Viagra tablets 100 mg, 2 pcs. (sildenafil)

Release form

Coated tablets.

Packaging

In the package 2 pcs.

Pharmacological action

VIAGRA - a drug for the treatment of erectile dysfunction - erectile dysfunction. Acts on the natural mechanisms of erection. It is used in men suffering from erectile dysfunction of various origins (vascular, nervous erection disorders).

Sildenafil is a potent and selective inhibitor of cGMP-specific type 5 phosphodiesterase (PDE5).

The physiological mechanism of penile erection involves the release of nitric oxide (NO) in the cavernous body during sexual stimulation.

Nitric oxide activates the enzyme guanylate cyclase, which leads to an increase in the level of cyclic guanosine monophosphate (cGMP), relaxation of the smooth muscles of the cavernous body and increased blood flow in the penis.

Sildenafil does not have a direct relaxing effect on an isolated human cavernous body, but actively enhances the relaxing NO effect on this tissue by inhibiting PDE5, which is responsible for the breakdown of cGMP in the cavernous body.

During sexual arousal, local release of NO under the influence of sildenafil leads to inhibition of PDE5 and an increase in cGMP in the cavernous body, resulting in relaxation of smooth muscles and increased blood flow in the cavernous body.

A prerequisite for the effectiveness of sildenafil is sexual stimulation.

Indications

Treatment of erectile dysfunction characterized by an inability to achieve or maintain an erection of the penis sufficient for satisfactory intercourse.

Viagra is effective only if there is sexual stimulation.

Contraindications

- Hypersensitivity to any component of the drug.

- Use in patients receiving nitric oxide donors continuously or intermittently, organic nitrates or nitrites in any form.

- Age to 18 years.

- Not intended for use in women.

Precautions: anatomical deformation of the penis (including angulation, cavernous fibrosis, or Peyronn disease), diseases predisposing to the development of priapism (such as sickle cell anemia, multiple myeloma, leukemia, thrombocythemia), diseases accompanied by bleeding, bleeding, bleeding peptic ulcer disease, hereditary retinitis pigmentosa, heart failure, unstable angina pectoris, myocardial infarction, stroke or life-threatening arrhythmias, arterial hypertension, past 6 months Zia (BP> 170/100 mm Hg. Art.) or hypotension (blood pressure <90/50 mm Hg. Art.).

Pregnancy and lactation

Not intended for use in women.

Composition

Active substance: sildenafil (as sildenafil citrate) 100 mg

excipients: microcrystalline cellulose, calcium hydrogen phosphate (anhydrous), croscarmellose sodium, magnesium stearate,

film coating Opadry blue and Opadry transparent.

Dosage and administration

The drug is taken orally.

For most patients, the recommended dose is 50 mg, if necessary, take about 1 hour before sexual activity. Given the effectiveness and tolerability, the dose can be increased to 100 mg or reduced to 25 mg.

Maximum recommended dose is 100 mg.

The maximum recommended frequency of use is 1 time / day.

Side effects

Adverse events are usually transient and mild or moderate. The frequency of adverse events increases with increasing dose.

On the part of the body as a whole: asthenia, pain, abdominal pain, back pain, infection, flu-like syndrome.

From the cardiovascular system: vasodilation (a side effect recorded in clinical trials).

From the digestive system: diarrhea, nausea.

From the musculoskeletal system: joint pain, muscle pain.

From the side of the central nervous system and peripheral nervous system: dizziness (side effect, registered in clinical studies), increased muscle tone, insomnia.

From the respiratory system: nasal congestion, pharyngitis, rhinitis (a side effect recorded in clinical trials), sinusitis, respiratory tract infections, respiratory failure.

Dermatological reactions: rash.

On the part of the sensory organs: change in vision: slight and transient, mainly a change in the color of objects, as well as increased perception of light and blurred vision (a side effect recorded in clinical studies), conjunctivitis.

From the urinary system: urinary tract infections.

From the reproductive system: impaired prostate function.

When using the drug in doses exceeding the recommended ones, side effects were similar to those noted above, but were usually more common.

The following are adverse events that have been reported during post-marketing applications.

From the cardiovascular system: arterial hypotension, fainting, tachycardia, palpitations.

From the digestive system: vomiting (a side effect reported in clinical studies).

From the reproductive system: prolonged erection and / or priapism.

From the sensory organs: pain in the eyes, redness of the eyes.

Other: allergic reactions.

Storage conditions

Store in a dry, out of reach of children at a temperature not exceeding 30 ° C.

Expiration

5 years.

active substance

Sildenafil

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