Vasonite tablets retard 600 mg, 20 pcs. (pentoksifillina)
Special Price
$24.65
Regular Price
$29.00
In stock
SKU
newyork462175
Latin name
Vasonit Buy Vasonite tablets retard 600 mg, 20 pcs. (pentoksifillina) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Vasonit Buy Vasonite tablets retard 600 mg, 20 pcs. (pentoksifillina) in newyork free shipping. Fast international shipping USA, AU, EU, UK and others.
Latin name
Vasonit
packaging 20 pcs
Pharmacological action
Wazonite - angioprotective, antiplatelet, vasodilator.
Improves microcirculation and rheological properties of blood. It inhibits phosphodiesterase, contributing to the accumulation of cAMP in tissues and organs, including in the cells of the smooth muscles of blood vessels, in the formed elements of the blood.
It inhibits platelet and erythrocyte aggregation, increases the elasticity of their membranes, lowers plasma fibrinogen concentration and enhances fibrinolysis. Improves the supply of tissue with oxygen, most in the limbs, central nervous system and, to a lesser extent, in the kidneys. Slightly dilates the coronary vessels.
Pharmacokinetics
When ingestible tablets are administered, the active substance is continuously released and absorbed uniformly from the digestive tract. It undergoes metabolism in the liver during the "first passage", as a result of which a number of pharmacologically active metabolites are formed.
Cmax of pentoxifylline and its active metabolites in plasma is reached after 3-4 hours and remains at the therapeutic level for 12 hours. It is excreted mainly with urine in the form of metabolites.
Indications
Peripheral circulatory disorders (intermittent claudication against the background of diabetic angiopathy, obliterating endarteritis), Raynaud’s disease, tissue trophic disorders (postthrombotic syndrome, varicose veins, trophic ulcers of the leg, gangrene, otorrhagia, and otorrhagia)
cerebral atherosclerosis (dizziness, memory impairment, sleep disturbance), discirculatory encephalopathy, viral neuroinfection (prevention of possible microcirculatory disturbance)
ischemic heart disease, condition after myocardial infarction
acute circulatory disorders in the retina and choroid of the eye otosclerosis, degenerative changes in the background of vascular pathology of the inner ear with a gradual hearing loss
Asthma pulmonary artery disease, bronchial vascular disease.
Contraindications
Hypersensitivity to pentoxifylline and other xanthine derivatives
acute myocardial infarction
porphyria, massive bleeding, hemorrhagic stroke, retinal hemorrhage, pregnancy, lactation.
Caution: blood pressure lability (tendency to hypotension), heart failure, gastric and duodenal ulcer (for oral administration), condition after recent surgery, liver and / or renal failure, under 18 years of age (efficacy and safety not studied).
Use during pregnancy and lactation
Use of the drug Vasonite during pregnancy is contraindicated.
If you need to use the drug during lactation, you should stop breastfeeding.
Composition of
1 tablet contains:
Active ingredient:
pentoxifylline 600 mg
Excipients:
hypromellose 15000 mPa * s,
microcrystalline cellulose, srdl silicon microspide
hypromellose 5 mPa * s,
antifoaming agent SE2 MK silicon,
titanium dioxide,
talc,
polyacrylate dispersion 30%.
Dosage and administration
Enteric-coated tablets are swallowed whole with a little water.
The daily dose is divided into 3 doses. The initial dose is 600 mg / day.
As the condition improves, the dose can be reduced to 300 mg / day. Prolonged dosage forms are prescribed 2-3 times a day.
Side effects of the
From the digestive system: possibly nausea, vomiting, diarrhea, dry mouth, decreased appetite, sensation of fullness in the abdomen, epigastric pain, increased activity of liver enzymes (ALT, AST, LDH) and alkaline phosphatase, cholecystitis, hepatitis, jaundice rarely - an unpleasant taste in the mouth, hypersalivation.
From the side of the central nervous system: relatively rarely - headache, dizziness, anxiety, sleep disturbances, cramps.
On the part of the sensory organs: rarely - conjunctivitis, scotoma, blurred visual perception, earache.
