Xizal tablets 5 mg, 10 pcs. (Levocetirizine)

Release form

film-coated tablets.

Packing

10 pcs.

Pharmacological action

Xizal is an antiallergic drug. The active substance of the drug is levocetirizine, the enantiomer of cetirizine, belongs to the group of competitive histamine antagonists. Levocetirizine affects the histamine-dependent stage of allergic reactions, and also reduces the migration of eosinophils, reduces vascular permeability, and limits the release of inflammatory mediators. It prevents the development and facilitates the course of allergic reactions, has an antiexudative, antipruritic effect, practically has no anticholinergic and antiserotonin effect. In therapeutic doses, it has almost no sedative effect.

Indications

For adults and children over 6 years of age: treatment of symptoms of perennial and seasonal allergic rhinitis and allergic conjunctivitis, such as pruritus, sneezing, lacrimation, hyperemia of the hay fever conjunctiva (hay fever) of urticaria, including chronic idiopathic urticaria, Quincke edema, other allergic dermatoses, and accompanying.

Contraindications

Hypersensitivity to any component of the drug or piperazine derivatives. Severe form of chronic renal failure (creatinine clearance less than 10 ml / min). Children's age (up to 6 years).

Precautions - chronic renal failure (dosage adjustment required), advanced age (possibly reduced glomerular filtration).

Special instructions

When objectively assessing the ability to drive a car and work with mechanisms, no undesirable phenomena were reliably detected when prescribing the recommended dose of 5 mg, nevertheless, it is advisable to refrain from engaging in potentially hazardous activities that require an increased concentration of attention and speed psychomotor reactions.

Composition

1 tablet contains 5 mg levocetirizine dihydrochloride.

Dosage and administration

Applied orally with food or on an empty stomach, washed down with a small amount of water, without chewing. Adults and children over 6 years: daily dose - 5 mg (1 tablet). Elderly patients (subject to normal renal function) dose reduction is not required. For patients with chronic renal failure, the dose is halved (1 tablet every other day) with CC from 30 to 49 ml / min and 3 times (1 tablet in 3 days) with CC from 10 to 29 ml / min. Patients with hepatic insufficiency do not need to adjust the dosage regimen.

Duration of administration depends on the disease. For the treatment of hay fever, an average of 1-6 weeks is prescribed. In chronic diseases (year-round rhinitis, atonic dermatitis), the duration of treatment can increase up to 18 months.

Side effects

Headache, drowsiness, dry mouth, fatigue. Rarely - migraine, dizziness, dyspeptic disorders, allergic reactions (angioedema, rash, urticaria, pruritus).

Drug Interactions

Co-administration with macrolides or ketoconazole did not cause significant changes on the ECG. Joint administration with theophylline (400 mg / day) reduces the total clearance of levocetirizine by 16% (the kinetics of theophylline does not change). When used in therapeutic doses, data on interaction with alcohol have not been obtained. Nevertheless, it is necessary to refrain from the use of alcohol-containing drinks.

Overdose

Symptoms: may be accompanied by signs of intoxication in the form of drowsiness, in children an overdose of the drug may be accompanied by anxiety and increased irritability.

Treatment: if symptoms of an overdose appear (especially in children), the drug should be discontinued, gastric lavage, activated carbon, symptomatic therapy. There is no specific antidote.

Storage Conditions

In a dry place, at a temperature not exceeding 25 ° C.

Active ingredient

Levocetirizine

Dispensing conditions for the

pharmacies Over-the-counter

Dosage form

tablet

Indications

Krapyvnytsa, Allerhycheskyy rynyt, dermatitis, Kozhn y itching, Pollynoz, edema Kvynke , Allergic conjunctivitis, Swelling of the nasal mucosa

YUSB Pharma S.A., Belgium



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