Urorek capsules 8 mg, 30 pcs. (Sylodozyn)

Release form

Urorek. Capsules

Packing

In a package of 30 pieces.

Pharmacological action

Urorek - highly selective competitive antagonist of alpha 1a-adrenergic receptors, blocks postsynaptic alpha 1a-adrenergic receptors, located in the smooth muscles of the prostate gland, the neck of the bladder and the prostatic part of the urethra. Reduces the tone of the smooth muscles of the prostate gland, bladder neck and prostatic urethra, improving urine outflow. At the same time, the symptoms of obstruction and irritation associated with benign prostatic hyperplasia are reduced. Affinity for alpha | 1a-adrenergic receptors located in the bladder are 162 times greater than its ability to interact with alpha-1b-adrenergic receptors, which are located in the smooth muscles of blood vessels. Due to its high selectivity, it does not cause a clinically significant decrease in blood pressure (BP) in patients with initially normal blood pressure.

Indications

Benign prostatic hyperplasia.

Contraindications

Hypersensitivity to the active substance or any of the auxiliary

components or their intolerance

Children under 18 years of age

Severe renal failure (creatinine clearance less than 30 ml / min)

Severe: poor liver: poor and moderate renal failure (creatinine clearance from 30 to 50 ml / min).

Pregnancy and lactation

Silodozin is intended for men only.

Composition

1 capsule contains: 8 mg silodosin.

Excipients: mannitol, pregelatinized starch (1500 ™ starch), pregelatinized starch (PCS ™ PC-10 starch), sodium lauryl sulfate, magnesium stearate.

Composition of gelatin capsule: gelatin, titanium dioxide, iron oxide yellow oxide (E-172)

Dosage and administration

Recommended dose - 8 mg 1 time / day, with meals, preferably at the same time of day. It is necessary to swallow the whole capsule, preferably with a glass of water.

In the treatment of patients with moderate renal failure (CC from 30 to 50 ml / min)

It is recommended to take the drug at a dose of 4 mg / day during the first week, with good individual tolerance, then the dose can be increased to 8 mg / day.

In severe renal failure

Prescribing silodosin is not recommended.

Side effects

From the central nervous system: often - dizziness frequency unknown - syncope.

From the cardiovascular system: often - orthostatic hypotension.

From the respiratory system: often - nasal congestion.

From the digestive system: often - diarrhea infrequently - nausea, dry mouth.

From the reproductive system: very often - retrograde ejaculation, anejaculation infrequently - decreased libido, erectile dysfunction.

Other: frequency unknown - intraoperative flabby iris syndrome during cataract surgery.

Drug Interaction

Combination with other alpha blockers is not recommended due to its potential potentiation. Co-administration of CYP3A4 isoenzyme inhibitors (ketoconazole, clarithromycin, itraconazole, ritonavir) is not recommended because increases the concentration of silodosin in plasma. PDE5 inhibitors (sildenafil, tadalafil) when used together may increase the risk of dizziness. Hypotensive drugs (beta-blockers, calcium antagonists, RAAS drugs, diuretics) when used jointly increase orthostatic hypotension.

Overdose

Symptoms: marked decrease in blood pressure, compensatory tachycardia.

Treatment: gastric lavage, activated charcoal or osmotic laxative, symptomatic therapy, aimed at increasing BCCs, vasoconstrictive drugs. Control of kidney function. Dialysis is ineffective due to the intense binding of the drug to plasma proteins.

Storage conditions

The drug should be stored in a dry, dark place, out of the reach of children, at a temperature not exceeding 30 ° C.

Expiration

2 years.

Deystvuyuschee substances

Sylodozyn

Pharmacy terms

Prescription

dosage form

dosage form

capsules



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