Tsellex 0.1 ml solution 1 ml ampoules 5 pcs. (Polypeptyd IZ brain embryonov pigs)

Release form

Subcutaneous solution

Pharmacological action

Nootropic drugs, other drugs that affect the nervous system.

Pharmacodynamics:

The presence of tissue-specific signaling proteins and polypeptides - growth factors, factors of differentiation of nerve cells neuroreparative effect, due to regulation of concentrations of the neurotransmitter pool, with inhibition of the spilover of exciting amino acids. The drug activates secondary neuroprotection due to the stimulation of synaptogenesis, restoration of autophagy signals, improvement of tissue immunoregulation with inhibition of macrophage immunogenic cytotoxicity. At the same time, tissue-specific and systemic reparative action of the drug is noted with the restoration of the regenerative and reparative potential of brain cells, a decrease in the number of damaged cells and the severity of perifocal edema in the penumbra zone (this can significantly limit the focus of brain tissue necrosis) with restoration of microcirculation and general perfusion. Recovery and regulatory stimulation of various CNS compartments with a systemic effect of growth factors, differentiation, and signal molecules provides a reduction in the recovery and rehabilitation time for patients with damage to the central and peripheral nervous system of the vascular genesis and restoration of motor, sensory and cognitive functions. The therapeutic effect usually develops 3-5 days after the start of the drug.

Pharmacokinetics: The complex composition of Cellex®, the active fraction of which consists of a balanced and stable mixture of biologically active proteins and polypeptides with a total multifunctional effect, does not allow for the usual pharmacokinetic analysis of individual components.

Indications

Cerebrovascular disease

- acute cerebrovascular accident in the acute and early rehabilitation

period of the course of the disease as part of complex therapy.

Use during pregnancy and lactation

The lack of appropriate studies does not allow the use of the drug in this group of patients.

Special instructions

It is prescribed with extreme caution in case of arterial hypertension of the malignant course in the stage of decompensation of sympatho-adrenal crises according to the type of panic attacks expressed by anxiety-depressive disorders. During pregnancy, the effect of the drug has not been studied. The drug does not contain prion infections and viruses.

Composition

Composition per 1 ml: Active ingredient: celllex substance-solution (frozen in terms of protein * 0.100 mg

Excipient: Glycine - 3.75 mg

Sodium hydrogen phosphate dihydrate - 2, 99 mg

Sodium dihydrogen phosphate monohydrate - 0.47 mg

Sodium chloride - 5.85 mg

Water for injection up to 1.0 ml

* - Composition per 1 ml: Active substance: Polyp peptides from the brain of pig embryos, in terms of total protein 0.9 - 2.4 mg (nominal total protein content 1.65 mg per 1 ml of substance)

Glycine 3.75 mg, 0, 1M disodium hydrogen phosphate solution to pH 7.8 (about 0.8 mg of dry

substance), Sodium chloride 5.85 mg, Polysorbate-80 0.005 mg, Purified water to 1 ml.

Dosage and administration

For adults, the drug is prescribed at a dose of 0.1 - 0.2 mg once a day subcutaneously for 10 days, depending on the severity of the patient's condition. If necessary, repeat the course after 10 days. Studies on the use of the drug in pediatric practice have not been conducted.

Rules for the introduction of the solution: The drug is administered subcutaneously through the sterile syringe filter included in the kit. For administration, the required amount of Celllex® is drawn into the syringe, the needle is removed, then a sterile syringe filter with a pore diameter of 0.22 ?m is put on the syringe. Take a new needle and put it on a sterile syringe filter. The drug is ready for use.

Side effects

Allergic reactions may occur in the form of unexpressed hyperemia at the injection site, hypersensitivity reactions (skin rash, itching, angioedema), low-grade fever, sleep disturbance, headache.

Drug Interactions

When used together with psychostimulant drugs and alcohol, psychomotor agitation and sleep disturbances are possible. Perhaps a decrease in the activity of drugs for anesthesia, tranquilizers, antipsychotics.

Overdose

There are currently no cases of overdose of the drug Celllex®.

Storage Conditions

In a dark place at 2 ° C to 8 ° C. Keep out of reach of children.

Expiration

2 years. Do not use after the expiry date stated on the packaging.

Prescription conditions from

pharmacies Prescription

Appointment

Vzrosl m on purpose doctor

Indications

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indications From cerebrovascular accidents

Possible product names

Celllex hypodermic solution 0.1 mg / ml 1 ml ampoules 5 pcs.



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