From the cardiovascular system: when using the drug in high doses, a decrease in blood pressure, tachycardia, angina pectoris, heart rhythm disturbances, hyperemia of the skin of the face, flushing of the skin of the face and upper chest, swelling.
Allergic reactions: possibly - itching, skin rash, urticaria, Quincke's edema rarely - anaphylactic shock.
From the hemopoietic system and hemostasis: rarely - bleeding (from the vessels of the stomach, intestines, skin and mucous membranes), thrombocytopenia, leukopenia, pancytopenia, hypofibrinogenemia, changes in the pattern of peripheral blood, aplastic anemia. In this regard, it is necessary to conduct regular monitoring of the blood picture.
Other: rarely - malaise, increased brittle nails, changes in body weight, nasal congestion.
Drug Interaction
Pentoxifylline may enhance the action of drugs that affect the blood coagulation system (indirect and direct anticoagulants, thrombolytics), anitibiotics (including cephalosporins - cefamandol, cefapetazole, cefapetazole, cefatrazole).
Increases the effectiveness of hypotensive drugs, insulin and oral hypoglycemic drugs.
Cimetidine increases the concentration of pentoxifylline in plasma (risk of side effects).
Joint appointment with dr. xanthines can lead to excessive nervous excitation of patients.
Overdose
Symptoms: nausea, dizziness, decrease in blood pressure, fever, tachycardia, drowsiness or agitation, loss of consciousness, areflexia, tonic-clonic convulsions, vomiting, like arrhythmias.
Treatment: gastric lavage, then carry out symptomatic therapy. There is no specific antidote. In case of vomiting with traces of blood, gastric lavage is not allowed.
Storage conditions
The drug should be stored in a dry, dark place, out of the reach of children, at a temperature not exceeding 25 ° C.
Expiration
5 years
Active ingredient
Pentoxifylline
Dosage form
Dosage form
tablets prolong.
G.L. Farma GmbH, Austria
Vasonite tablets retard 600 mg, 20 pcs. (pentoksifillina) newyork in pharmacy online. Cheap price, instruction, side effects, dosage. Vasonite tablets retard 600 mg, 20 pcs. - Sale. PayPal accept. Free shipping newyork. Fast international shipping.
Vasonit
packaging 20 pcs
Pharmacological action
Wazonite - angioprotective, antiplatelet, vasodilator.
Improves microcirculation and rheological properties of blood. It inhibits phosphodiesterase, contributing to the accumulation of cAMP in tissues and organs, including in the cells of the smooth muscles of blood vessels, in the formed elements of the blood.
It inhibits platelet and erythrocyte aggregation, increases the elasticity of their membranes, lowers plasma fibrinogen concentration and enhances fibrinolysis. Improves the supply of tissue with oxygen, most in the limbs, central nervous system and, to a lesser extent, in the kidneys. Slightly dilates the coronary vessels.
Pharmacokinetics
When ingestible tablets are administered, the active substance is continuously released and absorbed uniformly from the digestive tract. It undergoes metabolism in the liver during the "first passage", as a result of which a number of pharmacologically active metabolites are formed.
Cmax of pentoxifylline and its active metabolites in plasma is reached after 3-4 hours and remains at the therapeutic level for 12 hours. It is excreted mainly with urine in the form of metabolites.
Indications
Peripheral circulatory disorders (intermittent claudication against the background of diabetic angiopathy, obliterating endarteritis), Raynaud’s disease, tissue trophic disorders (postthrombotic syndrome, varicose veins, trophic ulcers of the leg, gangrene, otorrhagia, and otorrhagia)
cerebral atherosclerosis (dizziness, memory impairment, sleep disturbance), discirculatory encephalopathy, viral neuroinfection (prevention of possible microcirculatory disturbance)
ischemic heart disease, condition after myocardial infarction
acute circulatory disorders in the retina and choroid of the eye otosclerosis, degenerative changes in the background of vascular pathology of the inner ear with a gradual hearing loss
Asthma pulmonary artery disease, bronchial vascular disease.
