Vaccine SOVIGRIPP influenza inactive.subedinich., Amp 0.5ml (1 dose) No. 10 (Vaccine for Prevention hryppa ynaktyvyrovannaya)

Pharmacological action of

The vaccine is a surface glycoprotein (hemagglutinin and neuraminidase) isolated from purified type A and B influenza virions, obtained from virus-containing allantoic fluid of chicken embryos from clinically healthy chickens, and diluted in phosphate-buffered saline, in combination with adjuvant SOVIDON. The drug is available with a preservative - thiomersal (thiolate), or without a preservative.

The antigenic composition of the strains changes annually in accordance with the recommendations of the WHO and the Commission on influenza vaccine and diagnostic strains of the Ministry of Health of Russia.

Contraindications

1. Allergic reactions to chicken protein or other components of the vaccine.

2. Strong post-vaccination reactions (temperature above 40 ° C, the appearance of edema at the injection site, hyperemia over 8 cm in diameter) or post-vaccination complications (collapse, non-febrile seizures, anaphylaxis) to the previous administration of the influenza vaccine.

3. Pregnancy (when using a vaccine with a preservative)

4. Age up to 18 years (when using a vaccine with a preservative)

5. Age up to 6 months.

Temporary contraindications: 1. Acute febrile illness, acute infectious and non-infectious diseases, including the period of convalescence. Vaccination is usually carried out 2-4 weeks after recovery.

2. Chronic diseases in the acute stage, vaccination is carried out during the period of remission. The possibility of vaccinating individuals suffering from chronic diseases, determines the attending physician, based on the condition of the patient.

3. In mild forms of acute respiratory viral and intestinal infections, vaccination is carried out after normalization of the temperature and / or disappearance of the acute symptoms of the disease

Special instructions

Do not administer intravenously!

On the day of vaccination, vaccinees should be examined by a general practitioner / feldsher with mandatory thermometry. At temperatures above 37 ° C, vaccination is not carried out.

Vaccination sites should be equipped with anti-shock therapy. The vaccinated should be under medical supervision for 30 minutes after administration of the drug.

Composition

1 dose (0.5 ml) contains: Vaccine with preservative: - subtype A influenza virus hemagglutin (H1N1) - 5mkg

influenza hemagglutin subtype A (H3N2) influenza virus - 5mkg srdlgm virus type - -

- adjuvant SOVIDON - 500 Ојg

- preservative thiomersal (thiolate) - (50.0 В± 7.5) Ојg

- phosphate buffered saline - up to 0.5 ml.

Vaccine without preservative: - hemagglutin of influenza virus subtype A (H1N1) - 5 Ојg

- hemagglutin of influenza virus subtype A (H3N2) - 5 Ојg

- type B influenza hemagglutin - 11 Ојg srdlcpfg buffer solution - up to 0.5 ml.

Composition of phosphate-saline buffer solution No. 1 (for the preparation without preservative): 9 g of sodium chloride, 1.5 g of sodium hydrogen phosphate, 0.12-0.14 g of potassium dihydrogen phosphate, water for injection up to 1l.

Composition of phosphate-saline buffer solution No. 2 (for the preparation with preservative): 9 g of sodium chloride, 1.5 g of sodium hydrogen phosphate, 0.12-0.14 g of potassium dihydrogen phosphate, 0.85 ml of thiomersal (merthiolate) solution 1%, water for injection up to 1 liter

Dosage and administration

Vaccination is carried out annually in the autumn-winter period. Vaccination is possible at the beginning of the epidemic rise in the incidence of influenza.

For children over 3 years of age, adolescents and adults without age restrictions, the vaccine is administered intramuscularly once into the upper third of the external surface of the shoulder (to the deltoid muscle) in a vaccination dose of 0.5 ml.

For children from 6 months to 3 years of age, the vaccine is administered twice with an interval of 4 weeks into the anteroposterior thigh intramuscularly in a vaccination dose of 0.25 ml (1/2 dose) according to the following administration schemes:

1. From an ampoule containing 0.5 ml ( 1 dose) of the drug, 0.25 ml of the vaccine is selected with a sterile syringe having an appropriate graduation. The remainder of the vaccine in the vial should be disposed of immediately.

2. When using a syringe containing 0.5 ml of the drug, you must remove half of the contents by pressing on the syringe plunger, up to the corresponding risks on the syringe. The patient is given the remaining amount of the vaccine (0.25 ml).

Opening of ampoules and the vaccination procedure is carried out with strict observance of the rules of asepsis and antiseptics.

The drug should not be stored in opened ampoules / syringes.

is NOT SUITABLE for use in ampoules / syringes with altered physical properties (color, transparency), broken integrity and labeling, expired Expiration, storage and / or transportation conditions

Side effects

The vaccine is a highly purified drug and is well tolerated by the vaccinee.

The following reactions are possible:

Very often (> 1/10): - local reactions: soreness on palpation, tightening, swelling and hyperemia of the skin at the injection site

- systemic reactions: low-grade fever, malaise, headache. sore and sore throat, mild runny nose.

The indicated local and systemic reactions are transient in nature and disappear after 1-2 days without the appointment of specific therapy.

Very rarely (<1/10 000): - with high individual sensitivity, allergic reactions can be observed: anaphylactic shock, angioedema, urticaria, rash (erythematous, papular), etc.

Dispensing conditions from

pharmacies Prescription

dosage form

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