Verapamil tablets retard 240 mg, 20 pcs. (Verapamil)

Release form

Tablets.

Packing

20 pcs.

Pharmacological action

Verapamil is a selective calcium channel blocker of class I. The main pharmacological properties of the drug are due to its ability to prevent the entry of calcium ions into cardiomyocytes and smooth muscle cells of the vascular wall through the slow calcium channels of the membrane. Verapamil has antiarrhythmic, antianginal and antihypertensive activity. Reduces myocardial oxygen demand by reducing myocardial contractility and lowering heart rate. It causes the expansion of the coronary arteries and an increase in coronary blood flow. The antihypertensive effect of Verapamil is associated with a decrease in the tone of the smooth muscles of peripheral arteries and with the ability to reduce OPSS. Slowing AV conduction, Verapamil has an antiarrhythmic effect in supraventricular arrhythmias, normal heart rate remains unchanged or decreases slightly.

Verapamil also has some natriuretic and diuretic effects by reducing tubular reabsorption.

Indications

prevention of angina attacks (including Prinzmetal angina)

treatment and prevention of supraventricular arrhythmias (paroxysmal supraventricular tachycardia, atrial fibrillation, atrial flutter, hypertension).

Contraindications

ardiogenic shock

severe bradycardia

sinus node syndrome syndrome

AV block II-III degree

Wolff-Parkinson-White syndrome

arterial hypotension cardiac hypertension

acute chronical hypertension



Special instructions

With caution, the drug is prescribed for patients with impaired liver function, with acute myocardial infarction. The use of verapamil during pregnancy is only possible if the intended benefit to the mother outweighs the potential risk to the fetus. When using the drug during lactation, the issue of stopping breastfeeding should be decided.

With caution, prescribe Verapamil to patients involved in potentially hazardous activities requiring increased attention and speed of motor and mental reactions.

Composition

1 tablet contains 240 mg of verapamil.

Dosing and Administration

Dosing regimen Verapamil hydrochloride is set individually. Adults are prescribed in an initial dose of 40-80 mg 3 times a day. The maximum daily dose is 480 mg. Children aged 6-14 years are prescribed 80-360 mg per day, children under 6 years of age - 40-60 mg per day, the frequency of use 3-4 times a day. Tablets are taken with meals or immediately after meals with a little water.

Side effects of the

From the cardiovascular system: bradycardia (less than 50 beats / min), marked decrease in blood pressure, development or worsening of heart failure, tachycardia rarely - angina pectoris, up to the development of myocardial infarction (especially in patients with severe obstructive damage coronary arteries), arrhythmia (including ventricular fibrillation and flutter) with rapid on / on - AV block III degree, asystole, collapse.

From the side of the central nervous system and peripheral nervous system: dizziness, headache, fainting, anxiety, lethargy, fatigue, asthenia, drowsiness, depression, extrapyramidal disorders (ataxia, masky face, shuffling gait, stiffness of the hands or feet, trembling of the hands and fingers difficulty swallowing).

From the digestive system: nausea, constipation (rarely diarrhea), gum hyperplasia (bleeding, soreness, swelling), increased appetite, increased activity of hepatic transaminases and alkaline phosphatase.

Allergic reactions: itching, skin rash, facial flushing, erythema multiforme exudative (including Stevens-Johnson syndrome).

Other: weight gain, very rarely - agranulocytosis, gynecomastia, hyperprolactinemia, galactorrhea, arthritis, transient vision loss with Cmax, pulmonary edema, asymptomatic thrombocytopenia, peripheral edema.

Drug interaction

Concurrent use of verapamil and beta-blockers, antiarrhythmic drugs, funds for inhalation anesthesia can lead to a mutual strengthening of their cardiodepressive effects (AV block, bradycardia, hypotension, heart failure). With simultaneous use with quinidine in patients with hypertrophic obstructive cardiomyopathy, severe hypotension and pulmonary edema may develop.

With the simultaneous administration of Verapamil with other antihypertensive drugs, mutual potentiation of their effects is noted. Verapamil is able to significantly increase the concentration of digoxin in plasma, which requires a reduction in the dose of cardiac glycoside when used together. The neurotoxic effect of Verapamil is potentiated by carbamazepine and lithium salts, and the psychotropic effect of lithium when co-administered with verapamil is weakened. The concentration of cyclosporine or theophylline in blood plasma increases when used together with verapamil. Rifampicin, phenytoin, phenobarbital and cimetidine are able to reduce the concentration of verapamil in plasma and reduce the effectiveness of the latter. Verapamil potentiates the effect of muscle relaxants.

Storage Conditions

Do not store above 25 ° C.

The Expiration of

is 3 years.

Conditions of dispatch from

61 pharmacy TMP

Dosage form

tablet prolong.

Alkaloid AD Skopye, Macedonia



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