Contraindications
Hypersensitivity to pentoxifylline and other xanthine derivatives
acute myocardial infarction
porphyria, massive bleeding, hemorrhagic stroke, retinal hemorrhage, pregnancy, lactation.
Caution: blood pressure lability (tendency to hypotension), heart failure, gastric and duodenal ulcer (for oral administration), condition after recent surgery, liver and / or renal failure, under 18 years of age (efficacy and safety not studied).
Use during pregnancy and lactation
Use of the drug Vasonite during pregnancy is contraindicated.
If you need to use the drug during lactation, you should stop breastfeeding.
Composition of
1 tablet contains:
Active ingredient:
pentoxifylline 600 mg
Excipients:
hypromellose 15000 mPa * s,
microcrystalline cellulose, srdl silicon microspide
hypromellose 5 mPa * s,
antifoaming agent SE2 MK silicon,
titanium dioxide,
talc,
polyacrylate dispersion 30%.
Dosage and administration
Enteric-coated tablets are swallowed whole with a little water.
The daily dose is divided into 3 doses. The initial dose is 600 mg / day.
As the condition improves, the dose can be reduced to 300 mg / day. Prolonged dosage forms are prescribed 2-3 times a day.
Side effects of the
From the digestive system: possibly nausea, vomiting, diarrhea, dry mouth, decreased appetite, sensation of fullness in the abdomen, epigastric pain, increased activity of liver enzymes (ALT, AST, LDH) and alkaline phosphatase, cholecystitis, hepatitis, jaundice rarely - an unpleasant taste in the mouth, hypersalivation.
From the side of the central nervous system: relatively rarely - headache, dizziness, anxiety, sleep disturbances, cramps.
On the part of the sensory organs: rarely - conjunctivitis, scotoma, blurred visual perception, earache.
From the cardiovascular system: when using the drug in high doses, a decrease in blood pressure, tachycardia, angina pectoris, heart rhythm disturbances, hyperemia of the skin of the face, flushing of the skin of the face and upper chest, swelling.
Allergic reactions: possibly - itching, skin rash, urticaria, Quincke's edema rarely - anaphylactic shock.
From the hemopoietic system and hemostasis: rarely - bleeding (from the vessels of the stomach, intestines, skin and mucous membranes), thrombocytopenia, leukopenia, pancytopenia, hypofibrinogenemia, changes in the pattern of peripheral blood, aplastic anemia. In this regard, it is necessary to conduct regular monitoring of the blood picture.
Other: rarely - malaise, increased brittle nails, changes in body weight, nasal congestion.
Drug Interaction
Pentoxifylline may enhance the action of drugs that affect the blood coagulation system (indirect and direct anticoagulants, thrombolytics), anitibiotics (including cephalosporins - cefamandol, cefapetazole, cefapetazole, cefatrazole).
Increases the effectiveness of hypotensive drugs, insulin and oral hypoglycemic drugs.
Cimetidine increases the concentration of pentoxifylline in plasma (risk of side effects).
Joint appointment with dr. xanthines can lead to excessive nervous excitation of patients.
Overdose
Symptoms: nausea, dizziness, decrease in blood pressure, fever, tachycardia, drowsiness or agitation, loss of consciousness, areflexia, tonic-clonic convulsions, vomiting, like arrhythmias.
Treatment: gastric lavage, then carry out symptomatic therapy. There is no specific antidote. In case of vomiting with traces of blood, gastric lavage is not allowed.
Storage conditions
The drug should be stored in a dry, dark place, out of the reach of children, at a temperature not exceeding 25 ° C.
Expiration
5 years
Active ingredient
Pentoxifylline
Dosage form
Dosage form
tablets prolong.
G.L. Farma GmbH, Austria
Vasonite tablets retard 600 mg, 20 pcs. (pentoksifillina) newyork in pharmacy online. Cheap price, instruction, side effects, dosage. Vasonite tablets retard 600 mg, 20 pcs. - Sale. PayPal accept. Free shipping newyork. Fast international shipping.
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