagulase-negative and coagulase-positive /, as well as strains, penicillin resistant) Streptococcus spp. (including - hemolytic species, some non-hemolytic species, Streptococcus pneumoniae) Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis (indole-negative) and indole-positive species Proteus spp., Haemophilus influen , Haemophilus aegyptius, Moraxella lacunata, Acinetobacter calcoaceticus (Herellea vaginacola), some species of Neisseria spp. (including Neisseria gonorrhoeae).

Pharmacokinetics

When applied topically, systemic absorption is low.

Indications

Infections of the eye and its appendages: - blepharitis

- conjunctivitis

- keratoconjunctivitis

- blepharoconjunctivitis

- keratitis

- iridocyclitis.

Prevention of postoperative infections.

Contraindications

Hypersensitivity to the components of the drug.

Use during pregnancy and lactation

There is no sufficient experience with the use of the drug during pregnancy and lactation (breastfeeding). It is possible to use Tobrex eye drops in pregnant women and nursing mothers if when the expected therapeutic effect exceeds the potential risk of side effects.

Use in children

There is no sufficient experience with the use of Tobrex eye drops in children. It is possible to use the drug in children if the expected therapeutic effect exceeds the potential risk of side effects.

Composition

Active ingredient:

tobramycin 3.00 mg

Excipients:

benzalkonium chloride, solution equivalent to benzalkonium chloride 0.10 mg

boric acid 12.40 mg

sodium sulfate anhydrous 1.52 mg

sodium sulfate anhydrous 1.52 mg 1.52 mg 78 mg

tyloxapol 1.00 mg

sulfuric acid and / or sodium hydroxide to adjust pH

purified water to 1 ml.

Dosage and Administration

Topically.

Eye Drops: In a mild infection process, 1-2 drops in the conjunctival sac every 4 hours.

In an acute severe infectious process, 2 drops in the conjunctival sac every 60 minutes, with a decrease in the frequency of instillations of the drug as inflammation decreases.

Side effects

Local. Allergic reaction, accompanied by itching and swelling of the eyelids, conjunctival hyperemia, lacrimation. There may be a burning sensation and sensation of a foreign body in the eye.

Drug Interaction

In the case of co-administration of tobramycin topically with systemic aminoglycoside antibiotics, systemic side effects may be exacerbated.

Overdose

Symptoms: punctate keratitis, erythema, increased lachrymation, itching and swelling of the eyelid.

Treatment is symptomatic.

Storage conditions

Store at a temperature of 8 ° to 30 ° C, out of the reach of children.

The Expiration of

is 3 years. After opening the vial, the drug should be used within 1 month.

Dosage form

Dosage form

eye drops

Alcon, USA



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